Dr. Kaufman is an Associate Professor of Medicine in the Division of Hematology, Oncology, and Transplantation, and member of the Stem Cell Institute at the University of Minnesota.
Dr. Kaufman is a native of the Twin Cities. He did undergraduate work at Stanford University and then completed an MD and PhD (Immunology) at the Mayo Medical School and Mayo Graduate School in Rochester, MN. He then completed both residency training in Internal Medicine and fellowship training in Hematology at the University of Wisconsin-Madison.
Dr. Kaufman joined the faculty at the University of Minnesota in 2002. His research interests focus on hematopoietic and endothelial cell development from human and non-human primate embryonic stem (ES) cells. This research uses ES cells to understand the earliest stages of hematopoiesis. In vitro and in vivo models are used to elucidate both extracellular protein interactions and intracellular genetic regulation that impact these developmental pathways. ES cells offer a unique model to investigate basic developmental biology and may serve as a therapeutic cell source to replace or repair cells or tissues damaged by disease or other degenerative processes.
Selected Publications
Kaufman, Dan S., Renee A. Schoon, Michael J. Robertson, and Paul J. Leibson. Inhibition of selective signaling events in NK cells recognizing major histocompatibility complex class I. Proc. Natl. Acad. Sci. USA 1995; 92: 6484-6488.
Odorico, Jon S., Dan S. Kaufman, and James A. Thompson. Multilineage differentiation from human embryonic stem cell lines. Stem Cells. 2001; 19:193-204.
Kaufman, Dan S., Eric T. Hanson, Rachel L. Lewis, Robert Auerbach, and James A. Thomson. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc. Natl. Acad. Sci. USA. 2001; 98:10716-10721
Kaufman, Dan S. A Scientific Rationale for Human Embryonic Stem Cell Research. Yale Journal of Health Policy, Law, and Ethics. 2002; 2:177-187.
Kaufman, Dan S. and James A. Thomson. Human Embryonic Stem Cells- Hematopoiesis and Transplantation Strategies. Journal of Anatomy. 2002: 200:243-248.
Firpo, Meri T. and Dan S. Kaufman. Embryonic stem cells in the field of hematopoietic stem cells and immune therapy. In. K. Atkinson, W. Fibbe, R. Champlin, P. Ljungman, J. Ritz, and M. Brenner. Clinical Bone Marrow and Blood Stem Cell Transplantation, 3rd Edition. Cambridge University Press, San Francisco, CA. 2003, 76-89.
Chen, Dong, Rachel L. Lewis, and Dan S. Kaufman. Mouse and human embryonic stem cell models of hematopoiesis: Past, present, and future. Biotechniques (supplement on stem cells) 2003; 35:1253-1261.
Kaufman, Dan S., Rachel L. Lewis, Eric T. Hanson, Robert Auerbach, Johanna Plendl, and James A. Thomson. Functional endothelial cells derived from Rhesus monkey embryonic stem cells. Blood 2004; 103:1325-1332.
Uma Lakshmipathy, Beatriz Pelacho, Kazuhiro Sudo, Jonathan L. Linehan, Electra Coucouvanis, Dan S. Kaufman and Catherine M. Verfaillie. Efficient transfection of embryonic and adult stem cells. Stem Cells 2004; 22:101-115.
Tian, Xinghui, Julie Morris, Jonathan Linehan, and Dan S. Kaufman. Cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cells. Experimental Hematology 2004; 32:1000-1009.
Schwartz RE, Linehan JL, Painschab MS, Hu WS, Verfaillie CM, Kaufman DS. Defined conditions for development of functional hepatic cells from human embryonic stem cells. Stem Cells Dev 2005; 14: 643-55.
Qiu C, Hanson E, Olivier E, Inada M, Kaufman DS, Gupta S, Bouhassira EE. Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development. Experimental Hematology 2005; 33: 1450-8.
Woll PS, Martin CH, Miller JS, Kaufman DS. Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity. Journal of Immunology 2005; 175: 5095-103.
Hematti P, Obrtlikova P, Kaufman DS. Nonhuman primate embryonic stem cells as a preclinical model for hematopoietic and vascular repair. Experimental Hematology 2005; 33: 980-6. (review).
Martin CH, Kaufman DS. Synergistic use of adult and embryonic stem cells to study human hematopoiesis. Current Opinion in Biotechnology 2005; 16: 510-5. (review).
Tian X, Kaufman DS. Hematopoietic development of human embryonic stem cells in culture. Methods in Molecular Medicine 2005; 105: 425-36 (review).
Narayan AD, Chase JL, Lewis RL, Tian X, Kaufman DS, Thomson JA, Zanjani ED. Human embryonic stem cell-derived hematopoietic cells are capable of engrafting primary as well as secondary fetal sheep recipients. Blood 2006; 107: 2180-3.
Tian X, Woll PS, Morris JK, Linehan JL, Kaufman DS. Hematopietic engraftment of human embryonic stem cell-derived blood cells is regulated by host innate immunity. Stem Cells 2006; 24:1370-80.
Cameron CM, Hu W-S, Kaufman DS. Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation. Biotechnology and Bioengineering 2006; 94:938-948.
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