Jeffrey S. Gilbert, Ph.D.

Contact Information Phone: 218-726-6748 Fax: 218-726-6356 Email: jgilbert@d.umn.edu Address: 321 SMed 1035 Univeristy Drive Duluth, MN 55812

Assistant Professor

Research

My research interests are related to cardiovascular and renal mechanisms of hypertension and endothelial dysfunction in women with preeclampsia and women that have had a prior preeclamptic pregnancy. I also have an ongoing interest in the developmental origins of health and disease, particularly as it pertains to the increased occurrence of the metabolic syndrome in contemporary populations. My laboratory's primary research approach involves physiological, biochemical and molecular biology methods. My current research interests include:

1. The mechanisms controlling the expression of anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFlt-1), a naturally occurring antagonist of vascular endothelial growth factor (VEGF) and how those factors cause endothelial dysfunction and hypertension during preeclampsia.
2. The mechanisms underlying the increased risk for cardiovascular disease observed in women that have previously endured preeclamptic pregnancies.
3. The mechanisms of developmental programming especially as it relates to the increased occurrence of the cardio-metabolic syndrome in children of mothers with complicated pregnancies.

Ph.D. Graduate opportunities in my lab may be pursued through University of Minnesota programs in Integrated Biosciences, or  Cellular and Integrative Physiology.

Education

• Post-doc University of Mississippi Medical Center, Department of Physiology 2006-2007
• Post-docUniversity of Texas Health Sciences Center, San Antonio Texas, Center for Pregnancy and Newborn Research in the Department of Obstetrics and Gynecology 2006
• Ph.D.University of Wyoming, Zoology and Physiology, 2005
• M.A. Minnesota State University, Exercise Physiology, 2002
• B.A.University of Minnesota, Duluth, Exercise Science, 1999

Teaching

Previous Positions

Instructor of Physiology, University of Mississippi Medical Center, Department of Physiology

Publications

Publications on PubMed

Peer-Reviewed Manuscripts - Past Five Years

Mona Sedeek, Jeffrey S Gilbert, Babbette B LaMarca, Mysara Sholook, Derrick L Chandler & Joey P Granger. Role of reactive oxygen species in hypertension produced by reduced uterine perfusion pressure. Am J Hypertens. 2008 Jul 31. PMID: 18670418

JS Gilbert. Sex, Salt and Senescence: sorting out the mechanisms of the developmental origins of hypertension. Hypertension 2008 Apr;51(4):997-9.

BB LaMarca, JS Gilbert, JP Granger. Recent progress Toward the Understanding of the Pathophysiology of Hypertension During Preeclampsia. Hypertension. 2008 Apr;51(4):982-8.

JS Gilbert, BB LaMarca, JP Granger. ACE2 and Ang-(1-7) in the gravid uterus: The new players on the block. Am J Physiol Regul Integ Comp Physiol. 2008 Jan 16; Epub PMID: 18199593

Babbette D. LaMarca, Barbara T. Alexander, Jeffrey S. Gilbert, Mike J. Ryan, Mona Sedeek, Sydney R. Murphy, and Joey P. Granger. Pathophysiology of Hypertension in Preeclampsia: A Central Role for Endothelin? Gend Med 2008; 5 [Suppl A]:S133-138.

JS Gilbert, M Ryan, BB LaMarca, S Roberts, JP Granger. Pathophysiology of Pregnancy Induced Hypertension: Linking Placental Ischemia with Cardiovascular Dysfunction. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H541-50.

Jeffrey S Gilbert, Elizabeth Brandon, Trinity Vera. Fetal Insulin Secretion in Late Gestation: does size matter? J Physiol (Lond) 2007 Dec 15;585(Pt 3):651-2.

BB LaMarca, MJ Ryan, JS Gilbert, S Roberts, JP Granger. Role of inflammatory cytokines in pathophysiology of preeclampsia. 2007Current Hypertension Reports, 9:480-485.

JS Gilbert, SA Babcock, JP Granger. Hypertension produced by reduced uterine perfusion is associated with increased soluble sFlt-1 expression. Hypertension 2007. 50(6):1142-7.

Sholook MM, Gilbert JS, Sedeek MH, Huang M, Hester RL, Granger JP. Systemic hemodynamic and regional blood flow changes in response to chronic reductions in uterine perfusion pressure in pregnant rats. Am J Physiol Heart Circ Physiol 2007 Oct;293(4):H2080-4.

