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Kendall Wallace, Ph.D.

Contact Information

Phone:	218-726-8899
Fax:	218-726-8014
Email:	kwallace@d.umn.edu
Address: 256 SMed 1035 University Dr. Duluth, MN 55812

Professor
Director, Toxicology Graduate Program
Diplomate, American Board of Toxicology
Fellow, Academy of Toxicological Sciences

Research

The focus of our research is on the biochemical and molecular mechanisms by which foreign chemicals including pharmaceuticals, pesticides, environmental pollutants, and industrial compounds interact with biological systems to cause adverse, toxic tissue damage. We are particularly interested in the mitochondrion as a primary intracellular target of chemical-induced toxicity. In addition to studying bioenergetic poisons, we are also investigating the mechanistic basis of metabolic diseases caused by exposure to chemicals that interfere with the molecular biology of the mitochondrion. This includes interference with mitochondrial DNA replication and biogenesis, expression of the mitochondrial genome, mitochondrial protein synthesis, and assembly and incorporation of the individual respiratory complexes in the inner mitochondrial membranes. Implicit to these investigations is identifying and understanding the regulation of transcription factors responsible for the coordinated expression of the nuclear and mitochondrial genomes. We believe that mitochondrial biogenesis is a well-coordinated, multifaceted and dynamic process that is essential to the adaptation of the cell to changing metabolic environments and that interference with this compensatory mechanism underlies the bioenergetic disorders associated with assorted chemically-related toxicities.

Drug-Induced Mitochondrionopathies

Education

Ph.D. Michigan State University, 1979
Post Doc, University of Iowa

Laboratory Personnel

James Bjork, Assistant Scientist
Elisaveta Petkova, Senior Laboratory Technician
Josiah Ray, Graduate Student
Annette Rod, Junior Scientist
Andrew Skildum, Post-Doc
Mark Walters, Graduate Student

Publications and Professional Activities

Publications on PubMed

Patents
Cyclodextrin Compositions and Methods of Treating Viral Infections. March 21, 2002
SLWK Dkt No. 600.538PRV; UoM File No. Z0166
KB Wallace, MA Khan, RW Carlson, SA Rice, and MK Froberg.

Editorships
Editor: Toxicology
Associate Editor: Cardiovascular Toxicology

Books
Molecular Biology of the Toxic Response (eds., A. Puga and K.B. Wallace) Taylor & Francis (1998)

Free Radical Toxicology: Target Organ Toxicology Series (ed., K.B. Wallace), Taylor & Francis (1997)

Book Chapters
Starkov, A. and Wallace, K.B. (in press). “Yin and Yang of Mitochondrial ROS Generation” In: Oxidative Stess, Disease and Cancer (ed., K. Singh).

Wallace, K.B. “Doxorubicin-induced Mitochondrial Cardiomyopathy.” In: Mitochondria in Pathogenesis (eds., J.J. Lemasters and A.-L. Nieminen). Chapter 25, pp467-488. Kluwer Academic/Plenum Publishers, New York. (2001).

Wallace, K.B. "Free Radical-Mediated Chemical Cardiomyopathies." (Chapter 11) In: Free Radical Toxicology: The Target Organ Toxicology Series (ed., K.B. Wallace). Taylor and Francis (1997).

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