Daniel Duprez, MD, PhD

Professor of Medicine, Donald and Patricia Garofalo Chair in Preventive Cardiology, Professor of Epidemiology and Community Health

Practice Philosophy 

“I work in a hospital, but the major part of my research is trying to find ways to keep people out of the hospital.” Daniel Duprez, M.D., Ph.D.

At the University of Ghent (Belgium), Dr. Duprez completed medical school, a residency, a cardiology fellowship, a doctorate in biomedical sciences, and a Ph.D. in cardiology. He also completed a physiology fellowship at the Mayo Clinic in Rochester, Minnesota.

From research studies to clinical practice, Dr. Daniel Duprez’s cardiology interests span the prevention of cardiovascular disease in the general population to its occurrence in patients with organ transplants, patients with HIV, . Dr. Duprez is the author of more than 250 articles and 55 book chapters, and more than 1000 lectures nationally and internationally on a wide range of cardiology topics.

An internationally-renowned expert in vascular biology, Dr. Duprez’s current research involves arterial mechanics and stiffness, biomarkers for early cardiovascular disease, lipoproteins, neurohormonal factors and hypertension, HIV and cardiovascular disease, and clinical-trials events evaluation. His research experience also includes studies involving mathematical modeling, drug delivery, device design, biomechanics, and biomedical imaging. He is actively involved in the design and perform clinical trials in phase II, III and IV. He has also multiple cardiovascular research NIH grants. He serves at several events committees of national and international trials. He serves at several scientific grant review committees in USA, Belgium, France, Italy, Canada and Singapore. He is member of the editorial board of the Hypertension and Vascular Risk and Health Management.

Dr. Duprez’s primary clinical interests are cardiovascular prevention, hypertension, lipid disorders, and vascular disease. At the Rasmussen Center for Cardiovascular Disease Prevention, Dr. Duprez and colleagues perform a series of non-invasive clinical tests that detect cardiovascular disease in its earliest stages.

“We’re finding that the Rasmussen score is much more predictive of cardiac events than the traditional risk factors of age, blood pressure, blood sugar, smoking status, and cholesterol.” Daniel Duprez, M.D., Ph.D.

Professional Organizations

• American College of Cardiology, Fellow
• American Heart Association, Fellow
• European Society of Cardiology, Fellow
• American Society of Hypertension, Fellow
• National Lipid Association, Fellow
• International Society of Cardiovascular Pharmacotherapy (Governor representing the U.S.A.)

Selected Publications

2012

• Duprez DA. Arterial Stiffness/Elasticity in the Contribution to Progression of Heart Failure. Heart Fail Clin. 2012;8:135-141.
• Peralta CA, Jacobs Jr DR, Katz, Ix JH, Madero M, Duprez DA, Sarnak MJ, Criqui MH, Kramer JH, Palmas W, Herrington D, Shlipak MG. Association of Pulse Pressure, Arterial Elasticity, and Endothelial Function With Kidney Function Decline Among Adults With Estimated GFR >60 mL/min/1.73 m(2): The Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 2012;59:41-49.
• Gross MD, Bielinski SJ, Suarez-Lopez JR, Reiner AP, Bailey K, Thyagarajan B, Carr JJ, Duprez DA, Jacobs DR. Circulating Soluble Intercellular Adhesion Molecule 1 (sICAM-1) and Subclinical Atherosclerosis: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Clin Chem. 2012;58:411-420.
• Jacobs Jr DR, Yatsuya H, Hearst MO, Thyagarajan B, Kalhan R, Rosenberg S, Smith LJ, Barr RG, Duprez D. Rate of Decline of Forced Vital Capacity Predicts Future Arterial Hypertension: The Coronary Artery Risk Development in Young Adults Study. Hypertension 2012;59:219-225.
• Weintraub HS, Duprez DA, Cushman WC, Zappe DH, Purkayastha D, Samuel R, Izzo Jr JL. Antihypertensive Response to Thiazide Diuretic or Angiotensin Receptor Blocker in Elderly Hypertensives Is Not Influenced by Pretreatment Plasma Renin Activity. Cardiovasc Drugs Ther 2012;26;145-155.
• Cushman WC, Duprez DA, Weintraub HS, Purkayastha D, Zappe D, Samuel, Izzo Jr JL. Home and Clinic Blood Pressure Responses in Elderly Individuals with Systolic Hypertension. J Am Soc Hypertens. 2012;6:210-218.
• Baker JV, Neuhaus J, Duprez D, Freiberg M, Bernardino JI, Badley AD, Nixon DE, Lundgren JD, Tracy RP, Neaton JD; for the INSIGHT SMART Study Group. HIV Replication, Inflammation, and the Effect of Starting Antiretroviral Therapy on Plasma Asymmetric Dimethylarginine, a Novel Marker of Endothelial Dysfunction. J Acquir Immune Defic Syndr. 2012;60:128-134.
• Mulrooney DA, Blaes AH, Duprez D. Vascular Injury in Cancer Survivors. J Cardiovasc Transl Res. 2012;5:287-295.
• Hebl V, Zahkarova M, Canoniero M, Duprez D, Garcia S. Correlation of natriuretic peptides and inferior vena cava size in patients with congestive heart failure. Vasc Health Risk Manag. 2012;8:213-218.
• Hall JL, Duprez DA, Barac A, Rich SS. A Review of Genetics, Arterial Stiffness, and Blood Pressure in African Americans. J Cardiovasc Transl Res. 2012;5:302-308.
• Duprez D, Jacobs Jr DR. Arterial stiffness and left ventricular diastolic function, does sex matter? Hypertension 2012;60:283-284.

