Daniel Duprez, MD, PhD

Professor of Medicine

Practice Philosophy

“I work in a hospital, but the major part of my research is trying to find ways to keep people out of the hospital.” Daniel Duprez, M.D.

At the University of Ghent (Belgium), Dr. Duprez completed medical school, a residency, a cardiology fellowship, a doctorate in biomedical sciences, and a Ph.D. in cardiology. He also completed a physiology fellowship at the Mayo Clinic in Rochester, Minnesota.

From research studies to clinical practice, Dr. Daniel Duprez’s cardiology interests span the prevention of cardiovascular disease in the general population to its occurrence in patients with HIV. Dr. Duprez is the author of more than 200 articles, abstracts, and book chapters, and lectures nationally and internationally on a wide range of cardiology topics.

An internationally-renowned expert in vascular biology, Dr. Duprez’s current research involves arterial mechanics and stiffness, biomarkers for early cardiovascular disease, lipoproteins, neurohormonal factors and hypertension, HIV and cardiovascular disease, and clinical-trials events evaluation. His research experience also includes studies involving mathematical modeling, drug delivery, device design, biomechanics, and biomedical imaging.

Dr. Duprez’s primary clinical interests are cardiovascular prevention, hypertension, lipid disorders, and vascular disease. At the Rasmussen Center for Cardiovascular Disease Prevention, Dr. Duprez and colleagues perform a series of non-invasive clinical tests that detect cardiovascular disease in its earliest stages, including measuring arterial elasticity and examining retinal vessels. Each patient evaluated receives a Rasmussen risk score. According to Dr. Duprez,

“We’re finding that the Rasmussen score is much more predictive of cardiac events than the traditional risk factors of age, blood pressure, blood sugar, smoking status, and cholesterol.”

Professional Organizations

• American College of Cardiology, Fellow
• American Heart Association, Fellow
• American Society of Hypertension, member
• European Society of Cardiology, Fellow
• International Society of Cardiovascular Pharmacotherapy (Governor representing the U.S.A.)
• International Society of Hypertension, member
• International Union of Angiology
• National Lipid Association, member

Journals (Editing and Review)

• Circulation, reviewer
  
• Hypertension, Editorial Board
  
• Journal of the American College of Cardiology, reviewer
  
• Europrean Heart Journal, reviewer

Selected Publications

Peralta CA, Adeney KL, Shlipack, MG, Jacobs Jr D, Duprez D, Bluemke D, Polak J, Psaty B, Kestenbaum BR. Structural and Functional Vascular Alterations and Incident Hypertension in Normotensive Adults - The Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 2010;171:63-71

Duprez DA, Munger MA, Botha J, Keefe DL, Charney AN. Aliskiren for Geriatric Lowering of Systolic Hypertension (AGELESS): A Randomized Controlled Trial. J Hum Hypertens. 2010;24:600-608

Duprez DA. Arterial Stiffness and Endothelial Function, Key Players in Vascular Health. Hypertension 2010;55:612-613

Baker J, Ayenew W, Quick H, Hullsiek KH, Tracy R, Henry K, Duprez D, Neaton JD. High-Density Lipoprotein Particles and Markers of Inflammation and Thrombotic Activity in Patients with Untreated HIV Infection. J Infec Dis 201:285-292

Neuhaus J, Jacobs Jr DR, Baker JV, Calmy A, Duprez D, La Rosa A, Lewis H Kuller LH, Pett SL, Ristola M, Ross MJ, Shlipak MG, Tracy R, Neaton JD. Markers of Inflammation, Coagulation and Renal Function Are Elevated in Adults with HIV Infection. J Infec Dis 2010;201:1788-1795

Lampe F, Duprez DA, Kuller LH, Tracy R, Otvos J, Stroes E, Cooper DA, Hoy J, Paton NI, Friis-Moller N, Neuhaus J, Liappis AP, Phillips AN for INSIGHT SMART Study Group. Changes in lipids and lipoprotein particle concentrations following interruption of antiretroviral therapy. J Acquir Immune Defic Syndr. 2010;54:275-284

Garcia S, Akbar MS, Ali S, Kamdar F, Tsai MY, Duprez DA. N-Terminal Pro-B-type Natriuretic Peptide Predicts Mortality in Patients with Left Ventricular Hypertrophy. Int J Cardiol. 2010;143:349-352

Baker J, Harrison Q, Huppler Hullsiek K, Tracy R, Duprez D, Henry K, Neaton JD. Interleukin-6 and D-dimer levels are associated with vascular dysfunction in patients with untreated HIV-infection. HIV Medicine 2010;11:608-609

Duprez DA. Is Vascular Stiffness a Target for Therapy? Cardiovasc Drugs and Therapy 2010; 24:305-310

Duprez D. Coronary Artery Calcification, an Improvement in Risk Classification, Need for Re-Appraisal. J Am Coll Cardiol. 2010;56:1415-1417

Baker J, Duprez D. Biomarkers and Associated Cardiovascular Disease. Curr Opinion in HIV and AIDS 2010;5:511-516

Brumback LC, Jacobs Jr DR, Dermonda N, Chenc H, Duprez DA. Reproducibility of Arterial Elasticity Parameters Derived from the Radial Artery Diastolic Pulse Contour Analysis: The Multi-Ethnic Study of Atherosclerosis. Blood Press Monit. 2010;15;312-315

Lifson AR, Belloso WH, Davey RT, Duprez D, Gatell JM, Hoy JF, Krum EA, Nelson R, Pedersen C, Perez G, Price RW, Prineas RJ, Rhame F, Sampson JH, Worley J. Development of Diagnostic Criteria for Serious Non-Aids Events in HIV Clinical Trials. The Insight Study Group. HIV Clinical Trials 2010;11:205-219