Scott McIvor, Ph.D.

Professor and Director, Gene Therapy Program
Institute of Human Genetics
Department of Genetics, Cell Biology and Development
Dept of Laboratory Medicine and Pathology
Phone: (612) 626-1497
Fax: (612) 625-9810
e-mail: mcivor@med.umn.edu

Research Interests

The general research interest of Dr. McIvor's laboratory is gene therapy for genetic diseases and cancer. Specific research activities include: (i) Use of recombinant retroviral vectors for gene transfer into hematopoietic stem cells in the treatment of cancer and inherited disorders such as immunodeficiency diseases and lysosomal storage diseases; (ii) Introduction of drug-resistance genes into normal hematopoietic cells to protect against the toxic side effects of cancer chemotherapy; (iii) Use of adeno-associated virus for treatment of storage diseases and as a vector for gene transfer into the central nervous system in the treatment of neurological disorders; (iv) Adaptation of a novel vertebrate transposon ("Sleeping Beauty") to viral and non-viral delivery systems for gene therapy.

Recent Publications

Sweeney, C.L., J.L. Frandsen, C.M. Verfaillie and R.S. McIvor. 2003. Trimetrexate inhibits progression of the murine 32Dp210 model of chronic myeloid leukemia in animals expressing drug-resistant dihydrofolate reductase. Cancer Research 63:1304-10.

Belur, L., J.L. Frandsen, A. Dupuy, D.H. Ingbar, D.L. Largaespada, P.B. Hackett and R.S. McIvor. 2003. Integration and long-term expression in lung mediated by the Sleeping Beauty transposon system. Molecular Therapy 8: 501-507.

Hartung, S.D., J.S. Frandsen, D. Pan, B. Koniar, P. Graupman, R. Gunther, W.C. Low, C.B. Whitley and R. S. McIvor. 2004. Correction of metabolic, neurologic, and craniofacial abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human ?-L-iduronidase gene. Molecular Therapy, 9: 866-875.