Perry Hackett, Ph.D.

Professor
Developmental Biology and Genetics
Department of Genetics, Cell Biology and Development
University of Minnesota
1445 Gortner Avenue
St. Paul, MN 55108-1095
Phone: (612) 624-6736
Fax: (612) 625-5754
e-mail: perry@cbs.umn.edu website

Lab Photos

1. Sleeping Beauty-Mediated Gene Therapy

Website

http://biosci.cbs.umn.edu/labs/perry/

Recent Publications

• Wilber, A., J.L. Frandsen, A.M. Geurts, D.A. Largaespada, P.B. Hackett, and R.S. McIvor (2006). RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues. Mol Ter. 13: 625-630.
• Geurts*, A.M., C.S. Hackett*, J.B. Bell, T.L. Bergemann, C.M. Carlson, L.S. Collier, D.A. Largaespada and P.B. Hackett (2006). Structure-based prediction of insertion-site preferences of transposons into chromatin. Nucl. Acids Res. 34: 2803-2811.
• Geurts, A.M., A.C. Wilber, C.M. Carlson, P.D. Lobitz, K.J. Clark, P.,B. Hackett, R.S. McIvor, D.A. Largaespads (2006). Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. BMC Biotech 6(1): 30.
• Balciunas, D., K.J. Wagensteen, A.C. Wilber, J.B. Bell, A.M. Geurts, S. Sivasubbu, X. Wang, P.B. Hackett, D.A. Largaespada, R.S. McIvor, and S.C. Ekker (2006). Harnessing an efficient large cargo-capacity transposon for vertebrate gene transfer applications. PLoS Genetics. 4: e169.
• Hackett, P.B. (2007). Integrating DNA vectors for gene therapy. Mol. Ther. 15: 10-12.
• Aronovich, E.L., J.B. Bell, L.R. Belur, R. Gunther, B. Koniar, D.C. Erickson, P.A. Schachern, R.S. McIvor, C.B. Whitley and P.B. Hackett (2007). Sleeping Beauty transposon-mediated gene therapy of murine mucopolysaccharidosis. J. Gene Med. 9: 403-415.
• Hackett, C.S., A.M. Geurts and P.B. Hackett (2007). Predicting DNA vector insertion sites: Implications for functional genomics and gene therapy. Genome Biol. 8 (Suppl 1): S12.
• Bell, J.B., K. Podetz-Pedersen, E.L. Aronovich, L. Belur, R.S. McIvor and P.B. Hackett (2007). Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nature Protocols 2 (12): 3153-3165.