Angeliki Georgopoulos, M.D.

Current Position (s): Professor, Department of Medicine, University of Minnesota Medical School
Director, Women's Comprehensive Health Center, Minneapolis VA Medical Center

Research Interests and areas of potential collaboration:
Postprandial triglyceride-rich lipoprotein studies in diabetes.

Selected publications:
 

  PUBLICATIONS PEER-REVIEWED  

 1. Kalu DN, Hadji_Georgopoulos A, Sarr MG, Solomon BA, Foster GV (1974) The role of parathyroid hormone in the maintenance of plasma calcium levels in rats. Endocrinology 95: 1156_65.
Dr Georgopoulos contributed in the planning, execution, analysis and writing of this paper.

 2. Kalu DN, Hadji_Georgopoulos A, Foster GV (1975) Evidence for physiological importance of calcitonin in the regulation of plasma calcium in rats. J Clin Invest 55: 722_27.
Dr Georgopoulos contributed in the planning, execution, analysis and writing of this paper.

 3. Kalu DN, Hadji_Georgopoulos A, Foster GV (1975) Effect of calcium deprivation on parathyroid hormone_mediated bone and kidney contributions to the maintenance of plasma calcium in rats. J Endocrinol 64: 299_304.
Dr Georgopoulos contributed in the planning, execution, analysis and writing of this paper.

 4. Kalu DN, Hadji_Georgopoulos A, Foster GV (1975) A dissociation of the effects of PTH on bone matrix and calcium in rats. Hormone Met Res 7: 443_4.
Dr Georgopoulos contributed in the planning, execution, analysis and writing of this paper.

 5. Kalu DN, Hadji_Georgopoulos A, Foster GV (1975) Acute regulation of plasma calcium by parathyroid hormone in rats: effect of age. In: The Fifth Parathyroid Conference, Oxford, UK, pp. 270_72.
Dr Georgopoulos contributed in the planning, execution, analysis and writing of this paper.

 6. Kalu DN, Hadji_Georgopoulos A, Foster GV (1975) Further studies on the hypercalcemic effect of acute calcitonin deficiency in rats. Endocrinology 98: 534_39.
Dr Georgopoulos contributed in the planning, execution, analysis and writing of this paper.

 7. Schmidt MI, Hadji_Georgopoulos A, Rendell M, Margolis S, Kowarski AA (1979) Hyperglycemia and associated free insulin and cortisol changes in "Somogyi_like" patients during continuous glucose monitoring. Diabetes Care 2: 457_64.
Dr Georgopoulos contributed in the planning, execution, analysis and writing of this paper.

 8. Hadji_Georgopoulos A, Schmidt MI, Margolis S, Kowarski AA (1980) Elevated hypoglycemic index and late hyperinsulinism in symptomatic postprandial hypoglycemia. J Clin Endocrinol Met 50: 371_76.
Dr Georgopoulos led the planning, execution, analysis and writing of this paper.
 
 9. Hadji_Georgopoulos A (1980) Hypoglycemic index. JAMA  244: 2608.

10. Schmidt MI, Hadji_Georgopoulos A, Rendell M, Margolis M, Kowarski AA (1981) The Dawn phenomenon, an early morning blood glucose rise. Implications for diabetic intraday blood glucose variation. Diabetes Care 4: 579_85.
Dr Georgopoulos contributed in the planning, execution, analysis and writing of this paper.

11. Hadji_Georgopoulos A, Broe P, Mehigan P, Kowarski AA, Cameron JL (1982) Endocrine and exocrine function in intrasplenic pancreatic autotransplants. Surgery 91: 210_6.
Dr Georgopoulos led the planning, execution, analysis and writing of this paper.
 
12. Herschopf R, Plotnick L, Kaya K, Benedict GW, Hadji_Georgopoulos A, Margolis S, Kowarski AA (1982) Short_term improvement in glycemic control utilizing continuous subcutaneous insulin infusion: The effect on 24 hour integrated concentrations of counter_regulatory hormone and plasma lipids in insulin_dependent diabetes mellitus. J Clin Endocrinol Met 54: 504_09.
Dr Georgopoulos contributed in the planning, execution, analysis and writing of this paper.

