Alan Robert Sinaiko, M.D.

Current Positions:
Professor, University of Minnesota Medical School, Pediatrics and Pharmacology
Director, University of Minnesota, Pediatric Hypertension Clinic

Research Interests:

Publications:

       Munger, R., Gomez-Marin, O, Prineas, R.P. and Sinaiko, A.R.: Elevated blood pressure in Southeast Asian refugee children. Am J Epidemiol 133:1257-1265, 1991.

       Wells, T.G. and Sinaiko, A.R.: Antihypertensive effect and pharmacokinetics of nitrendipine in hypertensive children. J. of Pediatr. 118:638-643, 1991.

       Gomez-Marin O., Prineas R.J. and Sinaiko A.R.: The sodium-potassium blood pressure trial in children: Design, recruitment and randomization. The Children and Adolescent Blood Pressure Program. Controlled Clinical Trials 12:408-423, 1991.

       Arneson, T., Luepker, R., Pirie, P. and Sinaiko, A.: Cholesterol screening by primary care pediatricians. Pediatrics 89:502-505, 1992.

       Mullenbach, V., Kushi, L.H., Jacobson, C., Roth-Yousey, L., Gomez-Marin, O., Prineas, R.P. and Sinaiko, A.R.: Comparison between three-day food records and telephone 24-hour recall for dietary evaluation in adolescents: The Children and Adolescent Blood Pressure Program. J. Am. Diet. Assc. 92:743-745, 1992.

       Sinaiko, A.R., Gomez-Marin, O. and Prineas, R.J.: Effect of low sodium diet or potassium supplementation on adolescent blood pressure. Hypertension 21:989-994, 1993.

       Sinaiko, A.R., Gomez-Marin, O., Smith, C.L. and Prineas, R.J.: Comparison of serum calcium levels between junior high school children with high normal and low normal blood pressure: The Child and Adolescent Blood Pressure Program. Am J Hypertens 7:1045-1051, 1994.

       Vogt, B.A., Kim, Y., Jennette, J.C., Falk, R.J., Burke, B.A., Sinaiko, A.: Anti-neutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis as a complication of propylthiouracil treatment in children. J Pediatr 124:986-988, 1994.

       Sinaiko, A.R.: Treatment of hypertension in children. Pediatr Nephrol 8:603-609, 1994.

       Sinaiko, A.R.: Clinical pharmacology of converting enzyme inhibitors, calcium channel blockers and diuretics. J Hum Hypertens 8:389-394, 1994.

       Paller, M.S., Cahil, B., Harmon, K.R., Miller, R.B., Sinaiko, A.R., Burke, B., Manivel, J.C.: Glomerular disease and lung transplantation. Am J Kid Dis 26:527-531, 1995.

       Sinaiko, A.R.: Current Concepts - Hypertension in children and adolescents. New Eng J Med 335:1968-1973, 1996.

       Sinaiko, A.R., with the National High Blood Pressure Pediatrics Working Group: Update on the task force report (1987) on high blood pressure in children and adolescents. Pediatrics 98:649-658, 1996.

       Sinaiko, A.R. and Michael, A.F.: Reflux nephropathy and hypertension: more whys and wherefores. Lancet 347:633-634, 1996.

       Georgieff, M.K., Mills, M.M., Gomez-Marin, O., Sinaiko, A.R.: Rate of change of blood pressure in premature and full term infants from birth to four months. Pediatr Nephrol 10:152-155, 1996.

       Bendel-Stenzel, M., Najarian, J.S., Sinaiko, A.R.: Renal artery stenosis in infants: Long-term medical treatment before surgery. Pediatr Nephrol 10:147-151, 1996.

       Sinaiko, A.R., Donahue, R.P., Jacobs, D.R., Prineas, R.J.: Relation of rate of growth during childhood and adolescence to fasting insulin, lipids, and systolic blood pressure in young adults. Submitted, New Eng J Med, 1997.

       Luepker, R., Prineas, R., Jacobs, D., Sinaiko, A.: Secular trends of blood pressure and body size in a multi-ethnic adolescent population: 1986-1996. Submitted, Am J Epidemiol, 1997.

       Sinaiko, A.R., Gomez-Marin, O., Prineas, R.J.: Relation of fasting insulin to blood pressure and lipids in adolescents and parents. Hypertension, 30:1554-1559, 1997.

       Simonton, S.C., Soltzman, D.A., Brennom, W., Pergament, M., Drake, G., Sinaiko, A., Priest, J.R.: Cystic renal lymphangiectasia: A distinctive clinicopathologic entity in the pediatric age group. Ped Path Lab Med 17:293-301, 1997.

