Robert Bache, MD

Professor of Medicine
Director, Cardiovascular Research
I am dedicated to providing my patients with as much information about their medical condition as possible so that they can fully participate in choices for their treatment and medical care.

Specialties
Cardiology, Internal Medicine

Medical School
Harvard University, Boston, Massachusetts

Residency
University of Minnesota School of Medicine, Minneapolis, Minnesota

Fellowship
Duke University Medical Center, Durham, North Carolina

Clinical Interests
General cardiology, cardiovascular education, noninvasive/cardiac imaging

Research Interests
Cardiac response to overload states; myocardial hypertrophy and failure, myocardial energy metabolism; coronary vascular response to ischemia

Professional Organizations
American College of Cardiology; Association of American Physicians; Association of University Cardiologists; American Society for Clinical Investigation; American Physiological Society; Fellow of the American Heart Association

Recent Publications
Hall J, Grindle S, Han X, Fermin D, Park S, Chen Y, Bache RJ, Mariash A, Guan Z, Ormaza S, Thompson J, Graziano J, de Sam Lazaro SE, Pan S, Simari RD, Miller LW. Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks. Physiol Genomics 2004; 17:283-291.

Lieu J, Hu Q, Wang Z, Xu C, Wang X, Gong G, Mansoor A, Lee J, Hou M, Zeng L, Zhang JR, Jerosch-Herold M, Guo T,Bache RJ, Zhang J. Autologous stem cell transplantation for myocardial repair. Am J Physiol Heart Circ Physiol 2004; 287:H501-H511.
Hou M, Chen YJ, Traverse JH, Li Y, Barsoum M,Bache RJ. Endothelin-A receptor activity restrains coronary blood flow in the failing heart. J Cardiovasc Pharmacol 2004; 43:764-769

McFalls EO, Hou M,Bache RJ, Best A, Marx D, Sikora J, Ward HB. Activation of p38 MAP kinase and increased glucose metabolism in chronic hibernating swine myocardium. Am J Physiol Heart Circ Physiol 2004; 287; H1328-H1334.

Chen YJ, Park S, Li Y, Missov E, Hou M, Han X, Hall JL, Miller LW,Bache RJ. Alterations of gene expression in the failing myocardium following left ventricular assist device support. Physiol Genomics 2003; 14:251-260.

Lieu J, Hu Q, Wang Z, Xu C, Wang X, Gong G, Mansoor A, Lee J, Hou M, Zeng L, Zhang JR, Jerosch-Herold M, Guo T,BacheRJ, Zhang J. Autologous stem cell transplantation for myocardial repair. Am J Physiol Heart Circ Physiol 2004; 287:H501-H511.

Chen Y, Li Y, Zhang P, Traverse JH, Hou M, Xu X, Kimoto M,Bache RJ. Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts. Am J Physiol Heart Circ Physiol. 2005; 289:H2212-9.

Chen Y, Hou M, Li Y, Traverse JH, Zhang P, Salvemini D, Fukai T,Bache RJ. Increased superoxide production causes coronary endothelial dysfunction and depressed oxygen consumption in the failing heart. Am J Physiol Heart Circ Physiol. 2005; 288:H133-41.

Hu Q, Wang X, Lee J, Mansoor A, Liu J, Zeng L, Swingen C, Zhang G, Feygin J, Ochiai K, Bransford TL, From AH,Bache RJ, Zhang J. Profound bioenergetic abnormalities in peri-infarct myocardial regions. Am J Physiol Heart Circ Physiol. 2006; 291:H648-57. Epub 2006 Mar 31.

Zeng L, Hu Q, Wang X, Mansoor A, Lee J, Feygin J, Zhang G, Suntharalingam P, Boozer S, Mhashilkar A, Panetta CJ, Swingen C, Deans R, From AH,BacheRJ, Verfaillie CM, Zhang J. Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling. Circulation. 2007; 115:1866-75. Epub 2007 Mar 26.

Liu Z, Jiang Y, Hao H, Gupta K, Xu J, Chu L, McFalls EO, Zweier JL, Verfaillie CM,Bache RJ. Endothelial nitric oxide synthase is dynamically expressed during bone marrow stem cell differentiation into endothelial cells. Am J Physiol Heart Circ Physiol. 2007; 293:H1760-H1765. Epub 2007 Jun 1.

Zeng L, Hu Q, Wang X, Mansoor A, Lee J, Feygin J, Zhang G, Suntharalingam P, Boozer S, Mhashilkar A, Panetta CJ, Swingen C, Deans R, From AH,Bache RJ, Verfaillie CM, Zhang J. Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling. Circulation. 2007; 115:1866-75. Epub 2007 Mar 26.

Traverse JH, Chen Y, Hou M, Li Y, Bache RJ. Effect of K+ATP channel and adenosine receptor blockade during rest and exercise in congestive heart failure. Circ Res. 2007; 100:1643-9. Epub 2007 May 3.

Lu Z, Xu X, Hu X, Zhu G, Zhang P, van Deel ED, French JP, Fassett JT, Oury TD, Bache RJ, Chen Y. Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. Hypertension. 2008; 51:19-25. Epub 2007 Nov 12.

Van Deel ED, Lu Z, Xu X, Zhu G, Hu X, Oury TD, Bache RJ, Duncker DJ, Chen Y. Extracellular superoxide dismutase protects the heart against oxidative stress and hypertrophy after myocardial infarction. Free Radic Biol Med. 2007 Dec 15; [Epub ahead of print].

Xu X, Fassett J, Hu X, Zhu G, Lu Z, Li Y, Schnermann J, Bache RJ, Chen Y. Ecto-5'-nucleotidase deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction. Hypertension. 2008 Jun; 51:1557-64. Epub 2008 Apr 7.

Duncker DJ, Bache RJ. Regulation of coronary blood flow during exercise. Physiol Rev. 2008 Jul;88:1009-86.

Wu F, Zhang EY, Zhang J, Bache RJ, Beard DA. Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischemic hearts. J Physiol. 2008 Jul 10. [Epub ahead of print].