Dr. Geng received his M.D. and Ph.D. from Shanghai Medical University in 1988. He was a post-doctoral fellow in the laboratory of Dr. Rodger P. McEver at the University of Oklahoma Health Sciences Center in Oklahoma City. He then served as Research Group Leader at the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences before coming to the University of Minnesota.
Adhesion and migration of mammalian cells are of crucial importance in a number of biological events, such as fertilization, embryogenesis, pattern, tissue and organ formation, and in a variety of physiological and pathological processes, including lymphocyte trafficking, leukocyte recruitment, hemostasis, wound healing, tumor angiogenesis and cancer metastasis. All these cellular interactions are precisely regulated by temporal and spatial presentation of various cell adhesion molecules and chemotactical molecules displaying appropriate specificity and affinity for proper development and functioning of the organism.
Dr. Geng's research is focused on the structures and functions of vascular endothelial cells, with special interests in the biological roles of endothelial cells in mediating adhesion and migration of leukocytes, platelets and cancer cells. He is also very interested in their pathological roles in inflammation, thrombosis, cancer growth and metastasis. His lab is currently working on 1) the signal transduction of P-selectin (CD62P)/P-selectin Glycoprotein Ligand-1 (CD162) in the interactions among leukocytes, platelets, cancer cells and endothelial cells; 2) the redox regulation of NF-κB activation in endothelial cells; and 3) the Slit-Robo interaction in tumor angiogenesis as well as in cancer growth and metastasis.
Selected Publications
Geng, J.-G. (2001) Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies. Cell Res. 11:85-88.
Ma, Y.-Q., and Geng, J.-G. (2002) Obligatory requirement of sulfation for P-selectin binding to human salivary gland carcinoma Acc-M cells and breast carcinoma ZR-75-30 cells. J. Immunol. 168:1690-1696.
Li, L., Qian, K.-X., and Geng, J.-G. (2002) A 28-kDa glycoprotein functions as a platelet ligand for P-selectin (CD62P). Thromb. Haemost. 87:706-711.
Zhao Z, Qian Y, Xia Y-F, Geng J.-G., Li X. (2003) IFN regulatory factor-1 is required for the up-regulation of the CD40-NF-κB activator 1 axis during airway inflammation. J. Immunol. 170:5674-5680.
Wang, B., Xiao, Y., Ding, B.-B., Zhang, N., Yuan, X.-b., Gui, L., Qian, K.-X., Duan, S., Chen , Z., Rao, Y., and Geng, J.-G. (2003) Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell 4:19-29. (A preview describing this study was simultaneously published in the same issue of Cancer Cell 4:1-2)
Wang, J.-G., and Geng, J.-G. (2003) Affinity and kinetics of P-selectin binding to heparin. Thromb. Haemost. 90:309-316.
Pei XH, Lin ZX, Geng JG. (2008) [Expression and identification of recombinant P-selectin and P-selectin glycoprotein ligand 1.] [Article in Chinese] Sheng L Xue Bao. 60:520-524.
Chen MX, Chen JL, Lu JL, Hong J, Chen WX, Zhu JS, Chen NW, Geng JG. (2008) [Inhibition of bFGF gene expression and tumor angiogenesis of orthotopic implantation of human gastric carcinoma by N-desulfated heparin.] [Article in Chinese] Zhonghua Yi Xue Za Zhi. 25:78-81.
Wang LJ, Zhao Y, Han B, Ma YG, Zhang J, Yang DM, Mao JW, Tang FT, Li WD, Yang Y, Wang R, Geng JG. (2008) Targeting slit-roundabout signaling inhibits tumor angiogenesis in chemical-induced squamous cell carcinogenesis. Cancer Sci. 99:510-517.
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