Professor of Medicine and Biomedical Engineering
Director, NIH Funded Laboratory of Cardiac Energetics and Laboratory of Cellular Therapy for Cardiac Failure, Division of Cardiology
Medical School
Shanghai Medical University, Shanghai, PRC
Ph.D.
Master of Science, School of Engineering, Tufts University, Medford, Massachusetts;
Biomedical Engineering, Institute of Technology Graduate School, University of Minnesota, Minneapolis, Minnesota
Post-doctoral
Cardiology, University of Minnesota, Minneapolis, Minnesota
Research Interests
Myocardial energetics in heart with LV remodeling and congestive heart failure.
I received an Established Investigator Award from American Heart Association (AHA) and First Award from National Institutes of Health (NIH). Currently, I am principal investigator (PI) of three RO1 grants from NIH, and Co-PI of four RO1 grants. Over the years, our research lab has trained 30 trainees (PhD, Post-Doc, residents, and cardiology fellows) and I am currently advisor to four students earning their PhD in Biomedical Engineering.
Professional Organizations
American Physiological Society, American Heart Association, Society of Magnetic Resonance in Medicine, American Physiological Society. Reviewer on NIH SCCOR grant review panel, Special Review Committee (for PPG), and other study sections; Ad Hoc Scientific Journal Reviewer for Circulation, American Journal of Physiology and Diabetes.
Publications
Jameel MN, Wang X, Eijgelshoven MH, Mansoor A, Zhang J. Transmural distribution of metabolic abnormalities and glycolytic activity during dobutamine-induced demand ischemia. Am J Physiol Heart Circ Physiol. 2008, Jun;294(6):H2680-6.
Wu F, Zhang EY, Zhang J, Bache RJ, Beard DA. Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischemic hearts. J Physiol. 2008 Sep 1;586 (Pt 17):4193-208.
Zhang G, Hu Q, Braunlin EA, Suggs LJ, Zhang J. Enhancing efficacy of stem cell transplantation to the heart with a PEGylated fibrin biomatrix. Tissue Eng Part A. 2008 May 14.
Feygin J, Hu Q, Swingen C, Zhang J. Relationships between regional myocardial wall stress and bioenergetics in hearts with left ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2008 May, 294(5):H2313-21.
McFalls EO, Kelly RF, Hu Q, Mansoor A, Lee J, Kuskowski M, Sikora J, Ward HB, Zhang J. The energetic state within hibernating myocardium is normal during dobutamine despite inhibition of ATP-dependent potassium channel opening with glibenclamide. Am J Physiol Heart Circ Physiol. 2007, Nov;293(5):H2945-51.
Feygin J, Mansoor A, Eckman P, Swingen C, Zhang J. Functional and bioenergetic modulations in the infarct border zone following autologous mesenchymal stem cell transplantation. Am J Physiol Heart Circ Physiol. 2007, 293(3):H1772-80.
Zeng L, Hu Q, Wang X, Mansoor A, Lee J, Feygin J, Amhashilkar A, Deans R, Verfaillie C, Zhang J. Bioenergetic and functional consequences of transplantation multipotent progenitor cells in hearts with post-infarction LV remodeling. Circulation. 2007 Apr 10;115(14):1866-75. Epub 2007 Mar 26.
PelachoB, Nakamura Y, Zhang J, Ross J, Heremans Y, Nelson-Holte M, Brad Lemke B, Hagenbrock J, Jiang J, Luttun A, Verfaillie C. Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction. Journal of Tissue Engineering and Regenerative Medicine (in press, 2007).
Tolar J, Wang X, Nakamura Y, Zhang J, Blazer BR. Cardiomyoplasty with multipotent adult progenitor cells after ischemic injury in immunocompetent and immunodeficient mice. Exp Hematol. 2007 Apr;35(4):682-90.
Nakamura Y, Wang X, Xu C, Yoshiyama M, Zhang J. Swine bone marrow-derived mesenchymal stem cells in immuno-deficient mice with induced-acute myocardial infarction (AMI). Stem Cells. 2007 Mar;25(3):612-20.
Zhang G, Nakamura Y, Wang X, Hu Q, Suggs L, Zhang J. Controlled release of stromal cell derived. Factor-1α in situ increases stem cell homing to the infarcted heart. Tissue Eng. 2007 Feb 22; [Epub ahead of print].
