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Home > Faculty > M. Kent Froberg, D.V.M., M.D.
M. Kent Froberg, D.V.M., M.D.
Associate Professor, Pathology
Professional ExperiencePresident, Association of Clinical Sciences
www.clinicalscience.org
ResearchAtherosclerosis is the leading cause of cardiovascular disease and may lead to myocardial infarction, stroke or gangrene. Risk factors for atherosclerosis include hypertension, diabetes, hypercholesterolemia, cigarette smoking and may include infectious agents such as Chlamydia and cytomegalovirus (CMV). The inflammatory response to CMV and atherogenesis share many elements in common (see figure below). Our research involves studying role of cytomegalovirus infection in atherogenesis and the complex relationship between CMV and pro-inflammatory cytokines within the blood vessel wall. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine produced by vascular endothelium that acts to direct monocytes to blood vessel walls following endothelial injury.
Figure shows an arterial wall depicting major inflammatory
features common to CMV infection and atherosclerosis.
We have used MCP-1 transgenic mice to study the relationship between CMV infection and MCP-1. Murine CMV infection accelerates inflammation in mouse tissues overexpressing MCP-1, while markedly reducing serum MCP-1 levels in MCP-1 transgenic mice. MCMV has a large genome and has multiple molecular means of modifying the host inflammatory response.
We are currently developing a double transgenic mouse (TIE2-rTA/TRE2-MCP-1) that will express MCP-1 in vascular endothelium and be doxycycline inducible. This mouse model should help us determine how CMV interacts with MCP-1 and other pro-inflammatory cytokines to initiate or exacerbate vascular disease and eventually lead to new ways to treat or prevent atherosclerosis.
EducationDVM University of Illinois 1978
MD University of Minnesota 1993
Publications
Fitzgerald, T.J., and Froberg, M.K. Congenital syphilis in newborn rabbits: immune functions and susceptibility to challenge infection at 2 and 5 weeks of age. Infect. and Immun. 1991; 59:1869-1871.
Tomai, M.A., Fitzgerald, T.J., and Froberg, M.K. Macrophage and lymphocyte functions are down-regulated in newborn rabbits. J. Leukoc. Biol. 1992; 51:151-156.
Froberg, M.K., Fitzgerald, T.J., Hamilton, T.R., Hamilton, B., and Zarabi, M. Pathology of congenital syphilis in the rabbit. Infect. and Immun. 1993: 61:4743-4749.
Froberg, M.K., Brown, R.E., Maylock, J., and Poling, E. In utero development of a mediastinal teratoma: a second trimester event. Prenatal Diagnosis 1994; 14:884-887.
Froberg, M.K., Meschter, S.C., Brown, R.E. and Garbes, A.D. Cartilaginous tumors of the larynx: a report of two cases with definitive diagnosis by fine needle aspiration and computerized tomography. Acta Cytolog. 1996; 40:761-764.
Froberg MK, Eckfeldt JH. Response to a question from G. Bertucci, M.D. on the utility of the five-hour glucose tolerance test to diagnose functional hypoglycemia. CAP Today 1996;10:91.
Froberg MK, Eckfeldt JH. Response to a question from G. Bertucci, M.D. on the utility of the five-hour glucose tolerance test to diagnose functional hypoglycemia. Reprinted in Lab Update, SmithKline Beecham Clinical laboratories. Sept 1996.
Froberg, M.K., Hamati, H., Kant, J.A., Addya, K., and Sahlhany, K.E. Primary low grade T-helper testicular lymphoma. Arch. Pathol. Lab. Med 1997; 121:1096-1099.
Pascucci, M., Dorion, P., Makary, A., and Froberg M.K. (corresponding author): Chronic neutrophilic leukemia evolving from a myelodysplastic syndrome. Acta Hematol. 1997; 98:163-166.
Froberg, M.K., Leone, J.P., Jessurun, J., and Sutherland, D.E.R. Fatal disseminated intravascular coagulation following autologous islet transplantation. Human Pathology 1997;28:1295-1298.
Froberg, M.K., Brunning RD, Dorion P, Litz, CE, Torlakovic E. Demonstration of clonality of neutrophils using FISH in a case of chronic neutrophilic leukemia. Leukemia 1998;12:623-626.
Gilcrease M, Guzman M, Froberg K, Pambuccian S. Salivary duct carcinoma. Is a specific diagnosis possible by fine needle aspiration cytology? Acta Cytol 1998;42:1389-1396.
Froberg MK, Brown RE, Gaylord H, Manivel JC. Intra-abdominal desmoplastic small round cell tumor:immunohistochemical evidence for upregulation of autocrine and paracrine growth factors. Annals of Clin Lab Science 1998;28:386-393.
Froberg MK, Garg UC, Stroncek DF, Geis M, McCullough J, Brown DM. Changes in serum osteocalcin and bone specific alkaline phosphate are associated with bone pain in patients administered granulocyte-colony stimulating factor for peripheral stem cell harvest. Transfusion1999;39:410.
Niehans GA, Kratzke RA, Froberg MK, Aeppli DM, Nguyen PL, Geradts J. G1 checkpoint protein P53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder. Br J Cancer 1999;80:1175-1184.
Froberg MK, Seacotte N, Dahlberg E. Cytomegalovirus seropositivity and total cholesterol in young patients. Annals of Clin Lab Science, 2001;31:157-161.
Froberg MK, Adams A, Seacotte N, Parker-Thornburg J, Kolattukudy P. Cytomegalovirus infection accelerates inflammation in vascular tissues overexpressing MCP-1. Circ Res, 2001;89:1224-1230..
Froberg MK, Gerhart DZ, Enerson BE, Manivel C, Guzman-Paz M, Seacotte N, Drewes LR. Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues. Neuroreport 2001;12:761-765.
Zhou S, Tarkov A, Froberg MK, Leino RL, Wallace KB. Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin. Cancer Res 2001;61: 771-777.
Froberg MK. CMV, lipids and atherogenesis. Med Sci Monitor 2002;8: LE 15-16.
Santos DL, Moreno AJM, Leino RL, Froberg MK, Wallace KB. Carvedilol protects against doxorubicin-induced mitochondrial cardiomyopathy. Toxicol Appl Pharmacol 2002; 185:218-227.
Froberg MK, Palavecino-Fasola E, Dykoski R, Gerding DN, Peterson LR, Johnson S. Staphylococcal aureus and Clostridium difficile cause distinct pseudomembranous intestinal diseases. Clin Infect Dis 2004;39:000.
Froberg MK, Dannen D, Bakken J. Babesiosis and HIV. Lancet 2004;363:704..
Froberg MK. CMV Escapes. Annals of Clin Lab Science 2004;34:123-130.
Oliveria PJ, Bjork JA, Santos MS, Leino RL, Froberg MK, Moreno AJ, Wallace KB. Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity. Tox Applied Parmacology 2004;200:159-168.
Froberg MK. Dorion PR, McMartin KE. The role of calcium oxolate crystal deposition in cerebral vessels during ethylene glycol poisoning. Accepted Toxicol Clin Toxicol. 5/05.
Froberg MK, Dannen D, Parker-Thornburg J, Kolattukudy P. Murine Cytomegalovirus infection markedly reduces serum MCP-1 levels in MCP-1 transgenic mice. (in preparation).
Froberg MK, Laposky N, Kendall D, Guarner J. Spontaneous splenic rupture during acute parasitemia of Babesia microti. (in preparation).
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