William R. Kennedy M.D.

Current Position:  Professor of Neurology, University of Minnesota

Research Interests and areas of potential collaboration (http://kennedylab.med.umn.edu/):
Diabetic neuropathy

Projects Underway:
Pancreas transplant effects on diabetic neuropathy (DN)
Diagnosis of DN by evaluation of epidermal nerves in skin biopsy
Diagnosis of diabetic autonomic neuropathy in colon and jejunum
Regeneration of epidermal nerves in diabetes by TEM and SEM study of dermal-epidermal basement membrane
Other topics surrounding the topic of diabetic neuropathy

Publications:

Kennedy, W.R., Wendelschafer-Crabb, G., Johnson, T. Quantitation of epidermal nerves in diabetic neuropathy. Neurology 47:1042-1048, 1996.

Kennedy,W.R. and Wendelschafer-Crabb, G. Utility of skin biopsy in diabetic neuropathy. In Seminars in Neurology; Diabetic neuropathy. eds: D. Goldblatt, D. Younger. G. Thieme Inc. NY, NY. 16:163-171, (June) 1996.

Navarro, X., Verd·, E., Wendelschfer-Crabb,G., Kennedy W.R. Immunohistochemical study of skin reinnervation by regenerative axons. J. Comp. Neurol. 380:164-174, 1997.

Low, P. and Kennedy, W.R. Cutaneous effectors as indicators of abnormal autonomic function. In: The Autonomic Nervous System" Ed. I.L.Gibbins and J.L. Morris. Series  Ed. G. Burnstock. 1997.

Kennedy, W.R. and Wendelschafer-Crabb, G. Innervation of non-glabrous skin. In:  Clinical Autonomic Disorders: evaluation and management, 2nd edition. ed: P. A. Low.  Little, Brown & Co., Boston. pp 109-115, 1997.

Navarro X, Sutherland DER, Kennedy WR. Long-term effects of pancreatic transplantation on diabetic neuropathy. Annals Neurology 42:727-736, 1997.

Simone DA, Nolano M, Wendelschafer-Crabb G, Kennedy WR. Intradermal injection of capsaicin in humans: diminished pain sensation associated with rapid degeneration of intracutaneous nerve fibers. J. Neurosci. 1998 18 (21): 8947-8959.

Kennedy WR, Wendelschafer-Crabb G, Johnson T, Nolano M.  A skin blister method to study epidermal nerves in peripheral nerve disease. Muscle and Nerve 22:360-371, 1999.

Nolano, M., Simone, D.A., Wendelschafer-Crabb, G. Kennedy, W.R. Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation. Pain  81:135-145, 1999.

Ceballos D, Navarro X, Dubey N, Wendelschafer-Crabb G, Kennedy WR,  Tranquillo R. Magnetically aligned collagen gel filling a collagen nerve guide improves peripheral nerve regeneration. Exp Neurol 158:290-300, 1999.

Kennedy WR, Wendelschafer-Crabb G. Utility of the skin biopsy method in studies of diabetic neuropathy. In: Clinical Neurophysiology: From Receptors to Perception. Eds: G Comi, CH Lucking, J Kimura, PM Rossini. EEG and Clinical Neurophysiology. Suppl 50. Elsevior Co. Amsterdam 1999; 553-559.

Simone DA, Khalili N, Brederson J-D, Feder C, Wendelschafer-Crabb G, Kennedy WR. Sensory Functions of epidermal nerve fibers in humans. In: Procedings 9th World Congress on Pain Progress in Pain Research and Management Eds: M Devor, MC Rowbotham, Z Wiesenfeld-Hallin. 1999; 16:207-213.

Khalili N, Wendelschafer-Crabb G, Kennedy WR, Simone DA. Psychophysical Assessment of Heat Pain Sensation Using a Small Thermode Detects The Rapid Loss of Epidermal Nerve Fibers Following Topical Application of Capsaicin. Pain 2001;91:241-250.

Nolano M, Crisci C, Santoro L, Barbieri F, Casale R, Kennedy WR, Wendelschafer-Crabb G, Provitera V, Di Lorenzo N, Caruso G. Absent innervation of skin and sweat glands in congenital insensitivity to pain with anhidrosis. Clin Neurophysiol 2000;111:1596-1601.

Kennedy WR, Wendelschafer-Crabb G, Walk D. Utility of skin biopsy and skin blister in neurological practice. J Clin Neuromusc Dis 2000;1:196-203.

Kennedy W.R. Kennedy disease, a historical note. J Clin Neuromusc Dis 2000;2:3-5.

Kennedy WR, Crabb G. Low chapter. Unmyelinated Nerves in Diabetic Neuropathy Assessed by Skin Biopsy and Skin Blister Methods. In: Diabetic Neuropathy. Gries FA, Dyck PJ, Low PA, Tomlinson DR, Ziegler D. (Eds). Stuttgart: Thieme, In Press. 2000.

Nolano M, Provitera V, Crisci C, Saltalamacchia A, Wendelschafer-Crabb G, Kennedy WR, Filla A, Santoro L, Caruso G. Small nerve fiber involvement in Friedreich Ataxia. Ann Neurol. In Press. Jan. 2001.

Sutherland DER, Gruessner RWG, Dunn DL, Matas AJ, Humar A, Kandaswamy R, Mauer SM, Kennedy WR, Goetz FC, Robertson RP, Gruessner AC, Najarian JS. >1000 pancreas transplants at a single institution. Ann Surgery 2001;233:463-501.

Kennedy WR, Khalili N, Wendelschafer-Crabb G, Nolano M, Simone D. Epidermal nerve fibers. Observation on structure and function. Clin Neurophysiology In Press. October 2001.

Kennedy WR, Wendelschafer-Crabb G. Epidermal nerve fibers. Submitted to: Encyclopedia of Neuroscience. In Press, 2001.

Selim, M, Wendelschafer-Crabb, Wabner K, Kennedy WR. Tape Stripping paper.