JS Gilbert, M Dukes, BB LaMarca, K Cockrell, S Babcock, JP Granger. Effects of Reduced Uterine Perfusion Pressure on Blood Pressure and Metabolic Factors in the Pregnant Rat. Am J Hypertens 20:686-691, 2007.

JS Gilbert, SP Ford, AL Lang, MC Drumhiller, LR Pahl, SA Babcock, PW Nathanielsz and MJ Nijland. Nutrient Restriction Impairs Nephrogenesis in a Gender Specific Manner in the Ovine Fetus. Ped Res 61:42-47. 2007.

SP Ford, BW Hess, MM. Schwope, M.J. Nijland, JS Gilbert, KA Vonnahme, WJ Means, H Han, P W Nathanielsz. Maternal undernutrition during early gestation in the ewe results in altered growth, adiposity and glucose tolerance in male offspring.  J Anim Sci. 2007 May;85(5):1285-94.

L.A. Cox, M.J. Nijland, J.S. Gilbert, N.E. Schlabritz-Loutsevitch, G.B. Hubbard, T.J. McDonald, R.E. Shade and P.W. Nathanielsz. Effect of thirty percent maternal nutrient restriction from 0.16 to 0.5 gestation on fetal baboon kidney gene expression. J Physiol 572(Pt 1):67-85, 2006.

JS Gilbert, LA Cox, G Mitchell, MJ Nijland. The Fetal Intrauterine Environment and the Cardiorenal Connection in Hypertensive Offspring. Expert Rev Cardiovasc Ther 4(2):227-37, 2006.

Gilbert JS, Lang AL and Nijland MJ. Maternal nutrient restriction and the fetal left ventricle: Decreased angiotensin receptor expression. Reprod Biol Endocrinol 3: 27, 2005.

JS Gilbert, AL Lang, AR Grant, and MJ Nijland.Maternal Nutrient Restriction in Sheep: Hypertension, Decreased Nephron Number and Altered Renal RAS Expression in Offspring at Nine Months. J Physiol 565: 137-147, 2005.

Published Abstracts - Past Five Years

Jeffrey S Gilbert, S Ananth Karumanchi, Lillian Fournier, Kathy Cockrell, Joey P Granger.Vascular endothelial growth factor decreases blood pressure in hypertensive pregnant rats. Faseb Journal . 2008 22:969.2

Drew Colson, Jeffrey S Gilbert, Jason Bridges, Matt Dukes, Sara A Babcock, Michael Ryan, Joey P Granger. Oxidative stress mediates soluble Flt-1 induced vascular dysfunction in pregnant rats.Abstract. Faseb Journal. 2008 22:969.7

Jason Bridges, Jeffrey S Gilbert, Drew Colson, Matt Dukes, Sara A Babcock, Michael J Ryan, Joey P Granger. Soluble Flt-1 induces vascular dysfunction and reduces fetoplacental weight in pregnant rats.Abstract. Faseb Journal. 2008 22:969.3

Murphy SR, LaMarca BB, Cockrell K, Gilbert JS, Granger JP. Soluble fms-like tyrosine-1 (sFlt-1) production in response to placental ischemia and hypoxia in placenta of pregnant rats.  Faseb Journal.

JS Gilbert, SA Babcock, BB LaMarca, K Cockrell, JP Granger. Hypertension produced by reduced uterine perfusion pressure is associated with increased soluble sFlt-1 expression. Hypertension 2007;50(4):E108.LaMarca B, Speed J, Babcock S, Berry H, Cockrell K, Gilbert JS, Granger JP. Hypertension in response to chronic reductions in uterine perfusion in pregnant rats: Effect of TNF-alpha blockade. Hypertension 2007;50(4):E108.

Gilbert JS, Dukes M, Babcock SA, Cockrell K, LaMarca B and Granger JP. Effects of  reduced uterine perfusion pressure on blood pressure and metabolic factors in the pregnant rat. Faseb Journal 21: A894, 2007.

