Catherine Beattie Niewoehner, M.D.

Current Position (s): Professor, Department of Medicine, University of Minnesota, Minneapolis, MN

Department of Medicine Staff, endocrinology/metabolism section, Veterans Administration Medical Center, Minneapolis, MN.

Research Interests and areas of potential collaboration:
Principal Investigator:  Regulation of hepatic glycogen metabolism in fed and fasted rats.

Co-investigator:  Use of alendronate in the treatment of osteoporosis due to chronic spinal cord  injury.

Co-investigator:  Effect of androgen deprivation for prostate cancer on bone density.

Principal Investigator:  A randomized study of a combination of insulin and Pioglitazone in the treatment of patients with type 2 diabetes mellitus

Co-Investigator:  VA Cooperative Study #465 - Glycemic control and complications in diabetes mellitus type 2

Selected publications:

1.   Sable, H.Z., Powell, K., Katchian, H., Niewoehner, C. and Kadlic, S.:  Studies on cyclitols XV.  Tetrahedron  26: l509, l970.

2.   Nuttall, F.Q., Theen, J.W., Niewoehner, C. and Gilboe, D.P.:  Response of liver glycogen synthase and phosphorylase to in-vivo glucose and glucose analogues.  Am J Physiol  245 (Endocrinol-Metab 8): E521-E527, l983.

3.   Niewoehner, C.B., Gilboe, D.P. and Nuttall, F.Q.:  Metabolic effects of oral glucose in the liver of fasted rats.  Am J Physiol  246 (Endocrinol-Metab 9): E89-E94, l984.

4.   Niewoehner, C.B. and Nuttall, F.Q.:  Gynecomastia in a hospitalized male population.  Am J Med 77:633-638, l984.

5.   Niewoehner, C.B., Gilboe, D.P., Nuttall, G.A. and Nuttall, F.Q.:  Metabolic effects of oral fructose in the liver of fasted rats.  Am J Physiol  247 (Endocrinol-Metab l0): E505-E512, l984.

6.   Willenbring, M.L., Morley, J.E., Niewoehner, C.B., Heilman, R.O., Carlson, C.H., and Shafer, R.B.:  Adrenocortical hyperactivity in newly admitted alcoholics: Prevalence, course and associated variables.  Psychoneuroendocrinology  9: 415-422, l984.

7.   Gannon, M.C., Niewoehner, C.B. and Nuttall, F.Q.:  Effect of insulin administration on cardiac glycogen synthase and synthase phosphatase activity in rats fed diets high in protein, fat, or carbohydrate.  J Nutr  ll5: 243-25l, l985.

8.   Niewoehner, C.B., Allen, J.L., Boosalis, M., Levine, A.S. and Morley, J.E.:  The role of zinc supplementation in type II diabetes mellitus.  Am J Med  81: 63-68, l986.

9.   Niewoehner, C.B. and Nuttall, F.Q.:  The mechanism of stimulation of liver glycogen synthase by fructose in alloxan-diabetic rats.  Diabetes  35: 705-711, l986.

10.  Niewoehner, C.B.:  Metabolic effects of dietary vs parenteral fructose.  J Am Coll Nutr  5: 443-450, l986.

11.  Niewoehner, C.B. and Nuttall, F.Q.:  Effects of graded intravenous doses of fructose on glycogen synthase in the liver of fasted rats.  Metabolism 36: 338-344, l987.

12.  Niewoehner, C.B.:  Sulfonylurea therapy in non-insulin-dependent diabetes mellitus.  VA Practitioner  4: 87-96, l987.

13.  Niewoehner, C.B.:  Use of sweeteners in the diabetic diet.  in Sweeteners: Health Effects.  Gary M. Williams, ed.  Princeton Scientific Publishing Co., Inc.  Princeton, NJ. 95-105, l987.

14.  Niewoehner, C.B. and Nuttall, F.Q.:  The relationship of hepatic glucose uptake to intrahepatic glucose concentration in fasted rats following a glucose load.  Diabetes 37: 1559-1566, 1988.

15.  Niewoehner, C.B.: Calcium and osteoporosis. Cereal Foods World 33: 784-787, 1988.

16.  Nuttall, F.Q., Gilboe, D.P., Gannon, M.C., Niewoehner, C.B. and Tan, A.W.H.:  Regulation of glycogen synthesis in the liver.  Am J Med  85 (Suppl 5A): 77-85, 1988.

