Philip McGlave, M.D

Area of Expertise: Stem cell biology; CML

Dr. McGlave is the Director of the Hematology, Oncology and Transplantation (HOT) Division and holds the Cecil J. Watson Land Grant Chair in the Department of Medicine. He is also the Associate Director of Experimental Therapeutics at the University of Minnesota Cancer Center.

Dr. McGlave received his M.D. in 1974 from the University of Illinois. He received internal medicine residency training and hematology subspecialty training at the University of Minnesota.  He also received training in bone marrow transplantation  as a Visiting Fellow at the Fred Hutchinson Cancer Research Center in Seattle, Washington.  Dr. McGlave founded the Adult Bone Marrow Transplant Program at the University of Minnesota.

Dr. McGlave’s clinical interest is the treatment of malignant and nonmalignant hematologic disorders including aplastic anemia, leukemia, lymphoma, multiple myeloma, myelodysplasia, and blood and marrow transplantation. His research interests focus on experimental therapy for malignant and non-malignant hematologic disorders including stem cell transplantation, immunotherapy, and gene transfer.

Selected Publications

Bhatia R, Verfaillie CM, Miller JS, McGlave PB.  Autologous transplantation therapy for chronic myelogenous leukemia.  Blood 1997; 89: 2623-2634.

McGlave P.  Unrelated donor transplantation therapy for CML in Hematology and Oncology Clinics of North America.  In: McGlave P. and Verfaillie C. (eds.).  Chronic Myelogenous Leukemia. W. B. Saunders 1998;12:  93-105.

Verfaillie CM, Bhatia R, Steinbuch M, DeFor T, Hirsch E, Miller JS, Weisdorf D, McGlave PB.  Comparative analysis of autografting in CML:  Effects of priming regimen and marrow or blood origin of stem cells.  Blood 1998; 92:  1820-1831.

McGlave P.  Overview of stem cell transplantation.  In: Hoffman, Benz, Jr., Shattil, Furie, Cohen, Silberstein, McGlave (eds.).  Hematology: Basic Principles and Practice, Third Edition. Churchill-Livingstone:  2000, p. 1550.

McGlave PB, Xiao OS, Wen W, Anasetti C, Nademanee A, Champlin R, Antin JH, Kernan NA, King R, Weisdorf DJ.  Unrelated donor marrow transplantation for chronic myelogenous leukemia: 9 years' experience of the National Marrow Donor Program.  Blood 2000; 95:  2219-2225.

Petersdorf EW, Kollman C, Hurley CK, Dupont B, Nademanee A, Begovich AB, Weisdorf D, McGlave P.  Effect of HLA class II gene disparity on clinical outcome in unrelated donor hematopoietic cell transplantation for CML:  the U.S. national marrow donor program experience.  Blood 2001; 98:  2922-2929.

Barker JN, Davies SM, DeFor TE, Burns LJ, McGlave PB, Miller JS, Weisdorf DJ.  Determinants of survival after human leucocyte antigen-matched unrelated donor bone marrow transplantation in adults.  British Journal of Haematology 2002; 118:101-107.

Weisdorf DJ, Anasetti C, Antin JH, Kernan NA, Kollman C, Snyder D, Petersdorf E, Nelson G, McGlave P.  Allogeneic bone marrow transplantation for chronic myelogenous leukemia: Comparative analysis of unrelated versus matched sibling donor transplantation.  Blood 2002; 99:1971-1977.

Anderson D, DeFor T, Burns L, McGlave P, Miller J, Wagner J, Weisdorf D.  A comparison of related donor peripheral blood and bone marrow transplants: Importance of late-onset chronic graft-versus-host disease and infections.  Biology of Blood and Marrow Transplantation 2003; 9:52-59.

Chiorean EG, DeFor TE, Weisdorf DJ, Blazar BR, McGlave PB, Burns LJ, Brown C, Miller JS. Donor chimerism does not predict response to donor lymphocyte infusion for relapsed chronic myelogenous leukemia after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2004; 10:171-7.

Baker KS, Gurney JG, Ness KK, Bhatia R, Forman SJ, Francisco L, McGlave PB, Robison LL, Snyder DS, Weisdorf DJ, Bhatia S. Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor Study. Blood 2004; 104:1898-906.

