Michael Georgieff, M.D.

http://www.med.umn.edu/peds/neonat/directory/gregorieff/home.html
http://www.umn.edu/cnbd

Current Positions:
  Professor, Department of Pediatrics University of Minnesota School of Medicine, Minneapolis, Minnesota
  Professor, Institute of Child Development, University of Minnesota, College of Education, Minneapolis, Minnesota
  Co-Director and Founder, Center for Neurobehavioral Development University of Minnesota Minneapolis, Minnesota

Curriculum Vitae (pdf) 

Research Interests:
My research focuses on two areas of fetal/neonatal nutrition:

 1) the effect of fetal/neonatal iron nutrition on brain development and neurocognitive function; and

 2) the effect of illness on neonatal protein-energy metabolism.
 

Publications:

1. Georgieff MK, Petry CE, Wobken JD, Oyer CE. Liver and brain iron deficiency in newborn infants with bilateral renal agenesis (PotterÕs syndrome). Pediatr Pathol 16:509-519, 1996.

 2. Georgieff MK, Mills MM, Gomez-Martin O, Sinaiko AR. Blood pressure in premature and full-term infants from birth to four months. Pediatr Nephrol 10:152-155, 1996.

 3. deRegnier RA, Guilbert T, Mills MM, Georgieff MK. Early body composition changes and growth failure in premature infants with bronchopulmonary dysplasia. J Nutr 126:168-175, 1996.

 4. Peters C, Georgieff MK, deAlacron P, Widness JA. Effect of chronic erythropoietin administration on plasma iron in newborn lambs. Biol Neonate 70:218-228, 1996.

 5. deRegnier RA, Georgieff MK, Nelson CA. Cognitive event-related brain potentials in four-month-old infants at risk for neurodevelopmental impairments. Dev Psychobio 30:11-28, 1997.

 6. Smith KM, Wahlig TM, Bing DR, Georgieff MK, Boros SJ, Mammel MC. Lower respiratory rates without decreases in oxygen consumption during neonatal synchronized intermittent mandatory ventilation. Intensive Care Medicine 23:463-468, 1997.

 7. Georgieff MK, Petry CD, Mills MM, McKay H, Wobken JD. Increased N-glycosylation and reduced transferrin binding capacity of transferrin receptor isolated from placentas of diabetic mothers. Placenta 18:563-568, 1997.

 8. Guiang SF III, Georgieff MK, Schmidt RL, Lambert DJ, Widness JA. Intravenous iron supplementation effect on tissue iron and hemoproteins in chronically phlebotomized lambs. Am J Physiol 273:R2124-2131, 1997.

 9. Georgieff MK, Work Group on Breastfeeding of the American Academy of Pediatrics. Breastfeeding and the use of human milk. Pediatrics 100: 1035-1039, 1997.

 10. Lindeke LL, Mills MM, Georgieff MK, Tanner ME, Wrbsky PM. Health, growth and use of community services in NICU graduates at early school age. J Pediatr Health Care 12:299-304, 1998.

 11. Georgieff MK. Intrauterine growth and neurodevelopment. J Pediatr 133:3-5. 1998.

 12. Guiang SF III, Eaton MA, Merchant JL, Flanagan KB, Gordon KL, Georgieff MK. Intracardiac iron redistribution in newborn guinea pigs following isolated and combined fetal hypoxemia and fetal iron deficiency. Can J Physiol Pharm 76:930-936, 1999.

 13. Rao R, Sullivan D, Wu P, Wobken JD, Nelson CA, Georgieff MK. Perinatal brain iron deficiency increases the vulnerability of rat hippocampus to hypoxic-ischemic insult. J Nutr 129:199-206, 1999.

 14. Georgieff MK, Liebold EA, Wobken JD, Berry SA. Increased placental iron-regulatory protein-1 expression in diabetic pregnancies complicated by fetal iron deficiency. Placenta 20:87-93, 1999.

