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Arne Slungaard, M.D.

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Mailing Address:
Medicine – Hematology, Oncology and Transplantation Office
Mayo Mail Code 480
420 Delaware Street SE
Minneapolis, MN 55455

Phone: (612) 624-0123
Fax: (612) 625-6919
Email: slung001@umn.edu
Preferred method of contact: email

Areas of Expertise

  • Inflammation
  • Hematopoietic stem cell transplantation



 

Biography
Dr. Slungaard received his B.A. from Carleton College, Northfield, Minnesota and his M.D., residency, and Hematology and Oncology subspecialty training at the University of Minnesota. He joined the faculty in 1984. He is the coordinator of Grand Rounds for the Division of Hematology, Oncology and Transplantation.
 
Research Interests
Dr. Slungaard’s clinical interest is in bone marrow and peripheral blood stem cell transplantation. His research interests are 1) the biology and pathology of eosinophil peroxidase-mediated oxidant tissue damage and 2) interactions of cationic proteins such as platelet factor 4 with the thrombomodulin/protein C natural anticoagulant system.
 
Selected Publications
AZ Dudek, CA Pennell, TD Decker, TA Young, NS Key, and Slungaard A. Platelet factor 4 binds to glycanated forms of thrombomudulin and to protein C: Potential anticoagulant role in coagulation. Journal of Biological Chemistry 272: 31785-31792, 1997.

Arlandson M, Decker T, Roongta V, Mayo K, Bonilla L, MacPherson JC, Hazen SL, and Slungaard A. Eosinophil peroxidase oxidation of thiocyanate: characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system. Journal of Biological Chemistry, 276:215-224, 2001.

Ozcan M, Morten CT, Solovey A, Dandelet L, Bach RR, Hebbel RH, Slungaard A, and Key NS. Whole blood tissue factor procoagulant activity remains detectable during severe aplasia following bone marrow and peripheral blood transplantation. Thrombosis and Haemostasis, 85:250-5, 2001.

Toor AA, Slungaard A, Hedner U, Weisdorf DJ, and Key NS. Acquired factor VII deficiency in bone marrow transplant recipients. Bone Marrow Transplantation, 29:403-408, 2002.

Albert CJ, Thukkani AK, Heuertz RM, Slungaard A, Hazen SL, and Ford DA. Eosinophil Peroxidase-Derived Reactive Brominating SpeciesTarget the Vinyl Ether Bond of Plasmalogens Generating a Novel Chemotractant, a-Bromo Fatty Aldehyde. Journal of Biogical Chemistry 278:8942-8950, 2003.

Dudek AZ, Nesmelova I, Mayo K, Verfaillie CM, Pitchford S, De Moor K, and Slungaard A. Platelet Factor 4 (PF4) Promotes Adhesion of Hematopoietic Progenitor Cells and Binds IL-8: Novel Mechanisms for Modulation of Hematopoiesis. Blood 101:4687-4694, 2003.

Slungaard A, Fernández JA, Griffin JH, Key NL, Long JR, Piegors DJ, and Lentz SR. Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood 102:146-151, 2003.

Albert CJ, Thukkani AK, Heuertz RM, Slungaard A, Hazen SL, Ford DA. Eosinophil peroxidase-derived reactive brominating species target the vinyl ether bond of plasmalogens generating a novel chemoattractant, alpha-bromo fatty aldehyde. J Biol Chem 278:8942-50, 2003.

Aras O, Shet A, Bach RR, Hysjulien JL, Slungaard A, Hebbel RP, Escolar G, Jilma B, Key NS. Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia. Blood 103:4545-53, 2004.

Slungaard A. Platelet factor 4 modulation of the thrombomodulin-protein C system (Review). Crit Care Med; 32 (5 Suppl):S331-5, 2004.

Xia YF, Ye BQ, Li YD, Wang JG, He XJ, Lin X, Yao X, Ma D, Slungaard A, Hebbel RP, Key NS, Geng JG. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. J Immunol 173:4207-17, 2004.

Nesmelova IV, Sham Y, Dudek AZ, van Eijk LI, Wu G, Slungaard A, Mortari F, Griffioen AW, Mayo KH. PF4 and IL8 CXC-chemokine heterodimer formation modulates function at the quarternary structural level. J Biol Chem 2004; 280:4948-58.

Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, Fautsch SK, McKenna D, Le C, Defor TE, Burns LJ, Orchard PJ, Blazar BR, Wagner JE, Slungaard A, Weisdorf DJ, Okazaki IJ, McGlave PB. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in cancer patients. Blood 2005; 105: 3051-3057.

Slungaard A. Platelet factor 4: a chemokine enigma. Int J Biochem Cell Biol 2005; 37:1162-7.

Nesmelova IV, Sham Y, Dudek AZ, van Eijk LI, Wu G, Slungaard A, Mortari F, Griffioen AW, Mayo KH. Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level. J Biol Chem 2005; 280: 4948-58.

Tan PL, Wagner JE, Auerbach AD, Defor TE, Slungaard A, Macmillan ML. Successful engraftment without radiation after fludarabine-based regimen in Fanconi anemia patients undergoing genotypically identical donor hematopoietic cell transplantation. Pediatr Blood Cancer 2006; 46: 630-6.

Wang JG, Mahmud SA, Thompson JA, Geng JG, Key NS, Slungaard A. The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states. Blood 2006; 107: 558-65.

Wang J, Slungaard A. Role of eosinophil peroxidase in host defense and disease pathology. Arch Biochem Biophys 2006; 445: 256-60. (review).

Li YD, Ye BQ, Zheng SX, Wang JT, Wang JG, Chen M, Liu JG, Pei XH, Wang LJ, Lin ZX, Gupta K, Mackman N, Slungaard A, Key NS, Geng JG. NF-kappa B transcription factor p50 critically regulates tissue factor in deep vein thrombosis. J Biol Chem. 2009; 284(7):4473-83. PMID: 19095643

Tomblyn MB, Arora M, Baker KS, Blazar BR, Brunstein CG, Burns LJ, Defor TE, Dusenbery KE, Kaufman DS, Kersey JH, Macmillan ML, McGlave PB, Miller JS, Orchard PJ, Slungaard A, Tomblyn MR, Vercellotti GM, Verneris MR, Wagner JE, Weisdorf DJ. Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: Analysis of graft sources and long-term outcome. J Clin Oncol. 2009; 27(22): 3634-41. PMID: 19581540

Hebbel RP, Vercellotti GM, Pace BS, Solovey AN, Kollander R, Abanonu CF, Nguyen J, Vineyard JV, Belcher JD, Abdulla F, Osifuye S, Eaton JW, Kelm RJ Jr, Slungaard A. The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice. Blood. 2010 Mar 25;115(12):2483-90.

Zhang W, Wang J, Wang H, Tang R, Belcher JD, Viollet B, Geng JG, Zhang C, Wu C, Slungaard A, Zhu C, Huo Y. Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. Arterioscler Thromb Vasc Biol. 2010 May;30(5):1000-6.

Warlick ED, Tomblyn M, Cao Q, Defor T, Blazar BR, Macmillan M, Verneris M, Wagner J, Dusenbery K, Aurora M, Bachanova V, Brunstein C, Burns L, Cooley S, Kaufman D, Majhail NS, McClune B, McGlave P, Miller J, Oran B, Slungaard A, Vercellotti G, Weisdorf DJ. Reduced-intensity conditioning followed by related allografts in hematologic malignancies: long-term outcomes most successful in indolent and aggressive non-hodgkin lymphomas. Biol Blood Marrow Transplant. 2011 Jul;17(7):1025-32.
 


 

 


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