2011

• Soliman EZ, Lundgren JD, Roediger MP, Duprez DA, Temesgen Z, Bickel M, Shlay JC, Somboonwit C, Reis P, Stein JH, Neaton JD for the INSIGHT SMART Study group. Boosted Protease Inhibitors and the Electrocardiographic Measures of QT and PR Durations in the Strategies for Management of Antiretroviral Therapy (SMART) Trial. AIDS 2011;25:367-377.
• Baker JV, Neuhaus J, Duprez D, Kuller LH, Tracy R, Belloso WH, De Wit S, Drummond F, Lane HC, Lederberger B, Lundgren J, Nixon DE, Paton NI, Neaton JD for the INSIGHT SMART Study Group. Changes in inflammatory and coagulation biomarkers: a randomized comparison of immediate versus deferred antiretroviral therapy in patients with HIV infection. J Acquir Immune Defic Syndr. 2011;56;36-43.
• Duprez DA, Neuhaus J, Tracy R, Kuller LH, Deeks SG, Orkin C, Stoehr A, Wooley IJ, Neaton JD for the INSIGHT SMART Group. N-Terminal-proB-type Natriuretic Peptide (NT-proBNP) predicts cardiovascular disease events in HIV-infected patients: results of the SMART study. AIDS 2011;25:651-657.
• McAllister D, MacNee W, Duprez D, Hoffmann EA, Vogel-Claussen J, Criqui MH, Budoff M, Jiang R, Bluemke DA, Barr RG. Pulmonary Function is Associated with Distal Aortic Calcium, Not Proximal Aortic Distensibility. MESA Lung Study. J Chron. Obstructive Pulmonary Disease 2011;8:71-78.
• Duprez DA, Jacobs Jr DR, Lutsey PL, Bluemke DA, Brumback LC, Polak JF, Carmen A. Peralta CA, Greenland P, Kronmal RA. Association of Small Artery Elasticity with Incident Cardiovascular Disease in Older Adults: The Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol. 2011;174:528-536.
• Wright R, Duprez D, Purkayastha D, Samuel R, Ferdinand KC. A Combination Angiotensin-Receptor Blocker (ARB)/Calcium Channel Blocker with HCTZ vs the Maximal Recommended Dose of an ARB with HCTZ in Patients with Stage 2 Hypertension: The EXALT (Exforge As Compared to Losartan Treatment in Stage 2 Systolic Hypertension) Study. J Clin Hypertens 2011;13:588-597.
• Duprez DA, Florea, Zhong W, Grandits GA, Hawthorne CK, Hoke L, Cohn JN. Vascular and Cardiac Functional and Structural Screening to Identify Risk of Future Morbid Events: Preliminary Observations. J Am Soc Hypertens. 2011;5:401-409.
• Duprez D, Weintraub HS, Cushman WC, Purkayastha D, Zappe D, Samuel R, Izzo Jr JL. Effect of Valsartan, Hydrochlorothiazide, and Their Combination on 24-Hour Ambulatory Blood Pressure Response in Elderly Indivisuals With Systolic Hypertension: a ValVET Substudy. Blood Press Monit. 2011;16:186-196.
• Izzo Jr JL, Weintraub HS, Duprez DA, Purkayastha D, Zappe D, Samuel R, Cushman WC. Treating Systolic Hypertension in the Very Elderly With Valsartan-Hydrochlorothiazidevs Either Monotherapy: ValVET Primary Results. J Clin Hypertens. 2011;13:722-730.
• Baker JV, Neuhaus J, Duprez D, Cooper DA, Hoy J, Kuller L, Lampe FC, Liappis A, Friss-Moller N, Otvos J, Paton NI, Tracy R, Neaton JD; for the INSIGHT SMART Study Group. Inflammation Predicts Changes in High-Density Lipoprotein Particles and Apolipoprotein A1 Following Initation of Antiretroviral Therapy. AIDS. 2011;25:2133-2142.
• Soliman EZ, Prineas RJ, Roediger MP, Duprez DA, Boccara F, Christoph Boesecke C, Stephan C, Hodder S, Stein JH, Lundgren JD, Neaton JD , on behalf of the SMART/INSIGHT study group. Prevalence and Prognostic Significance of ECG Abnormalities in HIV-infected Patients: Results from the Strategies for Management of Antiretroviral Therapy (SMART) Study. J Electrocardiology 2011;44:779-785.
• Duprez D, Ferdinand K, Purkayastha D, Samuel R, Wright R. Ambulatory blood pressure to triple therapy with an angiotensin-receptor blocker (ARB), calcium-channel blocker (CCB), and HCTZ versus dual therapy with an ARB and HCTZ. Vascular Health and Risk Management 2011;7:701-708.
• Wassel CL, Jacobs Jr DR, Duprez DA, Criqui MH, Peralta CA.L. Association of Self-Reported Race/Ethnicity And Genetic Ancestry with Arterial Elasticity: The Multi-Ethnic Study Of Atherosclerosis(MESA). J Am Soc Hypertens. 2011;5:463-72.