 15. Luciana M, Lindeke L, Georgieff MK, Mills MM, Nelson CA. Neurobehavioral evidence for working memory deficits in school-aged children with histories of neonatal intensive care treatment. Dev Med Child Neurol. 41:521-533, 1999.

 16. Georgieff MK. Committee on Nutrition of the American Academy of Pediatrics. Iron Fortification of Infant Formulas. Pediatrics 104:119-123, 1999.

 17. DeHaan M, Georgieff MK, Nelson CA, Bauer P. Memory for event sequences in low-risk toddlers born between 27-42 weeks of gestation. Dev Med Child Neurol 42:304-312, 2000.

 18. Mrozek J, Georgieff MK, Blazar B, Mammel MC, Schwarzenberg SJ. Neonatal sepsis: Effect on protein and energy metabolism. J Perinatol 20:96-100, 2000.

 19. de Ungria M, Rao R, Wobken JD, Luciana M, Nelson CA, Georgieff MK. Perinatal iron deficiency decreases cytochrome c oxidase activity in selective regions of neonatal rat brain. Pediatr Res 48:169-176, 2000.

 20. Nelson CA, Wewerka S, Thomas K, Tribby-Walbridge S, deRegnier RA, Georgieff MK. Neurocognitive sequelae of infants of diabetic mothers. Behav Neurosci 114:950-956, 2000.

 21. deRegnier RA, Nelson CA, Thomas K, Wewerka S, Georgieff MK. Neurophysiologic evaluation of auditory recognition memory in healthy newborn infants and infants of diabetic mothers. J Pediatr 137:777-784, 2000.

 22. Georgieff MK, Wobken JK, Welle J, Burdo JR, Connor JR. Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta. Placenta 21:799-804, 2000.

 23. Rao R and Georgieff MK. Perinatal iron metabolism. Recent Res Devel Nutr 3:97-114, 2000.

 24. Georgieff MK. Fetal and neonatal iron metabolism. Sem Neonat Nutr Metab 7:1-5, 2000.

 25. Mulrooney DA, Carpenter B, Georgieff MK, Angel C, Hunter D, Foker J, Steiner M. Hepatic mesenchymal hamartoma in a neonate. Am J Pediatr Hem/Onc (in press).

 26. Rao R, Georgieff MK. Neonatal iron nutrition. Sem Neonatol (in press).

 Current Book Chapters

 1. Georgieff MK. Therapy of infants of diabetic mothers. In Burg FD, Ingelfinger JR, Wald ER, Polin RA, Eds. Current Pediatric Therapy 15. Philadelphia: W.B. Saunders, 1995; 793-803.

 2. Wahlig TM, Georgieff MK. The effect of neonatal illness on nutritional requirements. In Pereira GR, Georgieff MK, Eds. Clinics in Perinatology. Philadelphia: W.B. Saunders, 1995; 22:77-96.

 3. Guiang SF III, Georgieff MK. Fetal and Neonatal Iron Metabolism. In Fox WW, Polin RA, Eds. Fetal and Neonatal Physiology. Philadelphia: W.B. Saunders, 1997 (second edition).

 4. Georgieff MK, Pereira GR. Nutritional Assessment. In Fox WW, Polin RA, Eds. Fetal and Neonatal Physiology. Philadelphia: W.B. Saunders, 1997 (second edition).

 5. Georgieff MK. Nutrition. In Avery GB, MacDonald M, Fletcher MA, Eds. Neonatology: Pathophysiology and Management of the Newborn (fifth edition). Philadelphia: Lippincott & Co, 1998.

 6. Premer D, Georgieff MK. Nutritional Needs of Ill Neonates. Neo Reviews, American Academy of Pediatrics, Elk Grove Village. 1999.

 7. Rao R, Georgieff MK. Early Nutrition and Brain Development. Minnesota Symposium on Child Psychology, vol. 31. New Jersey: Erlbaum Assoc, 2000; pp 1-30.

 8. Georgieff MK. Prematurity and Early Brain Development. In Early Experience and Childhood Development. National Academy of Sciences Position Statement. Washington, D.C.: National Academy of Sciences, 2000.

