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  Home > Faculty > David Potter, MD, PhD
 

David Potter, MD, PhD

Associate ProfessorDOMHOT_Faculty_Potter09
Member, Microbiology,Immunology and
Cancer Biology Training Program


Mailing Address:
Medicine – Hematology, Oncology and Transplantation Office
Mayo Mail Code 480
420 Delaware Street SE
Minneapolis, MN 55455

Phone: (612) 625-8933
Fax: (612) 625-6919
Email: dapotter@umn.edu
Preferred method of contact: email

Areas of Expertise

  • Breast cancer
  • Aerodigestive tract cancers
     

 

Biography
After undergraduate studies in biology at M.I.T., Dr. Potter received M.D. and Ph.D. degrees from Johns Hopkins University. He trained in Internal Medicine at Stanford University Medical Center, and in Hematology and Oncology at Tufts-New England Medical Center. He performed post-doctoral studies at the M.I.T. Center for Cancer Research in the laboratory of Dr. Phillip Sharp. He was on the faculty at Tufts University, the Indiana University Cancer Center and moved to the University of Minnesota in 2006, where he is a member of the Breast Cancer Program at the Masonic Cancer Center.
 
Research Interests
Dr. Potter’s research interests include: the mechanisms of cytochrome P450 epoxygenases in breast cancer progression, pre-clinical cancer drug development and translational breast cancer clinical trials. Also of interest are the mechanisms of calpain proteases in cell motility and cytoskeletal remodeling.
 
Selected Publications

Potter DA, Yee D, Guo Z, Rodriguez M. Should diabetic women with breast cancer have their own intervention studies?  Endocr Relat Cancer 2012 Feb 13;19(1):C13-7.

Mitra R, Guo Z, Milani M, Mesaros C, Rodriguez M, Nguyen J, Luo X, Clarke D, Lamba J, Schuetz E, Donner DB, Puli N, Falck JR, Capdevila J, Gupta K, Blair IA, Potter DA. CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (+/-)-14,15-Epoxyeicosatrienoic Acid (EET). J Biol Chem. 2011 May 20;286(20):17543-59.

Srirangam A, Milani M, Mitra R, Guo Z, Rodriguez M, Kathuria H, Fukuda S, Rizzardi A, Schmechel S, Skalnik DG, Pelus LM, Potter DA. The human immunodeficiency virus protease inhibitor ritonavir inhibits lung cancer cells, in part, by inhibition of survivin. J Thorac Oncol. 2011 Apr;6(4):661-70.

Mitra R, Lee J, Jo J, Milani M, McClintick JN, Edenberg HJ, Kesler KA, Rieger KM, Badve S, Cummings OW, Mohiuddin A, Thomas DG, Luo X, Juliar BE, Li L, Mesaros C, Blair IA, Srirangam A, Kratzke RA, McDonald CJ, Kim J, Potter DA. Prediction of postoperative recurrence-free survival in non-small cell lung cancer by using an internationally validated gene expression model. Clin Cancer Res. 2011 May 1;17(9):2934-46.

Carpenter JS, Rawl S, Porter J, Schmidt K, Tornatta J, Ojewole F, Helft P, Potter DA, Sweeney C, Giesler RB. Oncology outpatient and provider responses to a computerized symptom assessment system. Oncol Nurs Forum. 2008; 35:661-669.

Srirangam A, Mitra R, Wang M, Gorski JC, Badve S, Baldridge LA, Hamilton J, Kishimoto H, Hawes J, Li L, Blum JS, Donner DB, Sledge GW, Nakshatri H, Potter DA. Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer. Clin. Cancer Res. 2006; 12: 1883-1896.

Zhang B, Srirangam A, Potter DA, Roman A. 2005. HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes. Oncogene 2005; 24:2585-2588.

Henley JD, Summerlin DJ, Potter DA, Timmerman RD, Tomich CE. Intraoral mucin-rich salivary duct carcinoma. Histopathology 2005; 47(4):436-437.

Narayanasamy V, Mukhopadhyay S, Palakal M, Potter DA. TransMiner: Mining transitive associations among biological objects from text. Journal of Biomedical Science 2004; 11:864-873.

Glading A, Bodnar R, Reynolds IJ , Shiraha H, Satish L, Potter DA, Blair HC, Wells A. EGF activates m-calpain (calpain 2), at least in part, by ERK-mediated phosphorylation. Mol. Cell. Biol. 2004; 24: 2499-2512.

Potter DA, Srirangam A, Fiacco KA, Brocks D, Maki M, Acheson D, Herman IM. Calpain regulates enterocyte brush border actin assembly and pathogenic E. coli-mediated effacement. J. Biol. Chem. 2003; 278:30403–30412.

Carragher NO, Westhoff MA, Riley D, Potter DA, Dutt P, Elce JS, Greer PA, Frame MC. v-src induced modulation of the calpain-calpastatin proteolytic system regulates both morphological transformation and cell cycle progression. Mol. Cell. Biol. 2002; 22:257-69.

Croce K, Flaumenhaft R, Rivers M, Furie BC, Furie B, Herman IM, Potter DA. Calpain regulates platelet secretion, aggregation and spreading. J. Biol. Chem. 1999; 274:36321-36327.

Potter DA, Tirnauer JS, Janssen R, Croall DE, Hughes CN, Fiacco KA, Mier JW, Maki M, Herman IM.Calpain regulates the actin cytoskeleton during cell spreading. J. Cell Biol. 1998; 141:647-662.

Limentani S, Pretell JO, Potter D, DuBois JS, Dauost PR, Spieler PS, Miller KB. Bone marrow necrosis in two patients with acute promyelocytic leukemia during treatment with all-trans retinoic acid. Am. J. Hematology 1994; 47:50-55.

Potter DA, C. J. Larson CJ, Eckes P, Schmid RM, Nabel GJ, Verdine GL, Sharp PA. Purification of the MHC class I transcription factor H2TF1: the full length product of the nfkb2 gene. J. Biol. Chem. 1993; 268:18882-18890.

Lowell CA, Potter DA, Stearman RS, Morrow JF. Structure of the murine serum amyloid A gene family. J. Biol. Chem. 1986; 261:8442-8452.

Morrow JF, Stearman RS, Peltzman C, Potter DA. Induction of hepatic synthesis of serum amyloid A protein and actin. Proc. Natl. Acad. Sci. USA 1981; 78: 4718-4722.

Potter DA, Fostel J, Berninger M, Cech TR, Pardue ML. DNA-protein interactions in the Drosophila mitochondrial genome as deduced from trimethylpsoralen crosslinking patterns. Proc. Natl. Acad. Sci. USA 1980; 77:4118-4122.

Berninger M, Cech TR, Fostel J, Potter D, Scott M, Pardue ML. The structure and function of the mitochondrial DNA of Drosophila melanogaster. Alfred Benzon Symposium 1978; 13:229-241.

Cech TR, Potter D, Pardue ML. Chromatin structure in living cells. Cold Spring Harbor Symposia on Quantitative Biology 1978; 42:191-197.
 

 

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