Andrew Boyle, M.D.

Associate Professor of Medicine
Medical Director of Heart Failure, Cardiac Transplantation, and Mechanical Circulatory Support

Specialties
Cardiology, Heart failure and transplantation

Medical School
University of Ottawa, Ottawa, Ontario

Residency
Mayo Clinic, Rochester, Minnesota

Fellowship
The Cleveland Clinic, Cleveland, Ohio

Clinical Interests
Heart failure and transplantation, mechanical circulatory support, diagnostic angiography, and cardiac intensive care

Research Interests
Mechanical circulatory support , treatment of acute and chronic heart failure, ultrafiltration

Recent Publications
John R, Kamdar F, Liao K, Colvin-Adams M, Boyle A , and Joyce L. Improved survival and decreasing incidence of adverse events using the HeartMate II left ventricular assist device as a bridge-to-transplant. Annals of Thoracic Surgery 2008, 86:1227-1235.

Dahle T, Sobotka P, and Boyle A .  A practical guide for ultrafiltration in acute decompensated heart failure.  Congestive Heart Failure 2007; 14:83-88.

Garcia S, Kamdar F, Boyle A , Colvin-Adams M, Liao K, Joyce L, John R. Effects of pulsatile and continuous-flow left ventricular assist devices on left ventricular unloading.  Journal of Heart and Lung Transplantation 2007;27: 261-267.

Miller L, Pagani F, Russell S, John R, Boyle A , Aaronson K, Conte J, Naka Y, Mancini D, Delgado R, MacGillivray T, Farrar D, Frazier O for the HeartMate II Clinical Investigators.  A continuous flow ventricular assist device in patients awaiting heart transplantation.  New England Journal of Medicine 2007; 357: 885-896.

John R, Lietz K, Liao K, Kamdar F, Colvin-Adams M, Boyle A , Miller L, and Joyce L.  Experience with the Levitronix-CentriMag ventricular assist device system as a bridge-to-decision in patients with refractory acute cardiogenic shock and multiple organ failure.  Journal of Thoracic and Cardiovascular Surgery  2007; 134: 351-358.

Boyle A , Maurer M, and Sobotka P.  Myocellular and interstitial edema and circulating volume expansion as a cause of morbidity and mortality in heart failure.  Journal of Cardiac Failure  2007; 13: 133-136.

Dahle T, Blake D, Ali S, Olinger C, Bunte M, and Boyle A .  Large volume ultrafiltration for acute decompensated heart failure using standard peripheral intravenous catheters.  Journal of Cardiac Failure 2006; 12:349-352.

Boyle A and Sobotka P.  Redefining the therapeutic objective in decompensated heart failure:  Hemoconcentration as a surrogate for plasma refill rate.  Journal of Cardiac Failure 2006; 12: 247-249.

Boyle A .  Ultrafiltration for acute decompensated heart failure.  Expert Review of Medical Devices 2005; 2(6): 689-697.

Bart BA, Boyle A , Bank A, Anand, et al.  Ultrafiltration versus usual care for hospitalized patients with heart failure:  The relief for acutely fluid-overloaded patients with decompensated congestive heart failure (RAPID-CHF) trial.  Journal of the American College of Cardiology 2005; 46(11): 2043-2046.

Boyle A and Colvin-Adams M.  Recipient selection and management.  Seminars in Thoracic and Cardiovascular Surgery.  Update on Heart Transplantation. Seminars in Thoracic and Cardiovascular Surgery  2004;  16 (4):  358-363.

Book Chapters
Hobbs R and Boyle A .  Heart Failure.  In 2009 Current Clinical Medicine. Elsevier Publishing 2008.  Edited by William Casey, MD.  Chapter 2: pages 113-120.

Boyle A .  Contemporary Management of Congestive Heart Failure.  In Cardiac Pacing and Defibrillation - Principle and Practice.  People's Medical Publishing House 2008.  Edited by Fei Lu, MD and David Benditt, MD. Chapter 4.1:  pages 395 - 400.

Lu F, Wu Y, and Boyle A .  Physiologic Pacing and Cardiac Resynchronization Therapy.  In Cardiac Pacing and Defibrillation - Principle and Practice. People's Medical Publishing House 2008.  Edited by Fei Lu, MD and David Benditt, MD. Chapter 4.2:  pages 401 - 425.

Boyle A .  The Heart and Infectious Diseases.  In Textbook of Cardiovascular Medicine 3rd Edition.  Lippincott, Williams, & Wilkins 2007.  Edited by Eric Topol, MD.  Chapter 35F:  pages 656 - 668.