 9. Georgieff MK, Rao R. The Role of Nutrition in Cognitive Development. In Handbook of Cognitive Neuroscience. Cambridge, MA: MIT Press (in press).

 10. Georgieff MK. Hematologic Disorders in the Neonate: Iron Deficiency. In Polin RA, Spitzer AR, Eds. Fetal and Neonatal Secrets. Philadelphia: Hanley & Belfus, Inc. (in press).

 Books (editor)

 1. Pereira GR, Georgieff MK. Neonatal/Perinatal Nutrition. Clinics in Perinatology. Volume 22:1. Philadelphia: W.B. Saunders, 1995.

 2. Pediatric Nutrition Handbook. American Academy of Pediatrics, 1997.

 Manuscripts Submitted or in Preparation

 1. Siddappa AJM, Wobken JD, Rao R, Leibold EA, Georgieff MK. Ontogeny of iron regulatory protein (IRP) expression in the developing rat brain.

 2. Siddappa AJM, Wobken JD, Leibold EA, Rao R, Connor JR, Georgieff MK. Localization and expression of transferrin receptor (TfR), divalent metal transporter-1 (DMT-1) and iron regulatory proteins (IRPs) in iron-deficient perinatal rat brain.

 3. Rao R, Tkac I, Siddappa AJ, Wewerka S, Gruetter R, Georgieff MK. Perinatal brain iron deficiency alters the hippocampal metabolic profile in developing rats.

 4. Rao R, Tkac I, Siddappa AJ, Gruetter R, Georgieff MK. In vivo evaluation of the developmental profile of the metabolites in the hippocampus, striatum and cerebral cortex in rats by proton NMR spectroscopy at 9.4 Tesla.

 RECENT ABSTRACTS: (* denotes presentation)

 1.* Rao R, Wessendorf M, Wobken JA, Sullivan D, Wu M, Georgieff MK. Effect of perinatal iron deficiency on hippocampal cytochrome oxidase activity in a hypoxic-ischemic encephalopathy model. J Invest Med 44(7):344A, 1996. Chicago, Illinois.

 2.* Johnson DE, Albers LH, Iverson S, Mathers M, Dole K, Georgieff MK, Hostetter MK, Miller LC. Health status of Eastern European (EE) orphans referred for adoption. Pediatr Res 39:134A, 1996. Presented at the annual meeting of the Society for Pediatric Research.

 3.* Johnson DE, Albers LH, Iverson S, Mathers M, Dole K, Georgieff MK, Hostetter MK, Miller LC. Health status of US adopted eastern European (EE) orphans. Pediatr Res 37:134A, 1996. Presented at the annual meeting of the Society for Pediatric Research.

 4.* Georgieff MK, Widness JA, Schmidt RL, Lambert DJ, Guiang III S. Tissue iron in phlebotomized lambs treated with and without iv iron. Pediatr Res 37:309A, 1996. Presented at the annual meeting of the Society for Pediatric Research.

 5.* Georgieff MK, Seybold V, Mills MM, McKay H, Wobken JA. Increased molecular weight of transferrin receptor isolated from placentas of diabetic mothers. Pediatr Res 37:310A, 1996. Presented at the annual meeting of the Society for Pediatric Research.

 6.* Georgieff MK, Liebold EA, Wobken JA, Berry SA. Increased placental iron-responsive protein-1 (IRP-1) and transferrin receptor (TfR) mRNA in diabetic pregnancies complicated by fetal iron deficiency. Pediatr Res 41:44A, 1997. Presented at the annual meeting of the Society for Pediatric Research.

 7.* Luciana M, Lindeke LL, Mills MM, Nelson CA, Georgieff MK. Use of the Cambridge neuropsychological testing automated battery (CANTAB) to assess frontostriatal circuit deficits in nicu graduates. Pediatr Res 41:203A, 1997. Presented at the annual meeting of the Society for Pediatric Research.

