Demetri Yannopoulos, MD

Associate Professor of Medicine
Research Director, Interventional Cardiology
Medical Director, Minnesota Resuscitation Consortium

Born in London, UK, Dr. Yannopoulos received his M.D. from the University of Athens in Greece. He completed his medicine residency and general-cardiology fellowship at the University of Minnesota. Following an interventional-cardiology fellowship at Johns Hopkins University in Baltimore, Maryland, Dr. Yannopoulos joined the University of Minnesota faculty in 2008. In March 2010, he became the research director for interventional cardiology.

Dr. Yannopoulos is board-certified in internal medicine, cardiology, and interventional cardiology. His clinical interests include emergent cardiac care, coronary-artery disease, and congenital and peripheral intervention.

Dr. Yannopoulos’s research involves cardiopulmonary resuscitation, hypothermia, and myocardial salvage during acute coronary syndromes. He is considered an authority in cardiorespiratory interactions and hypothermia during CPR. His work in the laboratories of Dr. Keith Lurie (at the University of Minnesota) and Dr. Henry Halperin (at Johns Hopkins University) has helped change current CPR practices.

Dr. Yannopoulos is a member of the American Heart Association’s CPR guidelines-writing committee, and of the basic life support and research working-group subcommittees. He also serves on the organization committee for the AHA’s Resuscitation Science Symposium (ReSS), the largest international conference addressing CPR and emergent cardiac/trauma care.

Dr. Yannopoulos is the recipient of five American Heart Association Young Investigator awards (2005, 2008, 2009, 2010, 2011), and has received AHA and NIH grant support for his work in CPR devices designed to improve bloodflow and clinical outcomes.

Professional Organizations

• American College of Cardiology, member
• American Heart Association, member
• British Medical Council, member
• Medical Association of Athens, member

Journals (Review)

Circulation
Clinical Cardiology
Critical Care Medicine
Future Medicine
Japanese Journal of Pharmacology
Pediatric Research
Resuscitation

Selected Publications

Yannopoulos D, Segal N, McKnite S, Aufderheide TP, Lurie KG. Controlled pauses at the initiation of sodium nitroprusside-enhanced cardiopulmonary resuscitation facilitate neurological and cardiac recovery after 15 mins of untreated ventricular fibrillation. Crit Care Med. 2012;40:1562-1569

Segal N, Yannopoulos D, Mahoney BD, Frascone RJ, Matsuura T, Cowles CG, McKnite SH, Chase DG. Impairment of carotid artery blood flow by supraglottic airway use in a swine model of cardiac arrest. Resuscitation. 2012

Segal N, Matsuura T, Caldwell E, Sarraf M, McKnite S, Zviman M, Aufderheide TP, Halperin HR, Lurie KG, Yannopoulos D. Ischemic postconditioning at the initiation of cardiopulmonary resuscitation facilitates functional cardiac and cerebral recovery after prolonged untreated ventricular fibrillation. Resuscitation. 2012

Segal N, Caldwell E, Yannopoulos D. Improving rosc with high dose of epinephrine. Are we really? Resuscitation. 2012;83:e71; author reply e73

Schultz JC, Yannopoulos D. Is intrathoracic pressure regulation at the threshold of new resuscitation science?*. Crit Care Med. 2012;40:1008-1009

Schultz J, Segal N, Kolbeck J, McKnite S, Caldwell E, Yannopoulos D. Sodium nitroprusside enhanced cardiopulmonary resuscitation (snpecpr) improves vital organ perfusion pressures and carotid blood flow in a porcine model of cardiac arrest. Resuscitation. 2012;83:374-377

Metzger AK, Herman M, McKnite S, Tang W, Yannopoulos D. Improved cerebral perfusion pressures and 24-hr neurological survival in a porcine model of cardiac arrest with active compression-decompression cardiopulmonary resuscitation and augmentation of negative intrathoracic pressure*. Crit Care Med. 2012;40:1851-1856

