Edward T. Knych, Jr., Ph.D.

Mechanisms of alcohol induced effects in the cardiovascular and nervous systems

Mechanisms of tolerance and dependence to alcohol

Education

Biology, B.S., 1964, Loyola University, Chicago
Physiology, M.S., 1966, Creighton University, Omaha, Nebraska
Pharmacology, Ph.D., 1970, West Virginia University

Teaching

Course Director: MED 6520, Principles of Basic Medical Sciences and MED 6762, Endocrine and Reproductive Sytems

Lecturer: MED 6520, Principles of Basic Medical Sciences; MED 6573, Nervous System; MED 6746, Fluids and Electrolytes; MED 6762, Endocrine and Reproductive Sytems

Facilitator, Problem Based Learning, MED 6728, Respiratory System; MED 6746, Fluids and Electrolytes

Developer, educational CDs

Publications

E. T. Knych and R. Eisenberg. Effect of amphetamines on plasma corticosterone in the conscious rat. Neuroendocrinology, 29:110-118, 1979.

E. T. Knych and R. Eisenberg. Effect of fluoxetine and metergoline on amphetamine-induced rise in plasma corticosterone. Life Sci. 26:1489-1496, 1980.

E. T. Knych and J. R. Prohaska. Effect of chronic intoxication and naloxone on the ethanol-induced increase in plasma corticosterone. Life. Sci. 28:1987-1994, 1981.

E. T. Knych. Cross tolerance between ethanol and levorphanol to the drug-induced rise in plasma corticosterone. Life Sci. 31:527-532, 1982.

E. T. Knych. Tolerance to ethanol induced contraction of vascular smooth muscle: role of the endothelium. Life Sci. 35:611-617, 1983.

E. T. Knych. The role of the endothelium in tolerance to ethanol-induced contractions of the rat aorta. 2nd Congress of the International Society for Biomedical Research on Alcoholism, Santa Fe, NM, 1984.

E. T. Knych and J. A. Thomas. Pituitary, Hormone in Pharmacology in Medicine: Principles and Practice. S. N. Pradhan, Ed., S. P. Press International, Bethesda, MD, 1986, pp. 385-395.

E. T. Knych and J. A. Thomas. Male Gonadal Hormone and Anabolic Steroids in Pharmacology in Medicine: Principles and Practice, S. N. Pradhan, Ed., S. P. Press International, Bethesda, MD, 1986, pp 458-463.

E. T. Knych. Endothelium dependent transfer of ethanol tolerance in the aorta. Life Sci. 40:1903-1908, 1987.

E. T. Knych. Anti-inflammatory Agents in Drugs, Athletes, and Physical Performance, J.A. Thomas, Ed., Plenum Publishing Corp., NY, 1988, pp105-117.

E. T. Knych. The role of the endothelium in tolerance to ethanol-induced contractions of the rat aorta. Alcoholism Clin. Exp. Res. 11:112-117, 1987.

E. T. Knych. Ethanol and Portal Blood Flow in Alcohol and Drug Abuse Reviews: Vol II. Liver Pathology and Drugs of Abuse. R. R. Watson, Ed., Humana Press, Clifton, N.J., 1991, pp 287-308.

E.T. Knych. Effect of acute and chronic ethanol on nonadrenergic, noncholinergic neurotransmission, Ann. N.Y. Acad. Sci. 654:467-468, 1992.

E.T. Knych. Endothelium-dependent tolerance to ethanol-induced contraction of the rat aorta: effect of inhibition of EDRF action and nitric oxide synthesis. Alcoholism: Clin. Exp. Res. 16:58-63 1992.

E.T. Knych. Ethanol inhibits nonadrenergic-noncholinergic neurotransmission in the anococcygeus muscle of the rat. Alcoholism: Clin Exp Res.18:566-570, 1994.

Wittmers, L., E.T. Knych and D. Brissett. A walk in their shoes: learning about alcohol abuse may not come from textbooks. Minnesota Physician 10 (6): 28-29, 1996.

Olson, L.J, E.T.Knych, T.C. Herzig and J.G. Drewett. Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. Hypertension 29:254-261 1997.

Eisenberg, R.M., Knych, E.T., et al: Alcoholism: A Study and Review Program™, Version 1.0. Center for Technology Enhanced Education and Research, University of Minnesota School of Medicine, Duluth, 2001.

Eisenberg, R.M., Knych, E.T., et al; Geriatric Pharmacology, Minnesota EduWare, Duluth, 2007.

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Education

Teaching

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