Yvonne Datta, MD

Dr. Datta is an Associate Professor in the Division of Hematology, Oncology, and Transplantation.  She received her medical degree from the University of Minnesota.  She completed a residency in internal medicine at the Medical College of Virginia in Richmond, followed by a clinical fellowship in hematology/oncology at the University of Michigan, Ann Arbor.  She completed additional research training in hematology at the Brigham & Women’s Hospital, Harvard Medical School.  Prior to coming to the University of Minnesota, she held faculty positions at the Medical College of Wisconsin and Emory University.

Dr. Datta’s research focus is on platelet function defects, characterizing the pathophysiology and genetics of platelet disorders in humans and in rodent models.  She also has an interest in platelet interactions with vascular endothelium and malignant cells. Her clinical interests include all of hematology, with a special emphasis on disorders of hemostasis and thrombosis.

Selected Publications

Datta YH, Romano M, Jacobson BD, Golan DE, Serhan CN, Ewenstein BM .  Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells.  Circulation, 92, 3304-11, 1995.

Datta YH, Youssoufian H, Marks PW, Ewenstein BM.  Targeting of a heterologous protein to a regulated secretion pathway in cultured endothelial cells.  Blood, 94, 2696-2703, 1999.

Datta YH and Ewenstein BM.  Regulated secretion in endothelial cells:  Biology and clinical implications.  Thrombosis and Haemostasis, 86, 1148-1155, 2001.

Datta YH, Wu FC, Dumas PC, Ning G, Datta MW, Rangel-Filch A, Cooley BC, Majewski R, Provoost AP, Jacob HJ.  Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat. Thrombosis and Haemostasis, 89, 1031-1042, 2003.

Datta YH, Kampalath B, Binion DG.  Rituximab-induced remission of a gastric MALT lymphoma.  Leukemia and Lymphoma. 45, 1297-1299, 2004.

Cooley BC, Chen C-Y, Friedman K, Datta Y.  A Prothrombotic Phenotype in the Copenhagen Rat Strain.  Thrombosis Research, 115, 153-157, 2005.

Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ.  RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J. Am. Soc. Nephrol., 16, 852-6, 2005.