Gilbert JS, Cox LA, Babcock SA, Shade R, Nathanielsz PW, Nijland MJ. 2006 Gender specific effects of moderate maternal nutrient restriction (NR) in the first half of pregnancy on fetal renal renin-angiotensin system (RAS). J Soc Gynecol Investig. 13:207A

Gilbert JS, Cox LA, Langone G, Glenn J, Shade J, Nathanielsz PW, Nijland MJ. 2006 Maternal nutrient restriction (NR) in the first half of pregnancy decreases vascular endothelial growth factor (VEGF) in fetal baboon kidney. J Soc Gynecol Investig. 13:207A

Gilbert JS, Engels K, Lang L, Grant A, Nathanielsz PW, Nijland MJ 2005 Altered angiotensin II (ANG II) receptor expression in right ventricle (RV) of sheep with programmed hypertension. J Soc Gynecol Investig.12:339A-340A

Gilbert JS, Lane LJ, Lang L, Grant AR, Nathanielsz PW, Nijland MJ 2005 Increased angiotensin II (ANG II) receptor AT1 expression and caspase-3 activity in left ventricle of sheep with programmed hypertension. J Soc Gynecol Investig.12:340A

Schmitz T, Gilbert JS, Nathanielsz PW 2005 EP4 receptor is responsible for PGE(2)-induced metalloproteinase (MMP)-8 synthesis in the pregnant rat cervix. J Soc Gynecol Investig.12:132A

Babcock SA, Gilbert JS, Lang AL, Nijland MJ 2005 Gene transcription of steroidogenic enzymes across mid-gestation in the ovine fetal adrenal. Faseb Journal 19:A189

Gilbert JS, Lang AL, Han HC, Hanson TR, Nathanielsz PW, Ford SP, Nijland MJ 2004 Dysregulation of angiotensin II AT1 and AT2 receptor expression in the left ventricles of IUGR fetuses from ewes undernourished during early to mid-gestation. J Soc Gynecol Investig.11:360A

Gilbert JS, Lang AL, Nijland MJ, Nathanielsz PW, Ford SP 2004 Elevated VEGF and Flk mRNA in left ventricles of IUGR fetuses from ewes undernourished from early to mid-gestation. J Soc Gynecol Investig.11:242A

Gilbert JS, Nijland MJ, Lang AL, Hertz CM, Nathanielsz PW, Ford SP 2004 Glucose intolerance and hypoinsulinemia following an intravenous glucose tolerance test in male offspring of ewes malnourished from early to mid-gestation. J Soc Gynecol Investig.11:242A

Nijland MJ, Ford SP,Gilbert J, Loehle M, Rhoads A, Vonnahme KA, Nathanielsz PW 2004 Maternal under nutrition from early to mid-gestation in sheep induces cardiac remodeling and hypertension in offspring at 9 months of age. Biol Reprod 109

Lang AL, Gilbert J, Pahl L, Nathanielsz PW, Ford SP, Nijland MJ 2004 Nutrient restriction impacts AT2 sub-populations in mid-gestation ovine fetal heart. Faseb Journal 18:A683

Nathanielsz PW, Gilbert J, Loehle M, Rhoads A, Ford SP, Nijland MJ 2004 Increased sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis in sheep at 9 months of age following maternal undernutrition from early to mid-gestation. Biol Reprod108-109

Gilbert JS, Nijland MJ, Lang AL, Hess BH, Nathanielsz PW, Ford SP 2004 Increased weight gain and hyperleptinemia in male progeny of ewes undernourished from early to mid-gestation. J Soc Gynecol Investig.11:106A

Gilbert JS, Vonnahme KA, Nijland M, Nathanielsz PW, Ford SP 2003 Maternal Undernutrition during early to mid-gestation alters fetal development in the ovine fetus. J Soc Gynecol Investig.10:349A

Vonnahme KA, Gilbert JS, Nijland MJ, Nathanielsz PW, Ford SP. 2003 Influence of a constant nutrient restriction from early to mid-gestation on maternal and fetal blood glucose concentration and hepatic glycogen content in the sheep.  J Soc Gynecol Investig.10:228A

Gilbert JS, Vonnahme KA, Nijland MJ, Nathanielsz PW, Ford SP 2003 Impacts of gender and re-alimentation after maternal nutrient restriction from early to mid gestation on kidney development in the ovine fetus. Biol Reprod 68:290

Ford SP, Vonnahme KA,Gilbert JS, Hess BW, Nijland MJ, Nathanielsz PW 2003 Placentomal differentiation may compensate for maternal nutrient restriction from early to mid gestation in rambouillet ewes adapted to range conditions. Biol Reprod 68:225

Kimura Y, Nathanielsz PW, Aida K, Vonnahme KA, Gilbert JS, Ford SP, Nijland MJ 2003 Basal fetoplacental vascular tone in sheep at mid gestation: Role of nitric oxide. Biol Reprod 68:155-156

Nijland MJ, Kimura Y, Aida K, Vonnahme KA, Gilbert JS, Ford SP, Nathanielsz PW 2003 Ovine fetal placentomal arteries at 78 days gestation lack functional endothelin-B receptor subtype activity. Biol Reprod 68:156