17.  Niewoehner, C.B. and Morgan, W.K.C.:  Extrapulmonary syndromes associated with tumors of the lung,  in Textbook of Pulmonary Diseases,  fourth edition, G.L.Baum and E. Wolinsky, eds.  Little Brown and Co. Boston, MA. 1989.  pp 1265-1287.

18.  Niewoehner, C.B. and Nuttall, F.Q.:  Disposition of a glucose load in fed rats and rats adapted to a high-carbohydrate diet.  Am J Physiol  256: E811-E817, 1989.

19.  Grund, F.M., and Niewoehner, C.B.:  Hyperthyroxinemia in patients receiving thyroid replacement therapy.  Arch Int Med 149: 921-924, 1989.

20.  Niewoehner, C.B.:  Osteoporosis, Ten questions physicians ask.  J Musculoskeletal Med  6: 57-66, 1989.

21.  Cavanaugh, J., Niewoehner, C.B., and Nuttall, F.Q.:  Gynecomastia and cirrhosis of the liver. Arch Intern Med  150: 563-565, 1990.

22.  Niewoehner, C.B., Neil, B. and Martin, T.:  Hepatic uptake and metabolism of oral galactose in adult fasted rats.  Am J Physiol  259: (Endocrinol Metab 22): E804-E813, 1990.

23.   Niewoehner, C.B., and Neil, B.:  Regulation of hepatic glycogen synthesis after an oral galactose load in adult fasted rats.  Am. J. Physiol. 263: E42-E49, 1992.

24.  Niewoehner, C.B.:  Osteoporosis: Questions physicians often ask.  Consultant.  32: 131-139, 1992.

25.  Niewoehner, C.B.:  Extrapulmonary syndromes associated with tumors of the lung,  in Textbook of Pulmonary Diseases,  fifth edition, G.L.Baum and E. Wolinsky, eds.  Little Brown and Co. Boston, MA. 1993.  pp 1443-1466.

26.  Niewoehner, C.B.:  How much of a problem is osteoporosis in men?  Postgraduate Medicine  93: 59-70, 1993.

27.  Niewoehner, C.B. and Nuttall, F.Q.:  Glycogen concentration and regulation of synthase activity in rat liver in vivo. Arch Biochem Biophys.  318: 271-278, 1995.

28.  Niewoehner, C.B.:  Extrapulmonary syndromes associated with tumors of the lung,   in Textbook of Pulmonary Diseases,  sixth edition, G.L.Baum, J.D. Crapo, B.R. Celli and J.B. Karlinsky, eds.  Lippincott-Raven. Philadelphia, PA. 1997.  pp 1419-1436.

29.  Niewoehner, C.B.:   Controversies in medicine. Osteoporosis treatment: scarce data for men pose more questions than answers.  Medical Journal of Allina.  6: 4-7, 1997.

30.  Niewoehner, C.B.:  Endocrinology, general concepts,   in  Endocrine Pathophysiology, first edition.  C.B. Niewoehner, ed. Fence Creek Publishing Company, Madison, CT. 1998  pp 1-8.

31.  Niewoehner, C.B.:  Calcium regulating hormones and metabolic bone disease,   in  Endocrine Pathophysiology,  first editiion.   C.B. Niewoehner, ed. Fence Creek Publishing Company, Madison, CT. 1998  pp 89-115.

32.  Lupo, V. and Niewoehner, C.B.:  Endocrinology of pregnancy and lactation,   in  Endocrine Pathophysiology, first edition.   C.B. Niewoehner, ed. Fence Creek Publishing Company, Madison, CT. 1998  pp 185-209.  

33.  Niewoehner, C.B. and Niewoehner, D.N.:  Steroid-dependent asthma and osteoporosis: risk, prevention and treatment.  Postgraduate Medicine  105: 79-91, 1999

Submitted for Publication:

Niewoehner, C.B. and Nuttall, F.Q.:  Effects of prolonged anesthesia on glycogen synthesis and its regulation.

Books:

Endocrine Pathophysiology,  first editiion.   C.B. Niewoehner, ed. Fence Creek Publishing Company, Madison, CT. 1998  287 pages.

