YingJie Chen, M.D., Ph.D.

Assistant Professor of Medicine

Education
M.D., Neimonggu Medical College, China  1986
MS, National Research Institute of Sports Science 1991
Ph.D., University of Minnesota 1999
Postdoctoral Training, Cardiology, Department of Medicine, University of Minnesota

Research Interests
My general research interest is myocardial hypertrophy, congestive heart failure and exercise-induced muscle fatigue. The major research activities of my laboratory are focusing on factors regulating myocardial mitochondria biogenesis, and the effect of dimethylarginine dimethylaminohydrolase and oxidative stress on development of congestive heart failure.

Publications
Chen YJ , Traverse JH, Du R, Hou M, Bache RJ. Nitric oxide modulates myocardial oxygen consumption in the failing heart. Circulation 2002;106:273-9.

Chen YJ , Traverse JH, Du R, Bache RJ. Effect of PDE5 inhibition on coronary hemodynamics in pacing induced heart failure. Am J Physiol 2003;284:H1513-H1520.

Chen Y , Park S, Li Y, Missov E, Hou M, Han X, Hall JL, Miller LW, Bache RJ.  Alterations of gene expression in the failing myocardium following left ventricular assist device support.  Physiol Genomics 2003;14:251-260.

Chen Y , Traverse J, Bache RJ. Effect of PDE-5 inhibition on coronary blood flow in experimental animals. Heart Disease and Erictile Dysfunction. Edt RA. Kloner. 2004 Human Press Inc. New Jersey.

Chen YJ , Hou M, Li Y, Traverse JH, Fukai T, Bache RJ.  Increased superoxide production causes coronary endothelial dysfunction and depressed oxygen consumption in the failing heart.  Am J Physiol Heart Circ Physiol. 2005;288:H133-H141.

Chen Y , Li Y, Zhang P, Traverse JH, Hou M, Xu X, Kimoto M, Bache RJ. Dimethylarginine dimethylamino-hydrolase and endothelial dysfunction in failing hearts. Am J Physiol Heart Circ Physiol. 2005; 289:H2212-9.

Chen Y , Hou M, Li Y, Ping Zhang, Traverse JH, Bache RJ. Increased superoxide production causes coronary endothelial dysfunction and depressed oxygen consumption in the failing heart. Am J Physiol Heart Circ Physiol. 2005; 288:H133-41.

Traverse JH, Chen Y , Hou M, Li Y, Bache RJ. Effect of K+ATP Channel and Adenosine Receptor Blockade During Rest and Exercise in Congestive Heart Failure. Circ Res. 2007; 2007; 100(11):1643-9.

Bryan PM, Xu X, Dickey DM, Chen Y , Potter LR.  Renal hyporesponsiveness to atrial natriuretic peptide in congestive heart failure results from reduced atrial natriuretic peptide receptor concentrations. Am J Physiol Renal Physiol. 2007 May;292(5):F1636-44.

Dickey DM, Flora DR, Bryan PM, Xu X, Chen Y , Potter LR. Differential Regulation of Membrane Guanylyl Cyclases in Congestive Heart Failure: NPR-B, Not NPR-A, Is the Predominant Natriuretic Peptide Receptor in the Failing Heart. Endocrinology. 2007 Jul;148(7):3518-22.

Zhang P, Xu X, Hu X, van Deel ED, Zhu G, Chen Y . Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circ Res. 2007 Apr 13;100(7):1089-98. 

Zhongbing Lu, Xin Xu , Xinli Hu, Guangshuo Zhu, Ping Zhang, Elza D. van Deel, Joel P. French, John T. Fassett, Tim D. Oury, Robert J. Bache, Chen Y . Extracellular Superoxide dismutase deficiency exacerbates pressure overload induced left ventricular hypertrophy and dysfunction. Hypertension. 2008  51:19-25 

van Deel ED, Lu  Z, Xu X, Zhu G, Hu X, Oury TD, Bache RJ, Duncker DJ, Chen Y . Extracellular SOD protects the heart against oxidative stress and hypertrophy after myocardial infarction. Free Radical Biology and Medicine. 2008, DOI:10.1016/j.freeradbiomed.2007.12.007

Xu X, Fassett J, Hu XL, Zhu GS, Schnermann J, Bache RJ, and Chen Y . Endogenous adensine protects the hart from severe systolic overload induced ventricular hypertrophy and congestive heart failure. Hypertension (accepted for issue of June 2008).