13. Damlouji N, Kaeves_Cohen R, Charache S, Hadji_Georgopoulos A, Folstein M (1982) Social disability and psychiatric morbidity in sickle cell anemia and diabetes. Psychosomatics 23: 9.
Dr Georgopoulos contributed to the planning, execution, analysis and writing of this paper.
 
14. Hadji_Georgopoulos A, Schmidt MI, Elahi D, Herschopf R, Kowarski AA (1983) Increased gastric inhibitory polypeptide levels in patients with symptomatic postprandial hypoglycemia. J Clin Endocrinol Met 56: 648_52.
Dr Georgopoulos led the planning, execution, analysis and writing of this paper.
 
15. Georgopoulos A (1983) CSII and ICT in treating type I diabetic individuals. Diabetes Care 6: 210.

Dr. Georgopoulos participated in the execution of the Coronary Prevention Trial which led to the following three publications.

16. (1983) Preentry characteristics of participants in the lipid research clinics' coronary prevention trial. J Chron Dis 36: 467_79.

17. (1984) The Lipid Research Clinic Coronary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA 251:361_64.

18. (1984) The Lipid Research Clinics Coronary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 251: 365_74.

19. Georgopoulos A, Margolis S, Bachorik P, Kwiterovich P (1988): Effect of improved glycemic control on the response of plasma triglycerides to ingestion of a saturated fat load in normotriglyceridemic and hypertriglyceridemic diabetic subjects.  Metabolism  37: 866-871.

20. Georgopoulos A, Applebaum-Bowden D, Margolis S (1988): Improved glycemic control lowers plasma apoprotein E ang triglyceride levels following ingestion of a fat load in insulin- dependent diabetic subjects.  Metabolism  37: 837-843.

21. Georgopoulos A, Rosengard A (1989): Abnormalities in the metabolism of postprandial and fasting triglyceride-rich lipoprotein subfractions in normal and insulin-dependent diabetic subjects: Effects of sex. Metabolism 38: 781-789.

22. Georgopoulos A, Phair RD (1991): Abnormal clearance of postprandial Sf 100-400 plasma lipoproteins in insulin dependent diabetes mellitus (IDDM). J Lipid Res 32: 1133-1141.

23. Georgopoulos A, Saudek CD (1992): Normalization of the composition of  triglyceride-rich lipoprotein subfractions in insulin dependent diabetic subjects during infusion with a programmable implantable medication system (PIMS). Diabetes Care 15:19-26.

24.  Miller M, Kwiterovich PO Jr, Bachorik PS, Georgopoulos A (1993): Decreased 
postprandial response to a fat meal in normotriglyceridemic men with hypoalphalipoproteinemia. Arteriosclerosis and Thrombosis  13: 385-392.

25. Laube B, Georgopoulos A, Adams GK III (1993): Preliminary study of the efficacy of insulin aerosol delivered by oral inhalation in diabetic subjects. JAMA 269: 2106- 2109.
 
26. Harris EL, Feldman S, Robinson RC, Sherman S, Georgopoulos, A (1993): Racial differences in the relationship between blood pressure and risk of retinopathy among patients with non-insulin dependent (type II) diabetes. Diabetes Care 16:748-754. 
 
27. Georgopoulos, A (1994) Are chylomicron remnants involved in the atherogenesis of insulin-dependent diabetes mellitus? J Lab Clin Med 122: 640-646.
 
28. Georgopoulos A, Saudek CD (1994) Intraperitoneal insulin delivery decreases the levels of  chylomicron remnants in patients with insulin dependent diabetes. Diabetes Care 17: 1295-1299.
 
29. Georgopoulos A, Kafonek SD, Raikhel I (1994): Postprandial triglyceride-rich lipoproteins from type I diabetic subjects increase cholesteryl ester accumulation in THP-1 macrophages. Metabolism 43: 1063-1072.
 
30. Rodriguez A, Kafonek SD, Georgopoulos A, Bachorik PS (1994): Cell density affects foam cell formation in THP-1 macrophages J Lipid Res 35: 1909-1017.
 