Bhatia R, McGlave PB. Autologous hematopoietic cell transplantation for chronic myelogenous leukemia. Hematol Oncol Clin North Am 2004; 18:715-32 (review).

Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, McGlave PB, Miller JS, Verfaillie CM, Wagner JE. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy.  Blood 2005; 105:1343-7.

Laudi N, Arora M, Burns LJ, Miller JS, McGlave PB, Barker JN, Ramsay NK, Orchard PJ, Macmillan ML, Weisdorf DJ. Long-term follow-up after autologous hematopoietic stem cell transplantation for low-grade non-Hodgkin lymphoma.  Biol Blood Marrow Transplant 2005; 11:129-35.

Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, Fautsch SK, McKenna D, Le C, Defor TE, Burns LJ, Orchard PJ, Blazar BR, Wagner JE, Slungaard A, Weisdorf DJ, Okazaki IJ, McGlave PB. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in cancer patients.  Blood 2005; 105:3051-7.

Bhatia S, Robison LL, Francisco L, Carter A, Liu Y, Grant M, Baker KS, Fung H, Gurney JG, McGlave PB, Nademanee A, Ramsay NK, Stein A, Weisdorf DJ, Forman SJ. Late mortality in survivors of autologous hematopoietic cell transplantation: report from the Bone Marrow Transplant Survivor Study.  Blood 2005; 105:4215-22.

Arora M, McGlave PB, Burns LJ, Miller JS, Barke JN, Defor TE, Weisdorf DJ.  Results of autologous and allogeneic hematopoietic cell transplant therapy for multiple myeloma.  Bone Marrow Transplant. 2005; 35:1133-40.

Majhail NS, Weisdorf DJ, Defor TE, Miller JS, McGlave PB, Slungaard A, Arora M, Ramsay NK, Orchard PJ, MacMillan ML, Burns LJ.  Long-term results of autologous stem cell transplantation for primary refractory or relapsed Hodgkin's lymphoma.  Biol Blood Marrow Transplant. 2006; 12:1065-72.

Carter A, Robison LL, Francisco L, Smith D, Grant M, Baker KS, Gurney JG, McGlave PB, Weisdorf DJ, Forman SJ, Bhatia S.  Prevalence of conception and pregnancy outcomes after hematopoietic cell transplantation: report from the Bone Marrow Transplant Survivor Study.  Bone Marrow Transplant. 2006; 37:1023-9.

McKenna DH Jr, Sumstad D, Bostrom N, Kadidlo DM, Fautsch S, McNearney S, Dewaard R, McGlave PB, Weisdorf DJ, Wagner JE, McCullough J, Miller JS.  Good manufacturing practices production of natural killer cells for immunotherapy: a six-year single-institution experience.  Transfusion. 2007; 47:520-8.

Jacobson P, Green K, Rogosheske J, Brunstein C, Ebeling B, DeFor T, McGlave P, Weisdorf D.  Highly variable mycophenolate mofetil bioavailability following nonmyeloablative hematopoietic cell transplantation.  J Clin Pharmacol. 2007; 47:6-12.

Brunstein CG, Barker JN, Weisdorf DJ, Defor TE, McKenna D, Chong SY, Miller JS, McGlave PB, Wagner JE. Intra-BM injection to enhance engraftment after myeloablative umbilical cord blood transplantation with two partially HLA-matched units. Bone Marrow Transplant. 2009 Jan 12. PMID: 19139736

Brunstein CG, Cantero S, Cao Q, Majhail N, McClune B, Burns LJ, Tomblyn M, Miller JS, Blazar BR, McGlave PB, Weisdorf DJ, Wagner JE. Promising progression-free survival for patients low and intermediate grade lymphoid malignancies after nonmyeloablative umbilical cord blood transplantation. Biol Blood Marrow Transplant. 2009; 15:214-22. PMID: 19167681

Arora M, Weisdorf DJ, Spellman SR, Haagenson MD, Klein JP, Hurley CK, Selby GB, Antin JH, Kernan NA, Kollman C, Nademanee A, McGlave P, Horowitz MM, Petersdorf EW. HLA-identical sibling compared with 8/8 matched and mismatched unrelated donor bone marrow transplant for chronic phase chronic myeloid leukemia. J Clin Oncol. 2009 Feb 17. [Epub ahead of print]