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Robert P. Hebbel, MD

Regents Professor and George Clark ProfessorDOMHOT_Faculty_Hebbel11
Director, Vascular Biology Center


Mailing Address:
Medicine - Hematology, Oncology and Transplantation
Mayo Mail Code 480
420 Delaware Street SE
Minneapolis, MN 55455

Phone: (612) 624-0123
Fax: (612) 625-6919
Email: hebbe001@umn.edu
Preferred method of contact: email
 

Areas of expertise:

  • Sickle disease
  • Endothelial biology
  • Hematology
     
Biography
Dr. Hebbel received an MD degree from the University of Minnesota in 1973 and subsequently trained in Internal Medicine at the University of Washington, Seattle and Hematology at the University of Minnesota. Dr. Hebbel is a member of the Cancer Center, the Biomedical Engineering Institute, and the Lillehei Heart Institute. In addition, he is Director of the Vascular Biology Center.
 
Research Interests
Dr. Hebbel's research interests include: the vascular pathobiology of sickle disease; use of blood outgrowth endothelial cells (BOEC) for biomedical applications; and the role of genetically determined differences in endothelial biology as a determinant of clinical phenotypic heterogeneity of vascular disease. Dr. Hebbel's lab is currently emphasizing, respectively, the molecular physiology of tissue factor expression by endothelial cells, utility of BOEC for gene therapy and device coating, and role of inherited endothelial cell differences underlying stroke risk.
 
Academic Distinctions
• American Society of Clinical Investigation (1985)
• American Association of Physicians (1997)
 
Selected Publications
Hebbel RP, Eaton JW, Kronenberg RS, Zanjani ED, Moore LD, Berger EM. Human llamas: Adaptation to altitude in subjects with high hemoglobin oxygen affinity. J Clin Invest 662:593-600, 1978

Hebbel RP, Boogaerts MAB, Eaton JW, Steinberg MH. Erythrocyte adherence to endothelium in sickle cell anemia: Possible determinant of disease severity. New Engl J Med 302:992-995, 1980

Hebbel RP, Morgan WT, Eaton JW, Hedlund BE. Accelerated autoxidation and heme loss due to instability of sickle hemoglobin. Proc Natl Acad Sci USA 85:237-241, 1988

Solovey A, Lin Y, Browne P, Choong S, Wayner E, Hebbel RP: Circulating activated endothelial cells in sickle cell anemia. New Engl J Med 337:1584-1590, 1997

Solovey A, Gui L, Key NS, Hebbel RP: Tissue factor expression by endothelial cells in sickle cell anemia. J Clin Invest 101:1899-1904, 1998.

Lin Y, Weisdorf DJ, Solovey A, Hebbel RP: Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 105:71-77, 2000

Lin Y, Chang L, Solovey A, Healey JF, Lollar P, Hebbel RP: Use of blood outgrowth endothelial cells for gene therapy of hemophilia A. Blood 99:457-462, 2002.

Hebbel RP, Osarogiagbon R, Kaul D. The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy. Microcirculation 11:129-151, 2004

Shet AS, Aras AO, Gupta K, Hass M, Rausch DJ, Saba N, Koopmeiners L, Key NS, Hebbel RP: Sickle blood contains tissue factor positive microparticles derived from endothelial cells and monocytes. Blood 102:2678-2683, 2003

Dudek AZ, Bodempudi V, Welsh BW, Jasinski P, Griffin RJ, Milbauer L, Hebbel RP. Systemic inhibition of tumour angiogenesis by endothelial cell-based gene therapy. Br J Cancer 97:513-522, 2007

Chang Milbauer L, Wei P, Enenstein J, Jiang A, Hillery CA, Scott JP, Nelson SC, Bodempudi V, Topper JN, Yang RB, Hirsch B, Pan W, Hebbel RP. Genetic endothelial systems biology of sickle stroke risk. Blood 111:3872-3879, 2008

Hebbel RP, Vercellotti GM, Pace BS, Solovey AN, Kollander R, Abanonu CF, Nguyen J, Wei P, Milbauer LC, Enenstein J, Nguyen J, Pan W, Hebbel RP. Differential endothelial gene expression by African Americans versus Caucasian Americans: A possible contribution to health disparity in vascular disease and cancer. BMC Medicine 9:2, 2011

Mulrooney DA, Ness KK, Solovey A, Hebbel RP, Neaton JD, Peterson BA, Lee CK, Kelly AS, Neglia JP.  Pilot study of vascular health in survivors of Hodgkin lymphoma.  Pediatr Blood Cancer. 2012 Mar 27. doi: 10.1002/pbc.24082. [Epub ahead of print]  PMID:22457206

Manning BM, Hebbel RP, Gupta K, Haynes CL.  Carbon-fiber microelectrode amperometry reveals sickle-cell-induced inflammation and chronic morphine effects on single mast cells. ACS Chem Biol. 2012 Mar 16;7(3):543-51.  PMID:22217155

Sjeklocha LM, Park CW, Wong PY, Roney MJ, Belcher JD, Kaufman DS, Vercellotti GM, Hebbel RP, Steer CJ.  Erythroid-specific expression of β-globin from Sleeping Beauty-transduced human hematopoietic progenitor cells.  PLoS One. 2011;6(12):e29110.  PMID:22216176

Cain DM, Vang D, Simone DA, Hebbel RP, Gupta K.  Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness.  Br J Haematol. 2012 Feb;156(4):535-44.

Martin-Ramirez J, Hofman M, van den Biggelaar M, Hebbel RP, Voorberg J. Establishment of outgrowth endothelial cells from peripheral blood. Nat Protoc. 2012; 7(9):1709-15. PMID: 22918388

Weber ML, Vang D, Velho PE, Gupta P, Crosson JT, Hebbel RP, Gupta K. Morphine promotes renal pathology in sickle mice. Int J Nephrol Renovasc Dis. 2012; 5:109-18. PMID: 22888269

Mulrooney DA, Ness KK, Solovey A, Hebbel RP, Neaton JD, Peterson BA, Lee CK, Kelly AS, Neglia JP. Pilot study of vascular health in survivors of Hodgkin lymphoma. Pediatr Blood Cancer. 2012; 59(2):285-9. PMID: 22457206

Manning BM, Hebbel RP, Gupta K, Haynes CL. Carbon-fiber microelectrode amperometry reveals sickle-cell-induced inflammation and chronic morphine effects on single mast cells. ACS Chem Biol. 2012 Mar 16;7(3):543-51. PMID: 22217155
 

 


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