2010

• Peralta CA, Adeney KL, Shlipack, MG, Jacobs Jr D, Duprez D, Bluemke D, Polak J, Psaty B, Kestenbaum BR. Structural and Functional Vascular Alterations and Incident Hypertension in Normotensive Adults - The Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 2010;171:63-71.
• Duprez DA, Munger MA, Botha J, Keefe DL, Charney AN. Aliskiren for Geriatric Lowering of Systolic Hypertension (AGELESS): A Randomized Controlled Trial. J Hum Hypertens. 2010;24:600-608.
• Duprez DA. Arterial Stiffness and Endothelial Function, Key Players in Vascular Health. Hypertension 2010;55:612-613.
• Baker J, Ayenew W, Quick H, Hullsiek KH, Tracy R, Henry K, Duprez D, Neaton JD. High-Density Lipoprotein Particles and Markers of Inflammation and Thrombotic Activity in Patients with Untreated HIV Infection. J Infec Dis 201:285-292.
• Neuhaus J, Jacobs Jr DR, Baker JV, Calmy A, Duprez D, La Rosa A, Lewis H Kuller LH, Pett SL, Ristola M, Ross MJ, Shlipak MG, Tracy R, Neaton JD. Markers of Inflammation, Coagulation and Renal Function Are Elevated in Adults with HIV Infection. J Infec Dis 2010;201:1788-1795.
• Lampe F, Duprez DA, Kuller LH, Tracy R, Otvos J, Stroes E, Cooper DA, Hoy J, Paton NI, Friis-Moller N, Neuhaus J, Liappis AP, Phillips AN for INSIGHT SMART Study Group. Changes in lipids and lipoprotein particle concentrations following interruption of antiretroviral therapy. J Acquir Immune Defic Syndr. 2010;54:275-284.
• Garcia S, Akbar MS, Ali S, Kamdar F, Tsai MY, Duprez DA. N-Terminal Pro-B-type Natriuretic Peptide Predicts Mortality in Patients with Left Ventricular Hypertrophy. Int J Cardiol. 2010;143:349-352.
• Baker J, Harrison Q, Huppler Hullsiek K, Tracy R, Duprez D, Henry K, Neaton JD. Interleukin-6 and D-dimer levels are associated with vascular dysfunction in patients with untreated HIV-infection. HIV Medicine 2010;11:608-609.
• Duprez DA. Is Vascular Stiffness a Target for Therapy? Cardiovasc Drugs and Therapy 2010; 24:305-310.
• Duprez D. Coronary Artery Calcification, an Improvement in Risk Classification, Need for Re-Appraisal. J Am Coll Cardiol. 2010;56:1415-1417.
• Baker J, Duprez D. Biomarkers and Associated Cardiovascular Disease. Curr Opinion in HIV and AIDS 2010;5:511-516.
• Brumback LC, Jacobs Jr DR, Dermonda N, Chenc H, Duprez DA. Reproducibility of Arterial Elasticity Parameters Derived from the Radial Artery Diastolic Pulse Contour Analysis: The Multi-Ethnic Study of Atherosclerosis.Blood Press Monit. 2010;15;312-315.
• Lifson AR, Belloso WH, Davey RT, Duprez D, Gatell JM, Hoy JF, Krum EA, Nelson R, Pedersen C, Perez G, Price RW, Prineas RJ, Rhame F, Sampson JH, Worley J. Development of Diagnostic Criteria for Serious Non-Aids Events in HIV Clinical Trials.The Insight Study Group. HIV Clinical Trials 2010;11:205-219.