       Moran, A., Jacobs, D.R., Steinberger, J., Hong, C-P., Prineas, R., Luepker, R., Sinaiko, A.R.: Insulin resistance during puberty: Results from clamp studies in 357 children. Diabetes; 48:2039-2044, 1999.

       Sinaiko AR, Jacobs DR Jr, Steinberger J, Moran A, Luepker R, Rocchini AP, Prineas RJ. Insulin resistance syndrome in childhood: Associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors in 357 clamp studies. J Pediatr, In Press, 2001.

       Sinaiko, AR. Measurement of blood pressure in children. Am J Hypertens, In Press, 2001.

       Valente, AM, Strong, W, Sinaiko, AR. Obesity and insulin resistance in young people. Am Heart J, In Press, 2001.

       Kay, JD, Sinaiko, AR, Daniels, SR. Pediatric hypertension. Am Heart J; In Press, 2001.

       Moran, A., Sinaiko, A.R.: Influence of intrauterine environment on development of insulin resistance. J Pediatr; 136: 567-568, 2000.

       Steinberger, J., Moller, J., Sinaiko, A.R.: Echocardiographic diagnosis of heart disease in apparently healthy adolescents. Pediatrics; 105: 815-818, 2000.

       Schmitz, K., Hong, C-P., Jacobs, D., Steinberger, J., Moran A., Sinaiko, A.: Physical activity is associated with insulin resistance in children. AHA Conference on Cardiovascular Disease Epidemiology and Prevention, 2000.

       Donahue, R.P., Sinaiko, A.R., Prineas, R.J.: Early predictors of persistently elevated blood pressure in young adults: The Minneapolis children's study. AHA Conference on Cardiovascular Disease Epidemiology and Prevention, 2000.

       Sinaiko AR, Jacobs DR Jr, Steinberger J, Moran A, Luepker R, Rocchini AP, Prineas RJ. Insulin resistance syndrome in childhood: Associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors in 357 clamp studies. J Pediatr, In Press, 2001.

       Adrogue, H.E., Sinaiko, A.R. Prevalence of hypertension in junior high school-aged children: Effect of new recommendations in the 1996 updated task force report. Am J Hypertens 2001; 14: 412-414.

       Steinberger, J., Moran, A., Hong C.P., Jacobs, D.R., Sinaiko, A.R. Adiposity in childhood predicts obesity and insulin resistance in young adults. J Pediatr. In Press, 2001

       Arnett, D.K., Glasser, S.P., McVeigh, G., Prineas, R., Donahue, R., Cohn, J.N., Sinaiko, A. Blood pressure and arterial compliance in young adults: The Minneapolis Childrens Blood Pressure Study. Am J Hypertens; 14: 200-205, 2001.

       Steinberger, J., Jacobs, D., Moran, A., Prineas, R., Sinaiko, A. Insulin resistance in thin and heavy children. AHA Conference on Cardiovascular Disease Epidemiology and Prevention, 2000.

       Murtaugh, M.A., Jacobs, D.R., Schmitz, K.H., Moran, A., Steinberger, J., Sinaiko, A.R. Relation of insulin resistance and body size in adolescence to birthweight. 41st Conference on Cardiovascular Disease Epidemiology and Prevention, American Heart Association, 2001.

       Sinaiko AR, Donahue RP, Jacobs DR Jr., Prineas RP. Influence of parent blood pressure and BMI on development of offspring blood pressure and insulin resistance syndrome (IRS). American Society of Hypertension, 2001.

       Sinaiko AR, Daniels S. The use of short-acting nifedipine in children with hypertension: Another example of the need for comprehensive drug testing in children. J Pediatr 2001; 139: 7-9.

       Sinaiko, AR, Lauer, RM, Sanders, SP. End points for cardiovascular drug trials in pediatric patients. Am Heart J 2001; 142: In Press.

       Sinaiko AR, Steinberger J, Moran T, Prineas RP, Jacobs DR, Jr. Contrast between insulin sensitivity and fatness on cardiovascular risk factors in adolescents. American Heart Association, 2001.

       Steffen, L.M., Jacobs, D.R., Jr., Murtaugh, M.A., Moran, A.M., Hong, C-P, Steinberger, J, Sinaiko, A.R. Whole grain food intake is associated with lower body mass index and greater insulin sensitivity among adolescents. American Heart Association, 2001.

       Sinaiko, A.R., Jacobs, D.R., Jr., Steinberger, J., Moran, A. Prineas, R.J.. Insulin resistance predicts changes in blood pressure and other risk factors during adolescence. High Blood Pressure Research Council, 2001.