Jay Zhang, MD, PhD

Professor of Medicine and Biomedical Engineering

Director, NIH Funded Laboratory of Myocardial Energetics and Laboratory of Cellular Therapy for Cardiac Failure, Division of Cardiology

Medical School

Shanghai Medical University, Shanghai, PRC

Ph.D.

Master of Science, School of Engineering, Tufts University, Medford, Massachusetts;
Biomedical Engineering, Institute of Technology Graduate School, University of Minnesota, Minneapolis, Minnesota

Post-doctoral

Cardiology, University of Minnesota, Minneapolis, Minnesota

Research Interests

Dr. Zhang’s research interests include myocardial energetics in congestive heart failure with left-ventricular remodeling, and stem cells for myocardial repair.

Please click here to view Dr. Zhang's laboratory website:
http://www.med.umn.edu/lhi/research/JZhang_lab/home.html

Dr. Zhang is the recipient of an Established Investigator Award from the American Heart Association (EIA, AHA, 1996) and a First Award from the National Institutes of Health (FIRST, NIH, 1993). Currently, he is the principal investigator of three RO1 grants from the NIH, and the co-PI for two program-project grants.

NIH Study-Section Services

MIM Chartered Member, 2008-2012
Ad Hoc on other NIH study sections (1998-): CVA, BIB, PPG, SCCOR, R24, KO8, and nanotechnology

Journals (Editing and Review)

American Journal of Physiology: Heart and Circulatory Physiology, editorial board (2011-)
Circulation Research, editorial board (2009-present)
Current Cardiology Reviews, Editor-in-Chief (2008-present)
Journal of Cardiovascular Translational Research, editorial board (2010-present)

Biochemistry, reviewer
Biomaterials, reviewer
Circulation, reviewer
Diabetes, reviewer
Journal of the American College of Cardiology, reviewer
PLoS ONE, reviewer
Stem Cells, reviewer

Professional Organizations

American Heart Association, Fellow (1995-present)
American Physiological Society, Fellow (1995-present)
International Society of Heart Research
Society of Magnetic Resonance in Medicine

Publications

Xiong Q, Du F, Zhang P, Chen W, Zhang J. ATP production rate via creatine kinase or ATP synthase in vivo: A novel superfast magnetization saturation transfer method. Circ Res 2011; Feb 3 (e-pub ahead of print)

Xiong Q, Hill, K, Li Q, Suntharalingam P, Mansoor A, Jameel MN, Wang X, Zhang J. A fibrin patch-based enhanced delivery of human embryonic stem-cell-derived vascular cell transplantation in a porcine model of postinfarction left-ventricular remodeling. Stem Cells 2010;Dec 23 (e-pub ahead of print)

Jameel MN, Li Q, Mansoor A, Qiang X, Sarver A, Wang X, Swingen C , Zhang J. Long-term functional improvement and gene-expression changes after bone-marrow-derived multipotent progenitor cell transplantation in myocardial infarction. Am J Physiol Heart Circ Physiol 2010;298:H1348-H1356

Wang X, Jameel MN, Li Q, Mansoor A, Xiong Q, Swingen C, Panetta C, Zhang J. Stem cells for myocardial repair with use of a transarterial catheter. Circulation 2009;120:S238-S246

Wu F, Zhang J, Beard DA. Experimentally-observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism. Proc Natl Acad Sci USA 2009;106:7143-7148

Wu F, Zhang EY, Zhang J, Bache RJ, Beard DA. Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischemic hearts. J Physiol 2008;586:4193-4208

Zhang G, Nakamura Y, Wang X, Hu Q, Suggs L, Zhang J. Controlled release of stromal-cell-derived, factor-1 alpha in situ increases c-kit+ cell homing to the infarcted heart. Tissue Eng 2007;13:2063-2071

Zeng L, Hu Q, Wang X, Mansoor A, Lee J, Feygin J, Amhashilkar A, Deans R, Verfaillie C, Zhang J. Bioenergetic and functional consequences of transplantation multipotent progenitor cells in hearts with post-infarction LV remodeling. Circulation 2007;115:1866-1875

Wang X, Hu Q, Nakamura Y, Lee J, Zhang G, From AH, Zhang J. The role of Sca-1+/CD31-cardiac progenitor cell population in postinfarction LV remodeling. Stem Cells 2006; 24:1779-1788

Murakami Y, Zhang Y, Cho YK, Mansoor AM, Chung JK, Chu C, Francis G, Ugurbil K, Bache RJ, From AHL, Jerosch-Herold M, Wilke N, Zhang J. Myocardial oxygenation during high work states in hearts with postinfarction remodeling. Circulation 1999;99:942-948

Zhang J, Toher C, Erhard M, Zhang Y, Ugurbil K, Bache RJ, Lange T, Homans DC. Relationships between myocardial bioenergetic and left-ventricular function in hearts with volume-overload hypertrophy. Circulation 1997;96:334-343

Zhang J, Wilke N, Wang Y, Zhang Y, Wang C, Eijgelshoven MHJ, Cho YK, Murakami Y, Ugurbil K, Bache RJ, From AHL. Functional and bioenergetic consequences of postinfarction left- ventricular remodeling in a new porcine model: An MRI and 31P MRS study. Circulation 1996; 94:1089-1099

Zhang J, McDonald K. Bioenergetic consequence of left-ventricular remodeling. Circulation 1995;92:1011-1019 http://circ.ahajournals.org/cgi/content/full/92/4/1011

McDonald K, Yoshiyama M, Francis GS, Ugurbil K, Cohn J, Zhang J. Abnormal myocardial bioenergetics in a canine model of left-ventricular dysfunction. JACC 1994;23:786-793

Zhang J, Merkle H, From AHL, Ugurbil K, Bache RJ. Bioenergetic abnormalities associated with severe left-ventricular hypertrophy. J Clin Invest 1993;92:993-1003