Abstracts:

1.   Niewoehner, C.B., Gilboe, D.P. and Nuttall, F.Q.:  Oral fructose effects on liver glycogen metabolism.  Diabetes  3l (Suppl 2): l58A, l982

2.   Niewoehner, C.B. and Nuttall, F.Q.:  Fructose metabolism in diabetic rats.  Diabetes  32 (Suppl 1): l66A, l983.

3.   Niewoehner, C.B. and Nuttall, F.Q.:  Gynecomastia in a hospitalized male population.  Abstracts 7th Int'l Congress of Endocrinol. July 1-7, l984.  Quebec City, Canada.  p l7l9.

4.   Niewoehner, C.B. and Nuttall, F.Q.:  Mechanism of stimulation of liver glycogen synthase by fructose in diabetic rats.  Diabetes  34 (Suppl l): 23A, l985.

5.   Niewoehner, C.B.:  Digestion, fate of fructose and other carbohydrates.  J Am Coll Nutr  4 :308, l985.

6.   Niewoehner, C.B. and Nuttall, F.Q.:  Liver glucose uptake in fasted and carbohydrate-adapted rats.  Diabetes 35 (Suppl l) :l96A, l986.

7.   Niewoehner, C.B. and Nuttall, F.Q.:  Hepatic disposition of a glucose load in diabetic rats.  Diabetes 36 (Suppl.l): 211A, l987.

8.   Neil, B.J. and Niewoehner, C.B.:  Galactose metabolism in normal fasted rats.  Diabetes 36 (Suppl  l): 213A, l987.

9.   Grund, F.M., Niewoehner, C.B., Larson, B.W. and Shafer, R.B.:  Significance of elevated T4 levels in patients on thyroid replacement therapy.  J Nuc Med  28 (Suppl l): 575, l987.

10.  Niewoehner, C.B. and Nuttall, F.Q.:  Comparison of hepatic glycogen synthesis following a glucose or a fructose load in diabetic rats.  Diabetologia  30: 562A, l987.

11.  Niewoehner, C.B. and Nuttall, F.Q.:  Effects of a glucose vs a fructose load on glycogen synthesis in diabetic rats.  J Am Coll Nutr  6: 446, l987.

12.  Niewoehner, C.B. and Nuttall, F.Q.:  Hepatic glycogen synthesis in fed and fasted rats after a glucose load.  Diabetes  37 (Suppl l): 231A, l988.

13.  Niewoehner, C.B. and Nuttall, F.Q.:  Does the threshold concentration for net hepatic glucose uptake differ in fed and fasted states?  Diabetes  38 (Suppl 2): 227A, 1989.

14.  Niewoehner, C.B.:  Hepatic oxygen uptake, glucose production and glycogen synthesis after a glucose load in normal and diabetic fasted rats in vivo.  Diabetes  39 (Suppl 1): 1104A, 1990.

15.  Niewoehner, C.B:  Regulation of hepatic glycogen synthesis after a glucose load in fed and fasted rats.  J Am Coll Nutr  9: 538, 1990.

16.  Niewoehner, C.B. and Nuttall, F.Q:  A small dose of oral glucose does not stimulate glucose oxidation but does stimulate liver glycogen synthesis in the fasted rat.  Diabetes  40 (Suppl 1): 260A, 1991.

17.  Niewoehner, C.B. and Nuttall, F.Q.:  Oral lactate results in marked hepatic glycogen synthesis without synthase activation in rats.  Diabetes  42 (Suppl 1): 42A, 1993.

18.  Niewoehner, C.B. and Nuttall, F.Q.:  Lactate increases liver glycogen and lowers glucose in alloxan diabetic rats in vivo.  Diabetologia  36 (Suppl 1): A146, 1993.

19.  Niewoehner, C.B. and Nuttall, F.Q.:  Effects of oral fructose vs lactate on liver glycogen synthesis in diabetic rats.  Diabetes  43 (Suppl 1):  43A, 1994.

20.  Niewoehner, C.B. and Nuttall, F.Q.:  Oral glutamine stimulates liver glycogen synthesis in fasted rats.  Diabetes   45 (suppl 1):   164A, 1996.

21.  Niewoehner, C.B. and Nuttall, F.Q.:  Oral glutamine activates liver glycogen synthase but does not result in glycogen accumulation in fasted diabetic rats.  Diabetes  46 (Suppl 1):  230A, 1997