  Dr Georgopoulos participated in the multicenter Metformin study group that resulted in  the following publication:
 
31. DeFronzo RA, Goodman AM. Efficacy of metformin in patients with non-insulin -dependent diabetes mellitus. The Multicenter Metformin Study Group. (1995) N Engl J Med 333: 541-9
 
32.  Miller M, Teter B, Dolinar C, Georgopoulos A (1998): Differential effect of the NCEP II  diet on fasting and postprandial plasma triacylglycerol in normocholesterolemic adults.  J Nutrition 128:582-586. 
  
33. Georgopoulos A, Bantle JP, Noutsou M, Swaim WR, Parker SJ (1998): Differences in the metabolism of postprandial lipoproteins after a high monounsaturated fat versus a high carbohydrate diet in patients with type 1 diabetes mellitus.  Arteriosclerosis Thrombosis and Vascular Biology 18 :773-782.
 
34. Georgopoulos A (1999). Postprandial triglyceride metabolism in diabetes mellitus.  Clinical Cardiology 22 (Suppl. II) 28-33.
 
34. Harris EL, Sherman S, Georgopoulos A (1999). Black-white differences in risk of developing retinopathy among persons with type 2 diabetes Diabetes Care 22:779-783.
 
35. Noutsou M Georgopoulos A.  (1999). Effects of Simvastatin on postprandial triglyceride-rich lipoproteins in patients with insulin dependent diabetes mellitus.  (Journal of Diabetes and its Complications13:98-104)
 
36.  Georgopoulos A, Bantle JP, Noutsou M, Hoover H (2000).  Effect of a High Carbohydrate vs a High Monounsaturated Fat Diet on the Atherogenic Potential of Fasting VLDL in patients with Type 1 Diabetes. ( J Nutrition 130: 2503-2507)
 
37. Bantle JP, Raatz SK, Thomas W Georgopoulos A (2000).  Effects of dietary fructose on plasma lipids in healthy subjects.  ( Am J Clin Nutr 72: 1128-1134)
 
38. Georgopoulos A , Aras O, Tsai MY (2000). Codon-54 Polymorphism of the Fatty Acid Binding Protein 2 Gene is associated with elevation of fasting and postprandial triglyceride in Type 2 Diabetes. ( J. Clin. Endocrinol. Met. 85: 3155-3160).
 
 BOOK CHAPTERS AND REVIEWS
 
1. Hadji-Georgopoulos A, Margolis S (1982) Diabetic ketoacidosis: Pitfalls in management. Hospital Medicine, vol. 5
 
 2.  Margolis S, Georgopoulos A (1984) Hypoglycemia. In: The Principles and Practice of Medicine, (Eds) Harvey, Johns, McKusick, Owens, Ross, 21st Edition, pp. 904_14.
 
3. Georgopoulos A (1985) Blood sugar control, hypertriglyceridemia and diabetes. Infusion 4: 4_5. 
 
4. Kwiterovich PO, Bachorik PS, Franklin FA, Margolis S, Georgopoulos A, Teng B, Sniderman AD (1985) Effect of dietary treatment on the plasma levels of lipids, lipoprotein cholesterol and LDL B protein in children with type II hyperlipoproteinemia. In: Current topics in the detection and treatment of lipid and lipoprotein disorders of children, AR Liss: New York, pp. 123-137.
 
5. Georgopoulos A, Margolis S (1986) Postprandial hypoglycemia.  In: Current therapy in gastroenterology and liver disease,  (Ed) T. Bayless.
 
6. Georgopoulos A, Margolis, S. (1988) Hypoglycemia.  In: The Principles ana Practice of Medicine, (Eds) Harvey, Johns, McKusick, Owens, Ross, 22nd Edition, pp 968-976.
 
 7. Margolis S, Georgopoulos A (1996) Hypoglycemia. In: The Principles and Practice of Medicine, 23rd. edition, Stobo et al. (eds.), Lange: Stamford, CT pp 332-337.
 
8. Georgopoulos A (1997) The LDL receptor. In Principles of Medical Biology, Bhittar (ed) JAI Press, Greenwich, CT pp 169-188.
 
