Nacide Ercan-Fang
Staff Physician, VAMC and Assistant Professor of Medicine, University of Minnesota
Research Interests and areas of potential collaboration:
Carbohydrate metabolism in general and Glycogen Metabolism in the liver specifically.
Projects Underway:
1) Uric acid may regulate glycogenolysis in the liver: Career developement grant, studying effect of uric acid on phosphorylase regulation
2) Effects of indole derivative compounds on phosphorylase is a colloborative project with Pfizer, Inc
3) Identification of the caffeine binding site in liver glycogen phosphorylase. A new project submitted.
Selected publications:
1. Ercan, N., Nuttall, F.Q., and Gannon, M.C.: Incorporation Of Glycogenin Into Hepatic Glycogen After Oral Glucose Administration. J Biol Chem , 269:22328-22333, 1994.
2. Ercan, N., Gannon, M.C. and Nuttall, F.Q.: Interrelationships Between Liver Glycogen Synthase, Phosphorylase and the Glycogen Concentration in Rats Given a Single Glucose Load Orally. A 24 Hour Study. Arch Biochem Biophys, 315(1):35-40, 1994.
3. Ercan, N., Nuttall, F.Q. and Gannon, M.C.: Effects of Glucagon With or Without Insulin Administration on Liver Glycogen Metabolism. Am J Physiol, 269:E231-E238, 1995.
4. Ercan, Nacide and Nuttall, Frank Q.: Allosteric Regulation of Liver Phosphorylase a: Revisited Under Approximated Physiological Conditions. Arch Biochem Biophys, 328(2):255-264, 1996.
5. Ercan-Fang, N. and Nuttall, F.Q.: The Effect of Caffeine and Caffeine Analogs on Rat Liver Phosphorylase a Activity. J Pharmacol Exper Therap, 280 (3):1312-1318, 1997.
6. Gannon, M.C., Nuttall, F.Q., Grant, C.T., Ercan-Fang, S., Ercan-Fang, N.: Stimulation of Insulin Secretion By Fructose Ingested With Protein in People With Untreated NIDDM. Diab Care, 21:16-22, 1998
7. Gannon, M.C., Nuttall, F.Q., Westphal, S., Fang, S., Ercan-Fang, N.: The Metabolic Response of High-Carbohydrate, High-Starch Meals Compared With Moderate-Carbohydrate, Low-Starch Meals in Subjects with Type 2 Diabetes. Diab Care, 21:1619-1626, 1998
8. Ercan-Fang, N. , Nuttall, F.Q and Gannon, M.C.: Uric Acid Inhibits Liver Phosphorylase a Activity Under Simulated In-vivo Conditions. Am J Physiol Endocrinol Metab 280:E248-E253, 2001
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