Claudio Brunstein, M.D., Ph.D.

Dr. Brunstein is an Assistant Professor in the Hematology, Oncology and Transplantation (HOT) Division and works primarily on the Adult Blood and Marrow Transplantation service. Dr. Brunstein received his M.D. in 1990 from the Universidade Federal do Rio Grande do Sul, Brazil. He did his internal medicine residency training and subspecialty training in clinical oncology in Brazil. He subsequently did his PhD in Medicine doing research in lung cancer. In 1998, he started a Fellowship in Hematology and Transplantation at the University of Minnesota. During that time his interests shifted toward stem cell biology and bone marrow transplantation, and he did a Bone Marrow Transplant Fellowship at the University of Minnesota.  He joined the Faculty in 2004.

Dr. Brunstein's clinical interest is the treatment of hematologic malignancies and blood and marrow transplantation. His research interests focus on the use hematopoietic stem cells for treatment of hematologic disorders. He is involved in research investigating the use of alternative sources of hematopoietic stem cells, in special umbilical cord blood, supportive care and related reduced intensity conditioning regimens.

Selected Publications

Brunstein CG, Hirsch BA, Miller JS, McGlennen RC, Verfaillie CM, McGlave PB, Weisdorf DJ. Non-leukemic autologous reconstitution after allogeneic bone marrow transplantation for Ph-positive chronic myelogenous leukemia: extended remission preceding eventual relapse. Bone Marrow Transplant. 2000; 26:1173-7.

Brunstein CG, McGlave PB. The biology and treatment of chronic myelogenous leukemia. Oncology (Williston Park). 2001; 15:23-31; discussion 31-2, 35 (Review).

Brunstein CG, Hirsch BA, Hammerschmidt D, McGlennen RC, Nguyen PL, Verfaillie CM. Leukemia in donor cells after allogeneic hematopoietic stem cell transplant. Bone Marrow Transplant. 2002; 29:999-1003.

Askari S, Nollet K, Debol SM, Brunstein CG, Eastlund T. Transfusion-related acute lung injury during plasma exchange: Suspecting the unsuspected. J Clin Apher. 2002; 17:93-6.

Dudek AZ, Lesniewski-Kmak K, Bliss RL, Brunstein C, Condon DL, Kratzke RA. Pilot phase II study of gemcitabine and vinorelbine in patients with recurrent or refractory small cell lung cancer. Lung. 2005; 183:43-52.

Jacobson P, Long J, Rogosheske J, Brunstein C, Weisdorf D. High unbound mycophenolic acid concentrations in a hematopoietic cell transplantation patient with sepsis and renal and hepatic dysfunction. Biol Blood Marrow Transplant. 2005; 11:977-8.

Majhail NS, Weisdorf DJ, Wagner JE, Defor TE, Brunstein CG, Burns LJ. Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphoma. Blood. 2006; 107:3804-7.