Nacide Ercan-Fang

Staff Physician, VAMC and Assistant Professor of Medicine, University of Minnesota

Research Interests and areas of potential collaboration:

Carbohydrate metabolism in general and Glycogen Metabolism in the liver specifically.

Projects Underway:

1) Uric acid may regulate glycogenolysis in the liver: Career developement grant, studying effect of uric acid on phosphorylase regulation

2) Effects of indole derivative compounds on phosphorylase is a colloborative project with Pfizer, Inc

3) Identification of the caffeine binding site in liver glycogen phosphorylase. A new project submitted.

Selected publications:

1. Ercan, N., Nuttall, F.Q., and Gannon, M.C.: Incorporation Of Glycogenin Into Hepatic Glycogen After Oral Glucose Administration.  J Biol Chem , 269:22328-22333, 1994.

2. Ercan, N., Gannon, M.C. and Nuttall, F.Q.:  Interrelationships Between Liver Glycogen Synthase, Phosphorylase and the Glycogen Concentration in Rats Given a Single Glucose Load Orally.  A 24 Hour Study.  Arch Biochem Biophys,  315(1):35-40, 1994.

3. Ercan, N., Nuttall, F.Q. and Gannon, M.C.: Effects of Glucagon With or Without Insulin Administration on Liver Glycogen Metabolism.  Am J Physiol, 269:E231-E238, 1995.

4. Ercan, Nacide and Nuttall, Frank Q.:  Allosteric Regulation of Liver Phosphorylase a:  Revisited Under Approximated Physiological Conditions. Arch Biochem Biophys, 328(2):255-264, 1996.

5. Ercan-Fang, N. and Nuttall, F.Q.: The Effect of Caffeine and Caffeine Analogs on Rat Liver Phosphorylase a Activity. J  Pharmacol Exper Therap, 280 (3):1312-1318, 1997.

6. Gannon, M.C., Nuttall, F.Q., Grant, C.T., Ercan-Fang, S., Ercan-Fang, N.: Stimulation of Insulin   Secretion By Fructose Ingested With Protein in People With Untreated NIDDM. Diab Care, 21:16-22, 1998

7. Gannon, M.C., Nuttall, F.Q., Westphal, S., Fang, S., Ercan-Fang, N.:  The Metabolic Response of High-Carbohydrate, High-Starch Meals Compared With Moderate-Carbohydrate, Low-Starch Meals in Subjects with Type 2 Diabetes.  Diab Care, 21:1619-1626, 1998

8. Ercan-Fang, N. , Nuttall, F.Q and Gannon, M.C.:  Uric Acid  Inhibits Liver Phosphorylase a Activity  Under Simulated In-vivo Conditions.   Am J  Physiol Endocrinol Metab 280:E248-E253, 2001