Linda Burns, M.D

Area of Expertise: Lymphoma, radioimmunotherapy

Dr. Burns is Professor of Medicine, the Fellowship Director of the Hematology, Oncology and Transplantation (HOT) Division, and Medical Director of the Inpatient Adult Bone Marrow Transplant Unit at Fairview-University Medical Center, Minneapolis.

Dr. Burns received her M.D. in 1981 from the University of Missouri-Columbia. She completed residency training in internal medicine as well as subspecialty hematology and medical oncology training at the University of Iowa.

Dr. Burns has been a member of the faculty at the University of Minnesota since 1992. Her clinical interest is the treatment of malignant and nonmalignant hematologic disorders including lymphoma, leukemia, multiple myeloma, myelodysplasia, aplastic anemia, and blood and marrow transplantation. Her research interests focus on experimental therapy for malignant hematologic disorders including stem cell transplantation and immunotherapy, as well as complications of transplantation including infections, second cancers and late effects. As a member of the Training Committee of the American Society of Hematology, Dr. Burns has been active in the establishment of a Trainee Council. She also is the chair of a subcommittee to recommend new guidelines to the ACGME for hematology subspecialty training.

Selected Publications

MacMillan ML, Weisdorf DJ, Davies SM, DeFor TE, Burns LJ, Ramsay NK, Wagner JE, Blazar BR. Early antithymocyte globulin therapy improves survival in patients with steroid-resistant acute graft-versus-host disease.  Biol Blood Marrow Transplant 2002; 8:40-6.

Barker JN, Davies SM, DeFor TE, Burns LJ, McGlave PB, Miller JS, Weisdorf DJ. Determinants of survival after human leucocyte antigen-matched unrelated donor bone marrow transplantation in adults.  Br J Haematol 2002; 118:101-7.

Burns LJ, Miller W, Kandaswamy C, DeFor TE, MacMillan ML, Van Burik JA, Weisdorf DJ. Randomized clinical trial of ganciclovir vs acyclovir for prevention of cytomegalovirus antigenemia after allogeneic transplantation.  Bone Marrow Transplant 2002; 30:945-51.

Arora M, Burns LJ, Davies SM, Macmillan ML, Defor TE, Miller WJ, Weisdorf DJ. Chronic graft-versus-host disease: a prospective cohort study.  Biol Blood Marrow Transplant 2003; 9:38-45.

Lerner RE, Burns LJ. Transformed lymphoma: an Achilles' heel of non-Hodgkin's lymphoma.  Bone Marrow Transplant 2003; 31:531-7 (Review).

Burns LJ, Weisdorf DJ, DeFor TE, Vesole DH, Repka TL, Blazar BR, Burger SR, Panoskaltsis-Mortari A, Keever-Taylor CA, Zhang MJ, Miller JS. IL-2-based immunotherapy after autologous transplantation for lymphoma and breast cancer induces immune activation and cytokine release: a phase I/II trial.  Bone Marrow Transplant 2003; 32:177-86.  

Todd RF 3rd, Gitlin SD, Burns LJ; Committee On Training Programs. Subspeciality training in hematology and oncology, 2003: results of a survey of training program directors conducted by the American Society of Hematology.  Blood 2004; 103:4383-8.

Arora M, Burns LJ, Barker JN, Miller JS, Defor TE, Olujohungbe AB, Weisdorf DJ. Randomized comparison of granulocyte colony-stimulating factor versus granulocyte-macrophage colony-stimulating factor plus intensive chemotherapy for peripheral blood stem cell mobilization and autologous transplantation in multiple myeloma.  Biol Blood Marrow Transplant 2004; 10:395-404.

Majhail NS, Burns LJ. Hematopoietic stem cell transplantation in the treatment of peripheral T-cell lymphomas. Curr Hematol Rep. 2005; 4:252-9.

Vallera DA, Brechbiel MW, Burns LJ, Panoskaltsis-Mortari A, Dusenbery KE, Clohisy DR, Vitetta ES. Radioimmunotherapy of CD22-expressing Daudi tumors in nude mice with a 90Y-labeled anti-CD22 monoclonal antibody. Clin Cancer Res. 2005; 11:7920-8.

Majhail NS, Weisdorf DJ, Wagner JE, Defor TE, Brunstein CG, Burns LJ. Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphoma. Blood. 2006; 107:3804-7.

Rizzo JD, Wingard JR, Tichelli A, Lee SJ, Van Lint MT, Burns LJ, Davies SM, Ferrara JL, Socie G. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation: joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2006; 12:138-51.

Majhail NS, Lazarus HM, Burns LJ. Iron overload in hematopoietic cell transplantation. Bone Marrow Transplant. 2008; 41:997-1003.

Majhail NS, DeFor T, Lazarus HM, Burns LJ. High prevalence of iron overload in adult allogeneic hematopoietic cell transplant survivors. Biol Blood Marrow Transplant. 2008; 14:790-794.

Bunte MC, Patnaik MM, Pritzker MR, Burns LJ. Pulmonary veno-occlusive disease following hematopoietic stem cell transplantation: a rare model of endothelial dysfunction. Bone Marrow Transplant. 2008; 41:677-686.

Majhail NS, Flowers ME, Ness KK, Jagasia M, Carpenter PA, Arora M, Arai S, Johnston L, Martin PJ, Baker KS, Lee SJ, Burns LJ.. High prevalence of metabolic syndrome after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2009; 43:49-54. PMID: 18724397

Majhail NS, Lazarus HM, Burns LJ. Iron overload in hematopoietic cell transplantation. Bone Marrow Transplant. 2008; 41:997-1003.

Majhail NS, DeFor T, Lazarus HM, Burns LJ. High prevalence of iron overload in adult allogeneic hematopoietic cell transplant survivors. Biol Blood Marrow Transplant. 2008; 14:790-794.

Bunte MC, Patnaik MM, Pritzker MR, Burns LJ. Pulmonary veno-occlusive disease following hematopoietic stem cell transplantation: a rare model of endothelial dysfunction. Bone Marrow Transplant. 2008; 41:677-686.

Kumar P, Defor TE, Brunstein C, Barker JN, Wagner JE, Weisdorf DJ, Burns LJ. Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival. Biol Blood Marrow Transplant. 2008; 14:1394-400.

Al-Hazzouri A, Cao Q, Burns LJ, Weisdorf DJ, Majhail NS. Similar risks for hypothyroidism after allogeneic hematopoietic cell transplantation using TBI-based myeloablative and reduced-intensity conditioning regimens. Bone Marrow Transplant. 2008; [Epub ahead of print] PMID: 19104492

Burns LJ. Late effects after autologous hematopoietic cell transplantation. Biol Blood Marrow Transplant 2008; 15(1 Suppl):21-4. PMID: 19147072

Majhail NS, Defor TE, Lazarus HM, Burns LJ. Iron-overload after autologous hematopoietic cell transplantation. Leuk Res. 2009; 33:578-9. PMID: 18632150

Brunstein CG, Cantero S, Cao Q, Majhail N, McClune B, Burns LJ, Tomblyn M, Miller JS, Blazar BR, McGlave PB, Weisdorf DJ, Wagner JE. Promising progression-free survival for patients low and intermediate grade lymphoid malignancies after nonmyeloablative umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2009; 15:214-22. PMID: 19167681