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Home > Faculty > Teresa Rose-Hellekant, MS, DVM, Ph.D.

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Teresa Rose-Hellekant, MS, DVM, Ph.D.



Contact Information

Phone: 218-726-6621
Fax: 218-726-6356
Email:trosehel@d.umn.edu
Address:
341 SMed
1035 University Drive
Duluth, MN  55812

http://www.med.umn.edu/duluth

Assistant Professor

Research

The overall goal of our research program is to study the interaction of growth factors and ovarian hormones on the natural history of mammary cancer development.  Much of experiments utilize genetically engineered mice which express transforming growth factor alpha (TGFalpha) in the mammary gland.  These mice have a high incidence of mammary tumor development.  In addition the tumors which develop in TGFalpha mice represent a special type of clinical breast cancer: those which express estrogen receptor but which do not any longer express progesterone receptor.  This clinical breast cancer type is often refractory to antiestrogen therapy so our TGFa mouse model may prove useful in dissecting the mechanism of antiestrogen resistance.  In addition, we use breast cancer cells in culture to determine the role of signal transduction cascades in promoting cell survival and proliferation.  Techniques used include: histological evaluations of tissues and gene expression analysis using microarray technology (Affymetrix) and quantitative PCR. In addition, total and phosphoprotein levels are measured using immunohistochemistry and western blotting.  Finally, in vitro cell cycle dynamics are evaluated by flow cytometry. 

Education

  • University of Wisconsin, Madison, WI, B.S., Meat & Animal Science
  • University of Wisconsin, Madison, WI, M.S., Veterinary Science
  • University of Wisconsin, Madison, WI, D.V.M., Veterinary Medicine
  • University of Wisconsin, Madison, WI,  Ph.D., Veterinary Science: Reproductive Physiology

Teaching

Endocrinology especially reproduction.  I teach Medical and Pharmacy students as well as graduate and undergraduates includingMedical Endocrinology 6762, Pharmacy 6061, Physiology 5601 and Physiology 3011.

Publications

  1. Rose, T.A. and Bavister, B.D. (1992): Effect of oocyte maturation medium on in vitro development of in vitro fertilized bovine embryos. Mol. Reprod. Dev. 31:72-77.
  2. Bavister, B.D., Rose-Hellekant, T.A. and Pinyopummintr, T. (1992): Development of in vitro matured/in vitro fertilized bovine embryos in defined culture media. Theriogenology 37:127-146.
  3. Fischer, B., Rose-Hellekant T.A., Sheffield, L.G., Bertics, P.J. and Bavister, B.D. (1994): Binding of epidermal growth factor and transforming growth factor-? in mammalian preimplantation embryos. Theriogenology 41: 879-887.
  4. Rose-Hellekant, T.A. and Bavister, B.D. (1996): Roles of protein kinase A and C in spontaneous maturation and in forskolin or 3-isobutyl-1-methylxanthine maintained meiotic arrest of bovine oocytes. Mol. Reprod Dev. 44:241-249.
  5. Rose-Hellekant, T.A. and Bavister, B.D. (1996): Precocious oocyte maturation is induced by an inhibitor of cAMP-dependent protein kinase in the intact golden hamster. Mol. Reprod. Dev. 44:250-255.
  6. Rose-Hellekant, T.A., Libersky-Williamson, E.A. and Bavister, B.D. (1998): Energy substrates and amino acids provided during in vitro maturation of bovine oocytes alter acquisition of developmental competence. Zygote 6:285-294.
  7. Rose-Hellekant, T.A., Sandgren, E.P. (2000): Transforming growth factor alpha- and c-myc-induced mammary carcinogenesis in transgenic mice. Oncogene 19:1092-1096.
  8. Rose-Hellekant TA, Schroeder M, Brockman JL, Zhdankin O, Bolstad R, Chen KS, Gould M, Schuler LA, Sandgren EP. Estrogen receptor positive mammary tumorigenesis in TGFa transgenic mice progresses with progesterone receptor loss. In preparaton
  9. Schroeder M.D., Rose-Hellekant, T.A., Sandgren, E.P., Schuler, L.A. (2001): Dysregulation of mammary stats 1,3 and 5 and PRL receptors by overexpression of TGF? Mol Cell Endocrinology 175: 173-183.
  10. Rose-Hellekant T.A., Gilchrist K., Sandgren E. P. (2002): Genetic strain background alters mammary gland lesion phenotype in TGF? transgenic mice. American Journal of Pathology 161:1439-1447.
  11. Rose-Hellekant, T.A., Arendt L, Schroeder M.D., Gilchrist K.W., Sandgren E.P., and Schuler, L.A. (2003): Prolactin induces ER? positive and ER? negative mammary cancer in transgenic mice. Oncogene. 22:4664-4674.
  12. Arendt LM, Rose-Hellekant TA, Sandgren EP, Schuler LA 2006 Prolactin potentiates transforming growth factor alpha induction of mammary neoplasia in transgenic mice. American Journal of Pathology. Accepted.
  13. Rose-Hellekant TA, Wentworth KM, Nikolai, S, Kundel DW, Sandgren EP Mammary carcinogenesis is preceded by altered epithelial cell turnover in TGFa and c-myc transgenic mice. Submitted.
  14. Rose-Hellekant TA, Schroeder M, Brockman JL, Zhdankin O, Bolstad R, Chen KS, Gould M, Schuler LA, Sandgren EP Estrogen receptor positive mammary tumorigenesis in TGF? transgenic mice progresses with progesterone receptor loss. In preparation.


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