Carol Lange, Ph.D.

Dr. Carol Lange, Ph.D. is an Associate Professor in the Departments of Medicine and Pharmacology at the University of Minnesota.  She received her Ph.D. from the University of Colorado School of Pharmacy in 1991. She holds memberships in The Endocrine Society (Full Member) and Women in Endocrinology.  Dr. Lange serves as teaching faculty in the U of MN Department of Pharmacology Graduate Program, Microbiology, Immunology, and Cancer Biology Graduate Program and MD/PhD Combined Program.  She has served on several NIH Study Sections including Biochemical Endocrinology and Metabolic Physiology.

Selected Publications

Lange-Carter CA, Fossli T, Johnsen T, and Malkinson AM. Decreased Expression of the Tpe I Isozyme of cAmp-Dependent Protein Kinase in Tumor Cell Lines of Lung Epithelial Origin. J. Biol. Chem. 265:7814-7818, 1990.

Lange-Carter CA and Malkinson AM. Altered Regulation of mRNA Levels Encoding the Type I Isozyme of cAMP Dependent Protein Kinase in Neoplastic Mouse Lung Epithelial Cells. J. Biol. Chem. 266:22529-22536, 1991.

Lange-Carter CA, Vuillequez JJ and Malkinson AM. 8-Cl-Adenosine Mediates 8-Cl-cAMP Induced Down-Regulation of cAMP-Dependent Protein Kinase in Normal and Neoplastic Mouse Lung Epithelial Cells by a cAMP Independent Mechanism. Cancer Res. 53:393-400, 1993.

Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, and Johnson GL.  A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf. Science, 260:315-319, 1993.

Lange-Carter CA, Pleiman C, and Johnson GL.  A Novel Upstream Activator in the Mitogen Activated Protein Kinase Signal Transduction Pathway.  Recent Prog. Hormone Res. Vol. 49: 341-345, 1993.

Gardner AM, Vaillancourt RR, Lange-Carter CA, and Johnson GL.  MEK-1 Phosphorylation by MEK Kinase, Raf, and MAP Kinase: Analysis of Phosphopeptides and Regulation of Activity. Molec. Biol. Cell,  5: 193-201, 1994.

Johnson GL, Gardner AM, Lange-Carter CA, Qian N-X, Russell M, and Winitz S.  How Does the G Protein, Gi, Transduce Mitogenic Signals? J. Cell. Biochem., 54: 415-422, 1994.

Gardner AM, Lange-Carter CA, Vaillancourt RR, and Johnson GL.  Measuring the Activation of Kinases in the MAP Kinase Regulatory Network.  Methods Enzymol., 238: 258-270, 1994.

Blumer KJ, Johnson GL, and Lange-Carter CA.  Mammalian MEK Kinase Can Function Downstream of Protein Kinase C in a Yeast MAP Kinase Signaling Pathway.  Proc. Natl. Acad. Sci. USA.,  91: 4925-4929, 1994.

Lange-Carter CA, and Johnson GL.  Ras-Dependent Growth Factor Regulation of MEK Kinase (MEKK) in PC12 Cells.  Science, 265: 1458-1461, 1994.

Minden A, Lin A, McMahon M, Lange-Carter CA, Derijard B, Davis RJ, Johnson GL, and Karin M.  Bifurcation in Ras Signaling: Raf-1 and MEKK-1 Differentially Activate ERK and JNK MAP Kinases. Science, 266: 1719-1722, 1994.

Lange-Carter CA, and Johnson GL.  Assay of MEK Kinases.  Methods Enzymol., 255: 290-301, 1995.

Winston BW, Lange-Carter CA, Gardner A, Johnson GL, and Riches DWH.  TNF Rapidly Activates the MEK/MAP Kinase Cascade in an MEK Kinase-Dependent, Raf-1-Independent Fashion in Mouse Macrophages.  Proc. Natl. Acad. Sci. USA., 92: 1614-1618, 1995.

Lin A, Minden A, Martinetto H, Lange-Carter CA, Johnson GL, Mercurio F, Zon LI, and Karin M.  Identification of a JNK Activating Kinase Defines a New Mammalian Mitogen Activated Protein Kinase

Cascade Leading from MEKK to JNK.  Science, 268: 286-290, 1995.

Russell M, Lange-Carter CA, and Johnson GL.  Recognition of Recombinant MEK-1 and MEK2b Expressed in E. Coli..  Biochemistry, 34: 6611-6615, 1995.

