Calendar

First Year
Second Year

Medical School, Duluth Home

Medical Students, Duluth

Medical School, Twin Cities

Home > Faculty > John W. Nichols

John W. Nichols

Contact Information

Phone:	218-529-5160
Fax:
Email:	nichols.john@epa.gov
Address:

Toxicologist, adjunct

Research

Development of PBTK and bioenergetics-based models for fish and wildlife; use of microdialysis sampling methods to obtain in vivo metabolism information; development of systems models for compounds that act by endocrine disrupting modes of action

Education

1978, B.A., Zoology, University of Washington
1981, M.S., Fisheries Science, University of Washington
1987, Ph.D., Toxicology, Oregon State University

Professional Merits

Professional Societies

Society of Toxicology; member, Biological Modeling Specialty Section
Northland Chapter of the Society of Toxicology; Councilor, 2006-to date
Society of Environmental Toxicology and Chemistry
Midwest Chapter of the Society of Environmental Toxicology and Chemistry

Selected Appointments/Honors/Major Awards:

Scientific and Technological Achievement Award, U.S. EPA, AA physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish,@ 2006
Superior Accomplishment Award, Mid-Continent Ecology Division, Duluth, 2004. For service as Acting Associate Director for Science.
Scientific and Technological Achievement Award, U.S. EPA, APhysiologically based toxicokinetic model for maternal transfer of 2,3,7,8- tetrachlorodibenzo-p-dioxin in brook trout (Salvelinus fontinalis),@ 2000
Special Act Award, U.S. EPA, Session Chair, 5^th NHEERL Symposium on Indicators in Risk Assessment, 2000
Special Act Award, U.S. EPA, for development of an NHEERL Wildlife Research Strategy, 1999
Special Act Award, U.S. EPA, for contributions to TCDD brook trout study, 1999
ACTION Award (Silver Medal), U.S. EPA, for contributions to Mercury Study Report to Congress, 1977
Special Act Award, U.S. EPA, for contributions to the Mercury Study Report to Congress, 1996
Scientific and Technological Achievement Award, U.S. EPA, "3-Dimensional visualization of physiologically-based kinetic model outputs," 1995
Scientific and Technological Achievement Award, U.S. EPA, "Use of physiologically-based models in a mechanistic approach to aquatic toxicology," 1995
Scientific and Technological Achievement Award, U.S. EPA, "A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish," 1991

Publications

Nichols, J.W., Hoffman, A.D., Fitzsimmons, P.N., and Lien, G.J. 2008. Use of on-line microdialysis sampling to determine the in vivo rate of phenol glucuronidation in rainbow trout. Drug Metab. Disposit. 36:1406-1413.

Nichols, J.W., Hoffman, A.D., Fitzsimmons, P.N., and Lien, G.J. 2008. Quantification of phenol, phenyl glucuronide, and phenyl sulfate in the blood of unanesthetized rainbow trout by on-line microdialysis sampling. Toxicol Mech. Meth. 18:405-412.

Nichols, J., Erhardt, S., Dyer, S., James, M., Moore, M., Plotzke K., Segner, H., Schultz, I., Vasiluk, L., and Weisbrod, A. 2007. Workshop report: Use of in vitro absorption, distribution, metabolism, and excretion (ADME) data in bioaccumulation assessments for fish. Human Ecol. Risk Assess. 13:1164-1191.

Hornung, M., Cook, P., Fitzsimmons, P., Kuehl, D., and Nichols, J. 2007. Tissue distribution and metabolism of benzo[a]pyrene in embryonic and larval medaka (Oryzias latipes). Toxicol. Sci. 100:393-405.

Fitzsimmons, P.N., Lien, G.J., and Nichols, J.W. 2007. A compilation of in vitro rate and affinity values for xenobiotic biotransformation in fish, measured under physiological conditions. Comp. Biochem. Physiol. 145(C):485-506.

Nichols, J.W., Fitzsimmons, P.N., and Burkhard, L.P. 2007. In vitro-in vivo extrapolation of hepatic biotransformation data for fish: II. Modeled effects on chemical bioaccumulation. Environ. Toxicol. Chem. 26:1304-1319.

Nichols, J.W., Schultz, I.R., and Fitzsimmons, P.N. 2006. In vitro-in vivo, extrapolation of hepatic metabolism data for fish: I. A review of methods and strategy for incorporating intrinsic clearance estimates into chemical kinetic models. Aquat. Toxicol. 78:74-90.

Nichols, J.W., Echols, K.R., Tillitt, D.E., Secord, A.L., and McCarty, J.P. 2004. Bioenergetics-based modeling of individual PCB congeners in nestling tree swallows from two contaminated sites on the upper Hudson River, NY. Environ. Sci. Technol. 38:6234-6239.

Echols, K.R., Tillitt, D.E., Nichols, J.W., Secord, A.L., and McCarty, J.P. 2004. Bioaccumulation of PCB congeners in nestling tree swallows (Tachycineta biocolor) on the Hudson River, NY. Concentrations, patterns and accumulation rates. Environ. Sci. Technol. 38:6240-6246.

Nichols, J.W., Fitzsimmons, P.N., Whiteman, F.W., Dawson, T.D., Babeu, L., and Juenemann, J. 2004. A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish. I. Feeding studies with 2,2',5,5'-tetrachlorobiphenyl. Toxicol. Sci. 77:206-218.

Nichols, J.W., Fitzsimmons, P.N., and Whiteman, F.W. 2004. A physiologically based toxicokinetic model for dietary uptake of hydrophobic organic compounds by fish. II. Simulation of chronic dosing scenarios. Toxicol. Sci.. 77:219-229.

Feedback | Notice of Privacy Practices

©2002-2008 Regents of the University of Minnesota. All rights reserved.	Trouble seeing the text? \| Contact U of M \| Privacy
The University of Minnesota is an equal opportunity educator and employer.	Last modified on Tuesday Feb 13, 2007