 9. Georgopoulos A (1998) Disorders of lipid metabolism. In Endocrine Pathophysiology
 Niewoehner (ed), Fence Creek Publishing Madison,CT, pp 141-157 .
 
  BOOK REVIEW
 
 Hadji_Georgopoulos A (1982) Clinical Diabetes (WB Saunders). Johns Hopkins Med J 151: 188.
 
 ABSTRACTS not published in full papers
 
  1. Georgopoulos A, Schmidt MI, Plotnick LP, Lee PA, Migeon CJ, Kowarski AA (1978) Continuous monitoring of blood glucose during arginine_insulin growth hormone (GH) stimulation test. Pediatric Res, p. 413.
 
  2. Georgopoulos A, Schmidt MI, Margolis S, Kowarski AA (1978) Bioassay for picogram quantities of plasma glucagon. Diabetes, Suppl 2, p. 476.
 
  3. Lindsey PS, Plotnick LP, Georgopoulos A (1981) Insulin pump: effect on diabetic retinopathy.  Presented at the ARVO meeting.
 
  4. Hadji_Georgopoulos A, Margolis S (1982) Acute lowering of HDL cholesterol following fat ingestion in ketosis_prone diabetics. (Presented at the 64th Ann Meeting of the Endocrine Society.)  
  
  5. Hadji_Georgopoulos A, Margolis S (1982) Insulin pump: A suitable treatment for type IV or V hyperlipoproteinemia in obese diabetics? (Presented at the 1st International Workshop in Insulin and Portable Delivery Systems, Toronto.)
 
  6. Saudek CD, Fischell RE, Imbembo A, Georgopoulos A (1983) Programmable implantable medication systems (PIMPS). (Presented at the 43rd Annual Meeting of the American Diabetes Association.)
 
  7. Derogatis LR, Georgopoulos A, Saudek CD (1986) Psychological factors predictive of glycemic control in diabetics on insulin pump therapy. (46th Annual Meeting of the American Diabetes Association.)
 
  8. Feldman SR, Saudek S, Sherman S, Georgopoulos A (1988) Description of a screening program for the detection of diabetic eye disease (DED) in Maryland. (48th Annual Meeting of the American Diabetes Association.)
 
  9. Saudek S, Feldman S, Sherman S, Georgopoulos A (1988) The use of a non-mydriatic fundus camera in detecting previously undiagnosed Diabetic Eye Disease. (48th Annual Meeting of the American Diabetes Association.)
 
10. Mulen-Monakil ML, Feldman SR, Georgopoulos A (1989) The impact of insulin pump therapy on diabetic subjects assessed by a self-reported evaluation and HbA1c levels. (49th Annual Meeting of the American Diabetes Association.)
 
11.  Nuttall FQ, Johnson N, Georgopoulos A, and the VA CSDM group (1992) Baseline data on macrovascular disease and lipid parameters in the VA cooperative study. (Presented at  the Endoctrine Society Annual meeting) 
 
12.   Laube BL, Benedict GW, Georgopoulos A (1995) The lung as an alternative route of delivery for insulin in treating patients with non-insulin dependent diabetes  mellitus.  (Presented to the American Thoracic Society annual meeting.)
 
13.   Rajamannan NM, Butiong C, Johnson CM, Georgopoulos A, Fitzpatrick LA (1996) Cell-cell interactions in the development of atherosclerosis: Macrophage conditioned media stimulates vascular smooth muscle cell proliferation and matrix production.  (Presented at the American College of Cardiology annual meeting.)
 
14. Rajamannan NM, Johnson CM, Georgopoulos A, Fitzpatrick LA (1996) Macrophage conditioned media stimulates vascular subendothelial cell proliferation and matrix production.  (Presented at the FASEB annual meeting.)
  
15. Georgopoulos A,  Tsai M (1998). Lack of association of the C677T thermolabile mutation of the5,10 Methylene-Tetrahydrofolate reductase (MTHFR gene with macrovascular disease in type 2 diabetes. (Presented at the 58th National American Diabetes Association meeting.)
  
  ( Dr. Georgopoulos has seven publications in Greek medical journals).