Contact Information Phone: 218-726-7432 Fax: 218-726-8014 Email: amhartz@d.umn.edu Address: 275 SMed 1035 University Dr. Duluth, MN 55812

Research Associate

Research

The Blood-Brain Barrier is the interface between blood and brain that resides within the capillary endothelium. This barrier is highly active, dynamic and selective and responds to signals from periphery and brain in both health and disease. One key element of barrier function is the drug efflux transporter, P-glycoprotein. It protects the brain from toxic compounds, but at the same time, also restricts therapeutic drugs from entering the brain. This makes P-glycoprotein the primary obstacle to successful therapy of brain disorders. Therefore it is important to understand physiological and pathophysiological mechanisms that regulate P-glycoprotein at the blood-brain barrier. Such an understanding holds the promise to improve pharmacotherapy of brain disorders such as stroke, brain tumors, epilepsy, neuro-AIDS, Parkinson's and Alzheimer's disease. My research is focused on the following topics:

• Role of P-glycoprotein in Alzheimer's Disease
• Modulation of P-glycoprotein during CNS Inflammation
• Cross-talk between P-glycoprotein and the Innate Immune Response

Education

Publications

Hartz A.M.S., Bauer B., Block M.L., Hong J.S. and Miller D.S. Diesel Exhaust Particles Induce Oxidative Stress, Pro-Inflammatory Signaling, and P-glycoprotein Upregulation at the Blood-Brain Barrier, FASEB Journal, 22(8): 2723-2733, 2008

Bauer B.,Hartz A.M.S., Lucking J.R., Yang X., Pollack G.M. and Miller D.S. Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTπ, at the blood-brain barrier, Journal of Cerebral Blood Flow and Metabolism 28(6):1222-34, 2008

Bauer B., Hartz A.M.S. Pekcec A., Toellner K., Miller D.S. and Potschka H. Seizure-induced upregulation of P-glycoprotein at the blood-brain barrier through glutamate and COX -2, Molecular Pharmacology, 73(5):1444-1453, 2008

Bauer B., Hartz A.M.S. and Miller D.S., TNF-α and Endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier, Molecular Pharmacology 71(3):667-675, 2007

Bauer B., Yang X., Hartz A.M.S., Olson E.R., Zhao R., Kalvass J.C., Pollack G.M. and Miller D.S., In vivo activation of human PXR tightens the blood-brain barrier to methadone through P-glycoprotein upregulation, Molecular Pharmacology 70(4):1212-1219, 2006

Hartz A.M.S., Bauer B., Fricker G. and Miller D.S., Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by TNF-α and LPS, Molecular Pharmacology 69(2):462-470, 2006

Hartz A.M.S., Bauer B., Fricker G. and Miller D.S., Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1, Molecular Pharmacology 66(3):387-394, 2004

Bauer B., Hartz A.M.S., Fricker G. and Miller D.S., Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier, Molecular Pharmacology 66(3):413-419, 2004

Miller D.S., Bauer B. and Hartz A.M.S. Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy; Pharmacological Reviews 60(2):196-209, 2008

Hartz A.M.S., Bauer B., Baehr C.H., Miller D.S. and Fricker G., Drug delivery across the blood-brain barrier, Current Topics in Pharmacology 1: 203-209, 2005

Bauer B., Hartz A.M.S., Fricker G. and Miller, D.S. (Invited Review), Modulation of P-glycoprotein transport function at the blood-brain barrier, Experimental Biology and Medicine 230(2):118-27, 2005