Boyle A .  Cardiac Transplantation.  In Manual of Cardiovascular Medicine. Second Edition.  Lippincott, Williams, & Wilkins 2004.  Edited by Brian Griffin MD, and Eric Topol MD. Chapter 13:  pages 161 - 177.

Abstracts:

Pamboukian S, Borgaev R, Russell S, Boyle A , Moazami N, Chen L, Farrar D, and Pagani F.  Continuous Flow Left Ventricular Assist Device in Women with Advanced Heart Failure:  Results After One Year of Support.  American Heart Association Scientfic Sessions.  New Orleans, LA.  11/08.

Boyle A , Ascheim D, Kormos R, Russo M, John R, Naka Y, Gelijns A, Hong K, Parides M, Moskowitz A, and Teuteberg J.  LVAD for Less Acutely Ill Patients: Do Current Data Support the Strategy?  European Society of Cardiology Heart Failure Congress. Milan, Italy.  6/08.

Crossley G, Boyle A , Berman B, Alsheikh T, Sodowick B, Johnson S, Vitense H, Sherfesee L, and Mead H.  The Burden of Following Implantable Cardioverter Defibrillators - from a Patient and Caregiver Perspective.  Heart Rhythm Society Scientific Sessions.  San Francisco, CA.  5/08.

Boyle A , Griffith B, Ascheim D, Naka Y, Teuteberg J, Feller E, Joyce L, Mancini D, John R, Woodard J, Moquette E, Hong K, Parides M, Moskowitz A, Gelijns A, Rose E, and Kormos R.  The VentrAssist LVAD as a Bridge to Cardiac Transplantation:  Results of the US Feasibility Trial. International Society for Heart and Lung Transplantation 28th Annual Meeting and Scientific Sessions.  Boston, MA.  4/08.

Kamdar F, Boyle A , Colvin- Adams M, Pritzker M, Missov E, Liao K, Joyce L, and John R.  The Effect of Centrifugal, Axial, and Pulsatile Left Ventricular Assist Device Support on End-Organ Function in Heart Failure Patients.  International Society for Heart and Lung Transplantation 28th Annual Meeting and Scientific Sessions.  Boston, MA.  4/08.

John R, Boyle A , MacGillivray T, Rogers J, Chen L, Goldstein D, Dembitsky W, Farrar D, and Pagani F.  Can Continuous Flow LVADs Provide a Similar Level of Circulatory Support as Pulsatile LVADs for Large Patients?  International Society for Heart and Lung Transplantation 28th Annual Meeting and Scientific Sessions.  Boston, MA.  4/08.

Conte J, Miller L, Pagani F, Aaronson, Russell S, John R, Boyle A , Naka Y, Mancini D, Delgado R, MacGillivray T, Farrar D, Frazier O.  One Year Followup with a Continuous Flow LVAD as a Bridge to Heart Transplantation. International Society for Heart and Lung Transplantation 28th Annual Meeting and Scientific Sessions.  Boston, MA.  4/08.

John R, Kamdar F, Boyle A , Colvin-Adams M, Pritzker M, Missov E, Liao K, Joyce L.  Efficacy of Continuous-Flow Ventricular Assist Devices in Heart Failure Patients with Severe Pulmonary Hypertension.  International Society for Heart and Lung Transplantation 28th Annual Meeting and Scientific Sessions.  Boston, MA.  4/08.

Boyle A , Russell S, John R, Chen L, Aaronson K, Farrar D, and Rogers J. Comparing Improvements in Functional Capacity in NYHA Class IV Patients Between a Continuous Flow Left Ventricular Assist Device and Cardiac Resynchronization Therapy.  American College of Cardiology 57th Annual Scientific Sessions.  Chicago, IL.  3/08.

Rogers J, Miller L, Pagani F, Aaronson K, John R, Boyle A , Milano C, Russell S, Conte J, Naka Y, Mancini D, Bogaev R, MacGillivray T, Farrar D, Frazier O.  Continuous Flow Left Ventricular Assist Device a Bridge to Heart Transplantation:  Long Term Outcomes.  American College of Cardiology 57th Annual Scientific Sessions.  Chicago, IL.  3/08.

Masri S, Colvin- Adams M, Boyle A , Toninato C, Joyce L, Liao K, Nguyen J, John R.  High central pressure is a marker of renal failure in patients with normal cardiac output.  American College of Cardiology 57th Annual Scientific Sessions.  Chicago, IL.  3/08.

Boyle A , Russell S, Teuteberg J, Moazami N, Moore S, Slaughter M, Farrar D, and John R, for the HeartMate II investigators.  Low Thromboembolism and Pump Thrombosis Potential of the HeartMate II LVAD.  American Heart Association Annual Scientific Sessions, Orlando, FL 11/07.