Yannopoulos D, Matsuura T, Schultz J, Rudser K, Halperin HR, Lurie KG. Sodium nitroprusside enhanced cardiopulmonary resuscitation improves survival with good neurological function in a porcine model of prolonged cardiac arrest. Crit Care Med. 2011;39:1269-1274

Yannopoulos D, Kotsifas K, Lurie KG. Advances in cardiopulmonary resuscitation. Heart Fail Clin. 2011;7:251-268, ix

Yannopoulos D, Halperin HR. During cpr, push hard and fast and please do not stop! Resuscitation. 2011;82:1475-1476

Yannopoulos D, Aufderheide TP, Frascone RJ, Wayne MA, Mahoney BD, Swor RA, Domeier RM, Olinger ML, Holcomb RG, Tupper DE. Milestones in treatment: The tipping point and the resq trial. Lancet. 2011;377:2081-2082; author reply 2082-2083

Segal N, Rees J, Convertino VA, Metzger A, Zarama D, Voulgaropoulos L, McKnite SH, Yannopoulos D, Tang W, Vicaut E, Lurie K. Improving microcirculation with therapeutic intrathoracic pressure regulation in a porcine model of hemorrhage. Resuscitation. 2011;82 Suppl 2:S16-22

Schultz JC, Segal N, Caldwell E, Kolbeck J, McKnite S, Lebedoff N, Zviman M, Aufderheide TP, Yannopoulos D. Sodium nitroprusside-enhanced cardiopulmonary resuscitation improves resuscitation rates after prolonged untreated cardiac arrest in two porcine models. Crit Care Med. 2011;39:2705-2710

Schultz J, Yannopoulos D. A new standard dual-device method for cpr: The evolution of a new model of physiological synergy to improve patient care. Future Cardiol. 2011;7:451-454

Schultz J, Segal N, Kolbeck J, Caldwell E, Thorsgard M, McKnite S, Aufderheide TP, Lurie KG, Yannopoulos D. Sodium nitroprusside enhanced cardiopulmonary resuscitation prevents post-resuscitation left ventricular dysfunction and improves 24-hour survival and neurological function in a porcine model of prolonged untreated ventricular fibrillation. Resuscitation. 2011;82 Suppl 2:S35-40

Metzger A, Matsuura T, McKnite S, Marino BS, Nadkarni VM, Yannopoulos D. Intrathoracic pressure regulation improves 24-hour survival in a pediatric porcine model of hemorrhagic shock. Pediatr Res. 2011;70:267-271

Lick CJ, Aufderheide TP, Niskanen RA, Steinkamp JE, Davis SP, Nygaard SD, Bemenderfer KK, Gonzales L, Kalla JA, Wald SK, Gillquist DL, Sayre MR, Osaki Holm SY, Oakes DA, Provo TA, Racht EM, Olsen JD, Yannopoulos D, Lurie KG. Take heart america: A comprehensive, community-wide, systems-based approach to the treatment of cardiac arrest. Crit Care Med. 2011;39:26-33

Convertino VA, Ryan KL, Rickards CA, Glorsky SL, Idris AH, Yannopoulos D, Metzger A, Lurie KG. Optimizing the respiratory pump: Harnessing inspiratory resistance to treat systemic hypotension. Respir Care. 2011;56:846-857

Aufderheide TP, Frascone RJ, Wayne MA, Mahoney BD, Swor RA, Domeier RM, Olinger ML, Holcomb RG, Tupper DE, Yannopoulos D, Lurie KG. Standard cardiopulmonary resuscitation versus active compression-decompression cardiopulmonary resuscitation with augmentation of negative intrathoracic pressure for out-of-hospital cardiac arrest: A randomised trial. Lancet. 2011;377:301-311

O'Connor RE, Brady W, Brooks SC, Diercks D, Egan J, Ghaemmaghami C, Menon V, O'Neil BJ, Travers AH, Yannopoulos D. Part 10: Acute coronary syndromes: 2010 american heart association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2010;122:S787-817