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Manish Patel, D.O.

Assistant Professor DOMHOT Faculty MPatel 2011 GIF


Mailing Address:
Medicine – Hematology, Oncology and Transplantation Office
MMC 480 Mayo
420 Delaware Street SE
Minneapolis, MN 55455

Phone: (612) 624-0123
Fax: (612) 625-6919
Email: patel069@umn.edu
Preferred method of contact: email

Areas of Expertise

  • Lung Cancer
  • Mesothelioma
  • Head and Neck Cancer
  • Experimental therapies
  • Oncolytic viruses

 

Biography
Dr. Patel received a BS in Molecular Biology from Vanderbilt University in 1996. He then attended Kirksville College of Osteopathic Medicine, receiving a Doctor of Osteopathy degree in 2001. Dr. Patel then pursued residency in Internal Medicine at McGaw Medical Center of Northwestern University. He followed this with a clinical research fellowship at Winthrop University Hospital (Mineola, NY) from 2004-2006. In 2006 he joined the Hematology, Oncology and Transplantation fellowship at the University of Minnesota and in July 2010 became a faculty member of the Division.
 
Research Interests
Dr. Patel’s laboratory-based research focuses on the biology of lung cancer and other solid tumors. His current laboratory interests are in developing live, replicating viruses as antitumor therapy for lung cancer and mesothelioma. His laboratory has an interest in learning how to modulate the host immune system to augment the antitumor activity of viral therapy as well as understand the molecular determinants of response and resistance to oncolytic virus therapy.
 
Selected Publications
Whitson BA, Jacobson BA, Frizelle S, Patel MR, Yee D, Maddaus MA, Kratzke RA. Effects of insulin-like growth factor-1 receptor inhibition in mesothelioma. Thoracic Surgery Directors Association Resident Research Award. Ann Thorac Surg. 2006 Sep;82(3):996-1001; discussion 1001-2.

Patel MR, Jacobson BA, De A, Frizelle SP, Janne P, Thumma SC, Whitson BA, Farassati F, Kratzke RA. Ras pathway activation in malignant mesothelioma. J Thorac Oncol. 2007 Sep;2(9):789-95.

Jacobson BA, De A, Kratzke MG, Patel MR, Jay-Dixon J, Whitson BA, Sadiq AA, Bitterman PB, Polunovsky VA, Kratzke RA. Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma. Br J Cancer. 2009 Aug 4;101(3):424-31.

Sadiq AA, Patel MR, Jacobson BA, Escobedo M, Ellis K, Oppegard LM, Hiasa H, Kratzke RA. Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II. Invest New Drugs. 2010 Feb;28(1):20-5.

Patel MR, Sadiq AA, Jay-Dixon J, Jirakulaporn T, Jacobson BA, Farassati F, Bitterman PB, Kratzke RA.  Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation.  Int J Oncol. 2012 Feb;40(2):577-82.


 

 

 

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