Cary N. Mariash, M.D.

Current Positions:
Professor, Medicine and Cell Biology/Neuroanatomy, University of Minnesota Medical School, Medicine and Cell Biology/Neuroanatomy

Director, Division of Endocrinology and Diabetes, University of Minnesota Medical School

Research Interests:

Publications:

       Holdy, K.E., and Mariash, C.N.: Adrenal Cortical Regulation, M.D. Thesis, Univ. of California, San Diego, 1972.

       Mariash, C.N., Seelig, S., Schwartz, H.L., and Oppenheimer, J.H.: Rapid synergistic interaction between thyroid hormone and carbohydrate on mRNA-S14 induction. J. Biol. Chem. 261:9583-9586, 1986.

       Hamblin, P.S., Ozawa, Y., Jefferds, A., and Mariash, C.N.: Interaction Between Fructose and Glucose on the Regulation of the Nuclear Precursor for mRNA-S14. J. Biol. Chem. 264:21646-21651, 1989.

       Strait, K., Kinlaw, W.B., Mariash, C.N., and Oppenheimer, J.H.: Kinetics of induction by thyroid hormone of the two hepatic mRNA's coding for cytosolic malic enzyme in the hypothyroid and euthyroid states:  Evidence against an obligatory role of S14 protein in malic enzyme gene expression. J. Biol. Chem. 264:19784-19789, 1989.

       Burmeister, L.A., and Mariash, C.N.: Sucrose alters the processing of the nuclear precursor for mRNA-S14. J. Biol. Chem. 266:22905-22911, 1991.

       Sudo, Y., Goto, Y., and Mariash, C.N.: Location of a glucose dependent response element in the rat S14 promoter. Endocrinology 133:1221-1229, 1993.

       Sudo, Y. and Mariash, C.N.: Two glucose signaling pathways in S14 gene transcription in primary hepatocytes: A common role of protein phosphorylation. Endocrinology 134:2532-2540, 1994.

       Goumaz, M.O., Schwartz, H., Oppenheimer, J.H., and Mariash, C.N.: Kinetic Analysis of the accumulatin and disappearance of precursor and mature rat hepatic  mRNA-S14 response to thyroid hormone. Am. J. Phsyiol. 266: E1001-E1011, 1994.

       Kinlaw, W.B., Church, J.L., Harmon, J.S., and Mariash, C.N.: Direct evidence for a role of the "spot 14" protein in the regulation of lipid synthesis. J. Biol. Chem, 270:16615-16618, 1995.

       Walker, J.D., Burmeister, L.A., Mariash, A., Bosman, J.F.M., Harmon, J., and Mariash, C.N.: Insulin increases the processing efficiency of mRNA-S14 nuclear precursor. Endocrinology 137:2293-2299, 1996.

       Mariash, C.N., Kaiser, F.E., Schwarz, H.L., Towle, H.C., and Oppenheimer, J.H.: Synergism of thyroid hormone and high carbohydrate diet in the induction of lipogenic enzymes in the rat: Mechanisms and implications. J. Clin. Invest. 65:1126-1134, 1980.

       Sudo, Y. and Mariash, C.N.: Lowering glucose depletes a thapsigargin sensitive calcium pool and inhibits S14 gene transcription. Endocrinology 137:4677-4684, 1996.

       Harmon, J.S. and Mariash, C.N.: Identification of a glucose response element in the S14 gene. Mol. Cell. Endo. 123:37-44, 1996.

       Ota, Y., Mariash, A., Wagner, J.L., and Mariash, C.N.: Cloning, expression, and regulation of the human S14 gene. Mol Cell Endo. 126:75-81, 1997.

       Anderson GW, Hagen SG, Larson RJ, Strait KA, Schwartz HL, Mariash CN, Oppenheimer JH: Purkinje cell protein-2 cis-elements mediate repression of hormonal transcriptional activation. Mol Cell Endo 131:79-87, 1997.

       Sandhofer C, Schwartz HL, Mariash CN, Forrest D, Oppenheimer JH: Beta receptor isoforms are not essential for thyroid hormone-dependent regulation of PCP-2 and myelin basic protein gene expression in the developing brains of neonatal rats. Mol Cell Endo 137:109-115, 1998.

       Anderson GW, Larsen RJ, Oas DR, Sandhofer CR, Schwartz HL, Mariash CN, Oppenheimer JH. COUP-TF modulates expression of the Purkinje cell protein-2 gene: a potential role for COUP-TF in repressing premature thyroid hormone action in the developing brain. J Biol Chem 273:16391-16399, 1998.

       Mariash CN.: The thyroid and obesity revisited. Thyroid Today 21:1-9, 1998.

       Kirschner, L. and Mariash, C.N.: Adipose S14 mRNA is abnormally regulated in obese subjects. Thyroid 9:143-148, 1999.

       Liu, B., Li, W., and Mariash, C.N.: Two different gene elements are required for glucose regulation of S14 transcription. Mol Cell Endo 148:11-19, 1999.

       Towle, H.C., Mariash, C.N., Schwartz, H.L., and Oppenheimer, J.H.: Quantitation of rat liver messenger RNA for malic enzyme during induction by thyroid hormone. Biochemistry 20:3486-3492, 1981.

       Mariash, C.N., McSwigan, C., Towle, H.C., and Oppenheimer, J.H.: Glucose and triiodothyronine-dependent induction of malic enzyme in the isolated hepatocyte. J. Clin. Invest. 68:1485-1490, 1981.

       Mariash, C.N., Seelig, S., and Oppenheimer, J.H.: A rapid, inexpensive quantitative technique for the analysis of two-dimensional electrophoretograms. Analyt. Biochem. 121:388-394, 1982.

       Liaw, C., Seelig, S., Mariash, C.N., Oppenheimer, J.H., and Towle, H.C.: Interactions of thyroid hormone and high carbohydrate fat free diet in regulating several rat liver mRNA species. Biochemistry 22:213-221, 1983

       Mariash, C.N., and Oppenheimer, J.H.: Interrelationships of triiodothyronine concentration, metabolism, protein binding, and nuclear occupancy in the induction of malic enzyme by cultured rat hepatocytes. Endocrinology 112:80-85, 1983.

       Mariash, C.N., and Oppenheimer, J.H.: Stimulation of malic enzyme formation in hepatocyte culture by metabolites: Evidence favoring a nonglycolitic metabolite as the proximate induction signal. Metabolism 33:545-552, 1984.

       Carr, F.E., Bingham, C., Oppenheimer, J.H., Kistner, C., and Mariash, C.N.: Quantitative Investigation of Hepatic Genomic Response to Hormonal and Pathophysiological Stimuli by Multivariate Analysis of Two Dimensional mRNA Activity Profiles. Proc. Natl. Acad. Sci. U.S.A. 81:974-978, 1984.