Lincoln R. Potter, Ph.D.

Current Positions:
Assistant Professor in the Biochemistry, Molecular Biology and Biophysics

Research Interests:
Natriuretic peptide receptors, guanylyl cyclases and cGMP signaling
Effect of diabetes on the natriuretic peptide signaling

Projects Underway:
1. Identification of Natriuretic peptide receptor kinases and phoshatases

2. Defining the molecular mechanism of cross-talk between NPR-B and mitogenic signaling pathways

Publications:

Potter, L.R. and Hunter, T. (2001) Guanylyl cyclase-linked natriuretic peptide receptors: structure and regulation. J. Biol. Chem. Jan 10 [epub ahead of print].

Potter, L.R. and Hunter, T. (2000) Activation of PKC Stimulates the Dephosphorylation of Natriuretic Peptide Receptor-B at a Single Serine Residue: a Possible Mechanism of Heterologous Desensitization. J Biol Chem. Oct 6;275(40):31099-106.

Potter, L.R. and Hunter, T. (1999) A constitutively "phosphorylated" guanylyl cyclase-linked atrial natriuretic peptide receptor mutant is resistant to desensitization. Mol Biol Cell. Jun;10(6):1811-20

Potter, L.R. and Hunter, T. (1998) Phosphorylation of the kinase homology domain is essential for activation of the A-type natriuretic peptide receptor. Mol Cell Biol. Apr;18(4):2164-72.

Potter, L.R. and Hunter, T. (1998) Identification and characterization of the major phosphorylation sites of the B-type natriuretic peptide receptor. J Biol Chem. Jun 19;273(25):15533-9.

Potter, L.R. (1998) Phosphorylation-dependent regulation of the guanylyl cyclase-linked natriuretic peptide receptor B: dephosphorylation is a mechanism of desensitization. Biochemistry. Feb 24;37(8):2422-9.