Hu Q, Wang X, Lee J, Mansoor A, Wang Z, From AH, Bache, RJ, Zhang J. Profound bioenergetic abnormalities in peri-infarct myocardial regions. Am J Physiol Heart Circ Physiol; 2007, 291(2):H648-57.
Zeng L, Rahrmann E, Hu Q, Zhang J, Verfaillie C. Multi-potent adult progenitor cells from swine bone marrow. Stem Cells. 2006 Nov;24(11):2355-66. Epub 2006 Aug 24.
Lee J, Hu Q, Nakamura Y, Wang Z, Chen W, QL Yong, Zhang J . Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 Tesla.? JMRI 2006 (in press).
Ochiai K, Hu Q, Lee J, Mansoor A, Liu J, Wang X, Gong G, Murakami Y, Ishibashi Y, Shimada T,? Zhang J . Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling. Journal of Cardiovascular Pharmacology 2006; 47 (5): 686-694.
Wang X, Hu Q, Nakamura Y, Lee J, Zhang G, From AH, Zhang J . The role of Sca-1+/CD31-cardiac progenitor cell population in postinfarction LV remodeling. stem cells. 2006; 24:1779-1788.
Wang X, Hu Q, Mansoor A, Lee J, Wang Z, Lee T, From AH, Zhang J . Bioenergetic and functional consequences of stem cell-based VEGF delivery in pressure-overloaded swine hearts. Am J Physiol Heart Circ Physiol. 2006 Apr; 290(4):H1393-405.
Hu Q, Wang X, Lee J, Mansoor A, Wang Z, From AH, Bache, RJ, Zhang J .? Profound bioenergetic abnormalities in peri-infarct myocardial regions. Am J Physiol Heart Circ Physiol (March 31, 2006). doi:10.1152/ajpheart.01387.2005.
Wang X, Hu Q, Mansoor A, Lee J, Wang Z, Xu C, Liu J, Lee T, Arthur From, Zhang J . Bioenergetic and functional consequences of transplanting VEGF overexpressing mesenchymal stem cells into LVH hearts. Am J Physiol Heart Circ Physiol. 2006 (in press).
Zhang G, Xiaohong W, Zongli W, Zhang J , Suggs L. A PEGylated fibrin patch for mesenchymal stem cell.? Tissue Engineering Tissue Eng. 2006 Jan;12(1):9-19.
Portman MA, Zhang J . Myocardial energy transport and heart failure.? Current Cardiology Reviews, 2005;1(1):17-27.
Zhang J , Gong G, Ye Y, Guo T, Mansoor A, Hu Q, Ochiai K, Liu J, Wang X, Cheng Y, Iverson N, Lee J, From AHL, Ugurbil K, Bache, R.? Nitric oxide regulation of myocardial O2 consumption and HEP metabolism. Am J Physiol Heart Circ Physiol;2005;288:H310-H316.
Liu J, Hu Q, Wang ZL, Xu C, Gong G, Mansoor A, Hou M, Zeng L, Zhang JR , Jerosch-Herold M, Guo T, Bache RJ, Zhang J. Autologous stem cell therapy in myocardial infarcts. Am J Physiol;2004 287:H501-511.
Zhang J , Narula J.? Molecular biology of myocardial recovery.? Surg Clin N Am 2004;84:223-242.
Gourine A, Hu Q, Sander P, Kuzmin A, Hanafy N, Davydova S, Zaretsky D, Zhang J .? Interstitial purine metabolites in hearts with LV remodeling.? Am J Physiol 2004;286:H677-H684.
Zhang J , Ugurbil K, From AHL, Bache RJ.? Myocardial oxygenation and high energy phosphate levels during KATP channel blockade.? Am J Physiol Heart Circ Physiol 2003;285:H1420-H1427.
Gong G, Liu J, Liang P, Guo T, Hu Q, Ochiai K, Hou M, Ye Y, Wu X, Mansoor A, From AHL, Ugurbil K, Bache RJ, Zhang J . Oxidative capacity in failing hearts.? Am J Physiol 2003 285(2):H541-8.
Murakami Y, Wu X, Zhang J , Ochiai K, Bache R, Shimada T.? Nicorandil improves myocardial high-energy phosphates in postinfarction porcine hearts. Clin Exp Pharm Phys 2002;29:639-645.
Park SJ, Zhang J , Ye Y, Ormaza S, Liang P, Bank AJ, Miller LW, Bache RJ.? Myocardial creatine kinase expression after left ventricular assist device support.? J Am Coll Card 2002;39:1773-1779.