 8.* Mrozek JD, Georgieff MK, Blazar BR, Mammel, MC, Schwarzenberg SJ. Neonatal sepsis: effect on protein and energy metabolism. Pediatr Res 41:237A, 1997. Presented at the annual meeting of the Society for Pediatric Research.

 9.* Rao R, Wobken JD, Sullivan D, Wu P, Georgieff MK. Perinatal brain iron deficiency increases the vulnerability of rat hippocampus to hypoxic ischemic insult. Pediatr Res 41:239A, 1997. Presented at the annual meeting of the Society for Pediatric Research.

 10.* de Ungria M, Rao R, Luciana M, Georgieff MK. Perinatal iron deficiency decreases cytochrome oxidase (CytOx) activity in specific regions of neonatal rat brain. Pediatr Res 41:289A, 1997. Presented at the annual meeting of the Society for Pediatric Research.

 11.* de Regnier RA, Nelson CA, Thomas K, Wewerka S, Tribby-Walbridge S, Georgieff MK. Auditory brain maturation and recognition memory in newborn infants of diabetic mothers. Pediatr Res 43:212A, 1998. Presented at the annual meeting of the Society for Pediatric Research.

 12.* Nelson CA, de Regnier RA, Wewerka S, Tribby-Walbridge S, Georgieff MK. Electrophysiological assessment of recognition memory in 6-month-old infants of diabetic mothers and growth retarded infants. Pediatr Res 43:223A, 1998. Presented at the annual meeting of the Society for Pediatric Research.

 13.* Rao R, de Ungria M, Wobken JD, Wu P, Georgieff MK. Perinatal brain iron deficiency predisposes the rat hippocampus to long-term damage following hypoxic-ischemic insult. Pediatr Res 43:267A, 1998. Presented at the annual meeting of the Society for Pediatric Research.

 14.* Georgieff MK, Wewerka S, Tribby-Walbridge S, de Regnier RA. Follow-up iron status of infants of diabetic mothers (IDM) and intrauterine growth retarded (IUGR) infants with abnormally low neonatal serum ferritin concentrations. Pediatr Res 45:111A, 1999. Presented at the annual meeting of the Society for Pediatric Research.

 15.* Johnson DE, Aronson JE, Federici R, Faber S, Tartaglia M, Daunauer L, Windsor M, Georgieff MK. Profound global growth failure afflicts residents of pediatric neuropsychiaric institutes in Romania. Pediatr Res 45:1279A, 1999. Presented at the annual meeting of the Society for Pediatric Research.

 16.* de Ungria M, Rao R, Luciana M, Wobken JK, Nelson CA, Georgieff MK. Regional loss of cytochrome oxidase (CytOx) activity occurs in neonatal rat brain following perinatal iron deficiency. Pediatr Res 45:280A, 1999. Presented at the annual meeting of the Society for Pediatric Research.

 17.* Georgieff MK, Wobken JD, Tran QH, Leibold EE. Transferrin receptor (TfR) and HFE protein characterization, localization and quantitation in placentas of iron deficient intrauterine growth retarded (IUGR) newborns. Pediatr Res 45:283A, 1999. Presented at the annual meeting of the Society for Pediatric Research.

 18.* Guiang III S, Sipple DP, Georgieff MK. Chronic neonatal hypoxia increases cardiac myoglobin and is associated with preservation of in vitro myocardial contractility in iron deficient guinea pigs. Pediatr Res 45:283A, 1999. Presented at the annual meeting of the Society for Pediatric Research.

 19.* Rao R, de Ungria M, Luciana M, Nelson CA, Georgieff MK. Effect of perinatal brain iron deficiency on cytochrome oxidase activity of cognitive and noncognitive structures of the brain following a hypoxic-ischemic injury in neonatal rats. Pediatr Res 45:289A, 1999. Presented at the annual meeting of the Society for Pediatric Research.