Pagani F, Miller L, Russell S, John R, Boyle A , Aaronson K, Conte J, Naka Y, Mancini D, Delgado R, MacGillivray T, Farrar D, and Frazier O.  Left ventricular assist device therapy with the HeartMate II continuous flow rotary pump as a bridge to heart transplantation.  American Heart Association Scientific Sessions, Orlando, FL 11/07.

Olinger C, Sobotka P, Ali S, Dahle T, Blake D, Bunte M, and Boyle A . Variability of Natriuretic Resistance to Loop Diuretics in Acute Decompensated Heart Failure.  Heart Failure Society of America 11th Annual Scientific Meeting, Washington, DC 9/07.

Dyke D, Pagani F, Russell S, Boyle A , Farrar D, and Aaronson K.  HeartMate II continuous flow left ventricular assist device improves functional capacity and quality of life. Heart Failure Society of America 11th Annual Scientific Meeting, Washington, DC 9/07.

Russell S, Dyke, D, Aranda J, Boyle A , Rogers J, Farrar D, and Conte J.  The HeartMate II continuous flow LVAD is associated with improvement of renal and hepatic function in advanced heart failure patients.  Heart Failure Society of America 11th Annual Scientific Meeting, Washington, DC 9/07.

Garcia S, Colvin-Adams M, Boyle A , Joyce L, and John R.  Long-term Outcomes after the Use of Left Ventricular Assist Devices.  Heart Failure Society of America 11th Annual Scientific Meeting, Washington, DC 9/07.

Miller L, Pagani F, Russell S, John R, Boyle A , Aaronson K, Conte J, Naka Y, Mancini D, Delgado R, MacGillvray T, Farrar D and Frazier O.  Multicenter clinical evaluation of the HeartMate II continuous flow left ventricular assist system in patients awaiting heart transplantation.  American College of Cardiology 56th Annual Scientific Sessions. New Orleans, LA  3/27/2007.

Dahle T, Blake D, Ali S, Olinger C, Bunte M, and Boyle A .  Large volume ultrafiltration in acute decompensated heart failure using standard peripheral intravenous catheters.  Heart Failure Society of America Annual Scientific Meeting.  Seattle, WA  9/11/06.

Ali S, Olinger C, Sobotka P, Bernard S, Dahle T, Bunte M, Blake D, Campbell S, and Boyle A .  Enhanced sodium extraction with ultrafiltration compared to intravenous diuretics.  Heart Failure Society of America Annual Scientific Meeting.  Seattle, WA  9/11/06.

John R, Liao K, Lietz K, Colvin-Adams M, Boyle A , Miller L, and Joyce L.  Use of the Levitronix CentriMag Ventricular Assist Device (VAD) for the Treatment of Refractory Cariogenic Shock in Patients with End-Stage Heart Failure. International Society of Heart and Lung Transplantation 26th Annual Meeting and Scientific Sessions.  Madrid, Spain  4/2006.

Bart B, Boyle A , Bank A, Anand I, Olivari M, Kraemer M, Mackedanz S, Schollmeyer M, Goldsmith S.  Randomized Controlled Trial of Ultrafiltration versus Usual Care for Hospitalized Patients with Heart Failure:  Preliminary Report of the RAPID trial.  Heart Failure Society of America.  Toronto 9/04.

Colvin-Adams M, Park S, Thompson J, Boyle A , Ormaza S, Liao K, and Miller L. Left Ventricular Recovery Following Support with Left Ventricular Assist Device.  The International Society for Heart and Lung Transplantation 24th Annual Meeting and Scientific Sessions.  San Francisco, 4/2004.

Colvin-Adams M, Park S, Ormaza S, Boyle A , Cytron J, Thompson J, Liao K, and Miller L.  The Impact on Infection of Routine Use of an Abdominal Binder Following Implantation of a Ventricular Assist Device.  American Transplant Congress.  Washington, DC  6/2/03.

Boyle A , Park S, Colvin-Adams M, Liao K, Ormaza S, Thompson J, and Miller L. Cerebral Hypoperfusion Syndrome Following LVAD Implantation.  International Society for Heart and Lung Transplantation 23rd Annual Meeting and Scientific Sessions.  Vienna, Austria.  4/11/2003.

Boyle A , Park S, Colvin-Adams M, Ormaza S, Liao K, Thompson J, and Miller L. Predictors of Poor RV Function Following LVAD Implantation.  International Society for Heart and Lung Transplantation 23rd Annual Meeting and Scientific Sessions.  Vienna, Austria.  4/11/2003.