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  Home > Faculty > Gerhard Johnson, M.D.
 

Gerhard Johnson, M.D.

Dr. Gerhard Johnson

Professor


Mailing Address:
VA Medical Center
Hematology and Medical Oncology (111E)
One Veterans Drive
Minneapolis, MN 55417

Phone: (612) 725-2000
Fax: (612) 725-2149
Email: johns337@umn.edu
Preferred method of contact: email

Areas of Expertise

  • Platelet biology
  • Coagulation disorders

 


 

Biography
Dr. Johnson received his M.D. from the University of Minnesota Medical School in 1962.
 
Research Interests
Dr. Johnson focuses on platelet biology and related coagulation problems. Current studies include: [a] elucidation of thromboxane receptor biology, using the characteristic canine signaling defect as a model to provide evidence that control involves thromboxane receptor phosphorylation; [b] evaluation of the role of platelet serotonin uptake and release in pathogenesis of dexfenfluramine cardiopulmonary toxicity; [c] clinical studies of prophylactic therapy for deep vein thrombosis in high risk orthopedic surgery patients.
 
Selected Publications
Burroughs SF, Johnson GJ. Beta-lactam antibiotic-induced platelet dysfunction: Evidence for irreversible inhibition of platelet activation in vitro and in vivo after prolonged exposure to penicillin. Blood 1990; 75:1473-1480.

Johnson GJ, Leis LA, Francis GS. Adenosine potentiates the inhibitory effects of calcium antagonists on human platelet aggregation induced by thromboxane A2 or U46619. Thromb Res 1990; 59:139-148.

Johnson GJ, Leis LA, King RA. Thromboxane responsiveness of dog platelets is inherited as an autosomal recessive trait. Thromb Haemost 1991; 65:578-580.

Johnson GJ. Platelets, penicillins, and purpura: What does it all mean? J Lab Clin Med 1993; 121:531-533.

Burroughs SF,Johnson GJ. Beta-lactam antibiotics inhibit agonist-stimulated platelet calcium influx. Thromb Haemost 1993; 69:503-508.

Johnson GJ, Leis LA, Dunlop PC. Thromboxane-insensitive dog platelets have impaired activation of phospholipase C due to receptor-linked G protein dysfunction. J Clin Invest 1993; 92:2469-2479.

Johnson GJ, Leis LA, Dunlop PC. Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences. Biochem J 1996; 318:1023-1031.

Dunlop PC, Leis LA, Johnson GJ. Epinephrine correction of impaired platelet thromboxane receptor signaling. Am J Physiol Cell Physiol 2000; 279:C1760-1771.

Johnson GJ, Leis LA, Dunlop PC, Weir EK. The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux. J Thromb Haemost 2003; 1:2663-8.

Johnson GJ, Leis LA, Dunlop PC, Weir EK. The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux. J Thromb Haemost. 2003 Dec;1(12):2663-8. Erratum in: J Thromb Haemost. 2004 Aug;2(8):1504.

Johnson GJ, Leis LA, Krumwiede MD, White JG. The critical role of myosin IIA in platelet internal contraction. J Thromb Haemost. 2007 Jul;5(7):1516-29.

Johnson GJ, Leis LA, Bach RR. Tissue factor activity of blood mononuclear cells is increased after total knee arthroplasty. Thromb Haemost. 2009 Oct;102(4):728-34.
 

 

 

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