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Home > Faculty > Research Faculty > Lokensgard, James
Lokensgard, James
 James Lokensgard, Ph.D. obtained an M.S. degree from North Dakota State University, a Ph.D. degree from the University of Minnesota, and received post-doctoral training at the University of California Los Angeles. Dr. Lokensgard's laboratory currently performs studies supporting two independent research programs in neurovirology. The first program investigates host defense mechanisms against cytomegalovirus brain infection. Our experiments investigate how glial cell-produced chemokines recruit peripheral lymphocytes into the brain to control intracerebral spread of MCMV. The Laboratory's other program studies the immunoregulation of herpes simplex virus (HSV) encephalitis by microglial cells. We are investigating how chemokines produced by microglial cells in response to HSV infection initiate cascades of neuroimmune responses that result in the serious brain damage seen during herpes encephalitis. Knowledge gained from these studies will increase our understanding of the role of chemokine networks in regulating brain inflammation with the ultimate goal of finding new therapy for serious viral brain infections.
Selected Publications:
Lokensgard JR, Cheeran MC-J, Hu S, Gekker G, and Peterson PK. Glial cell responses to herpesvirus infections: role in defense and pathogenesis. J Infect Dis. 2002;186 (Suppl 2):S171-S179.
Lokensgard JR, Gekker G, Peterson PK. k-Opioid receptor agonist inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion and CXCR4 expression on CD4+ lymphocytes. Biochem Pharmacol. 2002;63:1037-1041.
Cheeran MC-J, Hu S, Sheng WS, Peterson PK, Lokensgard JR. CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10. J Virol. 2003;77:4502-4515.
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