Russell M, Lange-Carter CA, and Johnson GL.  Direct Interaction Between Ras and the Kinase Domain of MEK Kinase (MEKK1).  J. Biol. Chem., 270: 11757-11760, 1995.

Johnson NL, Gardner AM, Diener KM, Lange-Carter CA, Gleavy J, Jarp, MB, Minden A, Karin M, Zon LI, and Johnson GL.  Signal Transduction Pathways Regulated by Mitogen-Activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death.  J. Biol. Chem., 271: 3229-3237, 1996.

Groshong SD, Owen GI, Grimison B, Schauer IE, Tod, MC, Langan TA, Sclafan RA, Lange CA, and Horwitz KB.  Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the CDK Inhibitors, p21 and p27Kip1. Molecular Endocrinol., 11: 1593-1607, 1997.

Leslie, K.K., Kumar, N.S., Richer, J., Owen, G., Takimoto, G., Horwitz, K., and Lange, C.  Differential Expression of the A and B Isoforms of Progesterone Receptor in Human Endometrial Cancer Cells: Only PRB is Induced by Estrogen and Associated with Strong Transcriptional Activation.  Annals New York Acad. Sci.  827:17-26, 1997.

Richer JK, Lange CA, Weirman AM, Brooks KM, Tung L, Takimoto GS, and Horwitz KB.  Progesterone Receptor Variants Found in Breast Cells Repress Transcription by Wild-Type Receptors.  Breast Cancer Research and Treatment.  48:231-241, 1998.

Lange CA, Richer JK, Shen T, and Horwitz KB.  Convergence of Progesterone and Epidermal Growth Factor Signaling in Breast Cancer.  Potentiation of Mitogen-Activated Protein Kinase Pathways.  J. Biol. Chem.  273:31308-31316, 1998.

Richer JK, Lange CA, Manning NG, Owen G, Powell R, and Horwitz KB.  Convergence of Progesterone with Growth Factor and Cytokine Signaling in Breast Cancer.  Progesterone Receptors Regulate Signal Transducers and Activators of Transcription Expression and Activity.  J. Biol. Chem.  273:31317-31326, 1998.

Lange CA, Richer JK, and Horwitz KB.  Hypothesis:  Progesterone Primes Breast Cancer Cells for Cross-Talk With Proliferative or Antiproliferative Signals.  Mol. Endo.  13:829-836, 1999.

Lange CA, Shen T, and Horwitz KB. Phosphorylation of Human Progesterone Receptors at Serine 294 by Mitogen Activated Protein Kinase Signals Their Degradation by the 26S Proteasome.  Proc. Natl. Acad. Sci. USA 97: 1032-1037, 2000.

Shen T, Horwitz KB, and Lange CA Transcriptional Hyper-Activity of Human Progesterone Receptors is Coupled to Their Ligand-Dependent Down-Regulation by Mitogen-Activated Protein Kinase-Dependent Phosphorylation of Serine 294. Mol. Cell. Biol. 21: 6122-6131, 2001.

Yee D and Lange CA. Crosstalk between estrogen receptors and growth factor signaling. In Manni A, and Verderame MF (eds). Contemporary Endocrinology; Selective Estrogen Receptor Modulators: Research and Clinical Applications.  Totowa, New Jersey, Humana Press, 2002, pp 77-95.

Pierson-Mullany LK, Skildum A, Faivre E, Lange CA. Cross-talk between growth factor and progesterone receptor signaling pathways: implications for breast cancer cell growth. Breast Dis 18:21-31, 2003.

Qiu M, Lange CA. MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear association.  J Steroid Biochem Mol Biol 85:147-57, 2003 (review).

Qiu M, Olsen A, Faivre E, Horwitz KB, Lange CA. Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors. Mol Endocrinol 17:628-42, 2003.

Lange CA. Making sense of cross-talk between steroid hormone receptors and intracellular signaling pathways: who will have the last word?  Mol Endocrinol 18:269-78, 2004.

Skildum A, Faivre E, Lange CA. Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases. Mol Endocrinol 19:327-39, 2005.

Zhang P, Ostrander JH, Faivre EJ, Olsen A, Fitzsimmons D, Lange CA. Regulated association of protein kinase B/Akt with breast tumor kinase.  J Biol Chem 280: 1982-91, 2005.

Faivre E, Skildum A, Pierson-Mullany L, Lange CA.  Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: role of mitogen-activated protein kinases and cell cycle regulators. Steroids 70:418-426, 2005.