Arne Slungaard, M.D.

Area of Expertise: Research in inflammation

Dr. Slungaard is a Professor of Medicine. He received his B.A. from Carleton College, Northfield, Minnesota and his M.D., residency, and Hematology and Oncology subspecialty training at the University of Minnesota. He joined the faculty in 1984.

His clinical interest is in bone marrow and peripheral blood stem cell transplantation. His research interests are 1) the biology and pathology of eosinophil peroxidase-mediated oxidant tissue damage; and 2) interactions of cationic proteins such as platelet factor 4 with the thrombomodulin/ protein C natural anticoagulant system. He is the coordinator of Grand Rounds for the section of Hematology, Oncology, and Transplantation.

Selected Publications

AZ Dudek, CA Pennell, TD Decker, TA Young, NS Key, and Slungaard A.  Platelet factor 4 binds to glycanated forms of thrombomudulin and to protein C: Potential anticoagulant role in coagulation. Journal of Biological Chemistry  272: 31785-31792, 1997.

Arlandson M,  Decker T, Roongta V, Mayo K, Bonilla L, MacPherson JC, Hazen SL, and Slungaard A.  Eosinophil peroxidase oxidation of thiocyanate: characterization of major reaction products and a potential sulfhydryl-targeted cytotoxicity system. Journal of Biological Chemistry, 276:215-224, 2001.

Ozcan M, Morten CT, Solovey A, Dandelet L, Bach RR, Hebbel RH,  Slungaard A, and Key NS. Whole blood tissue factor procoagulant activity remains detectable during severe aplasia following bone marrow and peripheral blood transplantation. Thrombosis and Haemostasis,  85:250-5, 2001.

Toor AA, Slungaard A, Hedner U, Weisdorf DJ, and Key NS.  Acquired factor VII deficiency in bone marrow transplant recipients. Bone Marrow Transplantation, 29:403-408, 2002.

Albert CJ, Thukkani AK, Heuertz RM, Slungaard A, Hazen SL, and Ford DA.  Eosinophil Peroxidase-Derived Reactive Brominating SpeciesTarget the Vinyl Ether Bond of Plasmalogens Generating a Novel Chemotractant, a-Bromo Fatty Aldehyde.  Journal of Biogical Chemistry 278:8942-8950,  2003.

Dudek AZ,  Nesmelova I, Mayo K, Verfaillie CM, Pitchford S, De Moor K, and Slungaard A. Platelet Factor 4 (PF4) Promotes Adhesion of Hematopoietic Progenitor Cells and Binds IL-8: Novel Mechanisms for Modulation of Hematopoiesis.  Blood 101:4687-4694, 2003.

Slungaard A, Fernández JA, Griffin JH, Key NL, Long JR, Piegors DJ, and Lentz SR.  Platelet factor 4 enhances generation of activated protein C in vitro and in vivo. Blood 102:146-151, 2003.

Albert CJ, Thukkani AK, Heuertz RM, Slungaard A, Hazen SL, Ford DA. Eosinophil peroxidase-derived reactive brominating species target the vinyl ether bond of plasmalogens generating a novel chemoattractant, alpha-bromo fatty aldehyde.  J Biol Chem 278:8942-50, 2003.

Aras O, Shet A, Bach RR, Hysjulien JL, Slungaard A, Hebbel RP, Escolar G, Jilma B, Key NS. Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia.  Blood 103:4545-53, 2004.

Slungaard A. Platelet factor 4 modulation of the thrombomodulin-protein C system  (Review). Crit Care Med; 32 (5 Suppl):S331-5, 2004.

Xia YF, Ye BQ, Li YD, Wang JG, He XJ, Lin X, Yao X, Ma D, Slungaard A, Hebbel RP, Key NS, Geng JG.  Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. J Immunol 173:4207-17, 2004.

Nesmelova IV, Sham Y, Dudek AZ, van Eijk LI, Wu G, Slungaard A, Mortari F, Griffioen AW, Mayo KH. PF4 and IL8 CXC-chemokine heterodimer formation modulates function at the quarternary structural level.  J Biol Chem 2004; 280:4948-58.  

Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, Fautsch SK, McKenna D, Le C, Defor TE, Burns LJ, Orchard PJ, Blazar BR, Wagner JE, Slungaard A, Weisdorf DJ, Okazaki IJ, McGlave PB. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in cancer patients.  Blood 2005; 105: 3051-3057.

Slungaard A. Platelet factor 4: a chemokine enigma. Int J Biochem Cell Biol 2005; 37:1162-7.

Nesmelova IV, Sham Y, Dudek AZ, van Eijk LI, Wu G, Slungaard A, Mortari F, Griffioen AW, Mayo KH. Platelet factor 4 and interleukin-8 CXC chemokine heterodimer formation modulates function at the quaternary structural level. J Biol Chem 2005; 280: 4948-58.

Tan PL, Wagner JE, Auerbach AD, Defor TE, Slungaard A, Macmillan ML. Successful engraftment without radiation after fludarabine-based regimen in Fanconi anemia patients undergoing genotypically identical donor hematopoietic cell transplantation. Pediatr Blood Cancer 2006; 46: 630-6.

Wang JG, Mahmud SA, Thompson JA, Geng JG, Key NS, Slungaard A. The principal eosinophil peroxidase product, HOSCN, is a uniquely potent phagocyte oxidant inducer of endothelial cell tissue factor activity: a potential mechanism for thrombosis in eosinophilic inflammatory states. Blood 2006; 107: 558-65.

Wang J, Slungaard A. Role of eosinophil peroxidase in host defense and disease pathology.  Arch Biochem Biophys 2006; 445: 256-60. (review).

Li YD, Ye BQ, Zheng SX, Wang JT, Wang JG, Chen M, Liu JG, Pei XH, Wang LJ, Lin ZX, Gupta K, Mackman N, Slungaard A, Key NS, Geng JG. NF-kappa B transcription factor p50 critically regulates tissue factor in deep vein thrombosis. J Biol Chem. 2008 Dec 18; [Epub ahead of print]