 20.* Rao R, de Ungria M, Tkac I, Pfeuffer J, Greutter R, Nelson CA, Georgieff MK. In vitro 1H nuclear magnetic resonance spectroscopy (MRS) with a 9.4T magnet for evaluation of hippocampal metabolism in the developing rat brain. Pediatr Res 45:346A, 1999. Presented at the annual meeting of the Society for Pediatric Research.

 21.* Tkac I, Rao R, de Ungria M, Pfeuffer J, Georgieff MK, Gruetter R. In vivo 1H NMR spectroscopy of the developing rat hippocampus. Platform Presentation at the Annual Meeting of the American Pediatric Society/Society for Pediatric Research, May 4, 1999, San Francisco, California.

 22.* Georgieff MK, Wobken JD, Tran QH, Leibold EE. Transferrin receptor (TfR) and HFE protein characterization, localization and quantitation in placentas of iron deficient intrauterine growth retarded (IUGR) newborns. Presented at the International BioIron Conference; Sorrento, Italy; May, 1999.

 23.* Georgieff MK, de Ungria M, Rao R, Luciana M, Wobken JK, Nelson CA. Regional loss of cytochrome oxidase (CytOx) activity occurs in neonatal rat brain following perinatal iron deficiency. . Presented at the International BioIron Conference; Sorrento, Italy; May, 1999.

 24.* Georgieff MK, Wobken JK, Burdo JR, Connor JR. Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta. Pediatr Res 47:287A, 2000. Presented at the annual meeting of the Society for Pediatric Research.

 25.* Premer DM, Georgieff MK, Goertz R, Mammel MC, Schwarzenberg SJ. Muscle proteolysis and weight loss in a neonatal rat model of sepsis. Pediatr Res 47:295A, 2000. Presented at the annual meeting of the Society for Pediatric Research.

 26.* Stolarova MP, Whitney HL, Georgieff MK, deRegnier R-AO, Nelson CA. Early recognition memory in healthy premature infants. Pediatr Res 47:325A, 2000. Presented at the annual meeting of the Society for Pediatric Research.

 27.* Premer DM, Robison L, Georgieff MK, Guiang SF III. A trial of ECMO for infants with congenital diaphragmatic hernia: how long is long enough? Pediatr Res 47:427A, 2000. Presented at the annual meeting of the Society for Pediatric Research.

 28.* Siddappa AJM, Wobken JD, Rao R, Leibold EA, Georgieff MK. Ontogeny of iron regulatory protein (IRP) expression in the developing rat brain. Pediatr Res 49:292A, 2001. Presented at the annual meeting of the Society for Pediatric Research.

 29.* Siddappa AJM, Wobken JD, Leibold EA, Rao R, Connor JR, Georgieff MK. Localization and expression of transferrin receptor (TfR), divalent metal transporter-1 (DMT-1) and iron regulatory proteins (IRPs) in iron deficient perinatal rat brain. Pediatr Res 49:292A, 2001. Presented at the annual meeting of the Society for Pediatric Research.

 30.* Siddappa AJM, Wewerka S, Georgieff MK, Nelson CA, deRegnier RA. Auditory recognition memory in newborn infants of diabetic mothers. Pediatr Res 49:349A, 2001. Presented at the annual meeting of the Society for Pediatric Research.

 31.* Rao R, Tkac I, Siddappa AJ, Wewerka S, Gruetter R, Georgieff MK. Perinatal brain iron deficiency alters the hippocampal metabolic profile in developing rats. Pediatr Res 49:435A, 2001. Presented at the annual meeting of the Society for Pediatric Research.

 32.* Rao R, Tkac I, Siddappa AJ, Gruetter R, Georgieff MK. In vivo evaluation of the developmental profile of the metabolites in the hippocampus, striatum and cerebral cortex in rats by proton NMR spectroscopy at 9.4 Tesla. Pediatr Res 49:444A, 2001. Presented at the annual meeting of the Society for Pediatric Research.

 33. Thureen P, Guiang SF III, Melara D, Georgieff MK. Nutritional management in the neonate: results of a current practices survey. Pediatr Res 49:415A, 2001.