Kalpna Gupta, Ph.D.

Dr Gupta is an Assistant Professor in the Hematology, Oncology and Transplantation Division in the Department of Medicine at the University of Minnesota.

Dr Gupta received her Ph.D. degree in Biochemistry in 1984 from the All India Institute of Medical Sciences, New Delhi, India. She subsequently did her Post-doctoral training in the Hematology, Oncology and Transplantation Division at the University of Minnesota.

Dr Gupta's research interest is in vascular biology and molecular mechanisms of angiogenesis. Her work encompasses opioid and VEGF signaling with regard to angiogenesis-dependent pathophysiological conditions including cancer and retinopathy.

Selected Publications

Gupta K, Ramakrishnan S, Browne PV, Solovey A, Hebbel RP. A novel technique for culture of human dermal microvascular endothelial cells under either serum-free or serum-supplemented conditions: isolation by panning and stimulation with vascular endothelial growth factor. Exp Cell Res 1997; 230:244-51.

Gupta K, Gupta P, Ramakrishnan S, Hebbel RP. Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: Effect on human microvascular endothelial cell proliferation and angiogenesis. Angiogenesis 1999; 3: 147-158.

Gupta K, Kshirsagar S, Li W, Gui L, Ramakrishnan S, Gupta P, Law PY, Hebbel RP VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res 1999; 247: 495-504.

Gupta K, Kshirsagar S, Schwartz R, Chang L, Law PY, Yee D, Hebbel RP. Morphine stimulates angiogenesis by activating pro-angiogenic and survival-promoting signaling and promotes breast tumor growth. Cancer Res 2002: 62, 4991-8.

Gupta K, Zhang J.  Angiogenesis: A curse or a cure?  Postgraduate Medical Journal 2005; In Press.

Poonawala T, Levay-Young BK, Hebbel RJ, et al.  Opioids heal ischemic wounds in rats. Wound Repair and Regeneration 2005; 13:165-174.

Farooqui M, Geng ZH, Stephenson EJ, Zaveri N, Yee D, Gupta K. Naloxone acts as an antagonist of estrogen receptor activity in MCF-7 cells. Mol Cancer Ther 2006; 5: 611-20.