Harry S. Jacob, M.D.

• Reed College
• MD Cum Laude Harvard Medical School
• Professor and Head, Division of Hematology 1968-1997
• President, American Society of Hematology, 1998-2000
• Fellow of AAAS
• Doctoris Honoris Causa of Hungary
• Honorary Fellow of the Royal College (England)

Selected Publications

Balla J, Vercellotti GM, Jeney V, Yachie A, Varga Z, Jacob HS, Eaton JW, Balla G. Heme, heme oxygenase, and ferritin: how the vascular endothelium survives (and dies) in an iron-rich environment. Antioxid Redox Signal 2007; 9:2119-37. Review.

Balla J, Balla G, Jeney V, Kakuk G, Jacob HS, Vercellotti GM. Ferriporphyrins and endothelium: a 2-edged sword-promotion of oxidation and induction of cytoprotectants. Blood. 2006; 95:3442-50. 

Ujhelyi L, Balla J, Muszbek L, Kakuk G, Belcher J, Jacob HS, Vercellotti GM, Balla G. A microassay to assess the oxidative resistance of low-density lipoproteins. Clin Chem. 1998; 44(8 Pt 1):1762-4. 

Kovacs A, Weber ML, Burns LJ, Jacob HS, Vercellotti GM. Cytoplasmic sequestration of p53 in cytomegalovirus-infected human endothelial cells. Am J Pathol. 1996; 149: 1531-9.

Jacob HS. Vascular shear-forces and atherogenesis: Roles of shear-provoked endothelial viral infection and heme iron accumulation. Perspectives in Biology and Medicine 1994; 38: 114-124.

Paller MS, Jacob HS. Cytochrome P-450 mediates tissue damaging hydroxyl radical formation during reoxygenation of the kidney. PNAS 1994; 91: 7002-7006.

Cermak J, Balla J, Jacob HS, et al . Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity: Possible role in chemotherapy efficacy. Cancer Research 1993; 53: 5308-5313.

Balla G, Jacob HS, Balla J et al . Ferritin: A cytoprotective antioxidant strategem of endothelium. J Biol Chem 1992; 267: 18148-18153.

Nath KA, Balla G, Balla J et al . Induction of heme oxygenase is a rapid, protective response in the crush syndrome. J Clin Invest 1992; 90: 267-270.