Lois Jane Heller, Ph.D.
Professor
Research
General research interests include influences of various pathophysiological conditions upon cardiac function. Specific current interests and projects include studies of the effects of healthy aging upon cardiovascular reflexes, role of gender and genetic predisposition to cardiovascular disease upon development of cardiac failure.
Education
1964 - BA degree (Biology and Chemistry), Albion College, Albion, MI
1966 - MS degree (Physiology), University of Michigan, Ann Arbor, MI
1970 - PhD degree (Physiology), University of Illinois Medical Center, Chicago, IL
Teaching
- Cardiovascular Physiology (Meds)
- Gastro-Intestinal Physiology (Meds)
- Undergrad/grad teaching in Phsl 3011, Phsl 5601, Phsl 5602, Phsl 8401
- Course Director for Gastro-Intestinal Hepato-Biliary Medicine Course (Med)
- Course Director for Phsl 3011 (Undergrad Physiology Course)
- Course Director for Phsl 8401
Publications
Textbook
D. E. Mohrman and L. J. Heller. Cardiovascular Physiology. McGraw-Hill Book Company, New York, Sixth Edition, 2006. ( A textbook for medical and allied health students)
Recent Peer-Reviewed Manuscripts
Solem, L. E., L. J. Heller, and K. B. Wallace. Dose-dependent induction of cardiac mitochondrial calcium cycling and cell killing by adriamycin. J. Mol. Cell. Cardiol. 28:1023-1032, 1996.
Lear, P. M., L. J. Heller, and J. R. Prohaska. Cardiac hypertrophy in copper-deficient rats is not attenuated by angiotensin II receptor antagonist L-158,809. Proc. Soc. Exp. Biol. Med.212:284-292, 1996.
Heller, L. J., J. A. Opsahl, S. E. Wernsing, R. Saxena and S. A. Katz. Myocardial and plasma renin-angiotensinogen dynamics during pressure-induced cardiac hypertrophy. Am J. Physiol. 274 (Regulatory Integrative Comp. Physiol. 43): R849-856, 1998.
Heller, L. J. and D. E. Mohrman. Comparison of blood pressure responses to intra-arterial and intra-venous injections of angiotensin I, angiotensin II and bradykinin. Life Sciences 62: PL 121-125, 1998.
Prohaska, J. R. and L. J Heller. Calcium reintroduction decreases viability of cardiac myocytes from copper-deficient rats. J. Nutr. 129:1842-1845, 1999.
Heller, L. J. and S. A. Katz. Influence of enalapril on established pressure-overload cardiac hypertrophy in low and normal renin states in female rats. Life Sciences 66:1423-1433, 2000
Katz, S. A., J. A. Opsahl, S. E. Wernsing, L. M. Forbis, J. Smith and L. J. Heller. Myocardial renin is neither necessary nor sufficient to initiate or maintain ventricular hypertrophy. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278:R578-R586, 2000.
Heller, L. J., D. E. Mohrman and J. R. Prohaska. Decreased passive stiffness of cardiac myocytes and cardiac tissue from copper-deficient rat hearts. Am. J. Physiol. Heart Circ Physiol 278: H1840-1847 2000.
Adams, A. and L. J. Heller. Production of high-titer stocks of the English strain of rat cytomegalovirus. J. Virological Methods 86:173-177, 2000.
Zhou, S. , L. J. Heller and K. B. Wallace. Interference with calcium-dependent mitochondrial bioenergetics in cardiac myocytes isolated from doxorubicin-treated rats. Toxicol. and Appl. Pharmacol. 175:60-67, 2001
Heller, L. J., D. E. Mohrman, J. A. Smith and K. B. Wallace. Multi-track system for superfusing isolated cardiac myocytes. Am. J. Physiol. Heart Circ Physiol 284: H1872-1878, 2003
Recent Published Abstracts
Heller, L. J., J. A. Smith, D. E. Mohrman and K. B. Wallace. A simple method for simulating ischemia and reperfusion conditions in isolated cardiac myocytes. FASEB J. 14:A683, 2000.
Heller, L. J., D. E. Mohrman and K.B. Wallace. Effects of simulated ischemia and reperfusion on cardiac myocytes isolated from adriamycin-treated rats. FASEB J 15: A766, 2001.
Heller, L. J., J. N. Denninger and K. B. Wallace. Responses of isolated hearts from adriamycin-treated rats to global ischemia and reperfusion. FASEB J 16:A858, 2002.
Heller, L. J., K. Stephenson, J. Denninger and K. B. Wallace. Reduced cold tolerance of cardiac myocytes isolated from adriamycin-treated rats. FASEB J 17: A518, 2003.
Heller, L. J., E. Hermanson, A Siders, J. A. Bjork and K. B. Wallace. Cardiac and hepatic antioxidant enzyme activity following chronic adriamycin treatment. FASEB J 17: A880, 2003.
Heller, L. J., and J. N. Denninger. Pyruvate + iodoacetate attenuates cardiotoxic effect of cyanide on isolated rat hearts. FASEB J 18: A1005-6, 2004.
Heller, L. J. and P. A. Lennox. Age-dependent blunting of the heart rate component of reflex adjustments to postural changes does not compromise blood pressure control. FASEB J 19:LB 46, 2005.
Fettig, P, A Tobias, L Heller, F Apple and L. Sharkey. Genetic predisposition to cardiovascular disease potentiates delayed doxorubicin cardiotoxicity during pregnancy. FASEB J 20: in press, 2006
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