Jianyi "Jay" Zhang, MD, PhD - Lab

The Laboratory of Cardiac Energetics and Cellular Therapy for Heart Failure  An NIH funded lab dedicated to the discovery of new therapies to protect & restore cardiovascular health
	Our Lab
	Current Research
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	Lab Links
	Quick Contact: Lab Manager: Lei Ye KE Labs: 612-625-4699 Dr. Zhang: 612.625.7403 FAX:612.626.4411 Lab: 612.625.1644 Email: zhang047@umn.edu Laura Scavellaio (Secretary): 612-624-8970

Principal Investigator:
	Dr. Jianyi (Jay) Zhang. M.D. Ph.D. "Lets work together to solve problems that are the of the utmost importance"

Current Research. Click for more!

•Stem Cell Therapy and Post-infarction Remodeling
•Myocardial Bioenergetics in Failing Hearts
•A 3D Porus PEGylated Fibrin Scaffold for Enhanced Delivery of Stem Cells in Hearts with Myocardial Infarction

Recent Publications

1. Xiong Q, Du F, Zhang P, Chen W, Zhang J. ATP production rate via CK or ATP synthase in vivo: a novel superfast magnetization saturation transfer method . Circulation Research (in press 2011)

2. Xiong Q, Hill, K, Li Q, Suntharalingam P, Mansoor A, Jameel MN, Wang X, Zhang J. A fibrin patch-based enhanced delivery of human embryonic stem cell-derived vascular cell transplantation in a porcine model of postinfarction LV remodeling. Stem Cells. 2010 Dec 23. [Epub ahead of print]

3. Jameel MN, Mansoor A, Qiang X, Li Q, Swingen C , Zhang J . Long term preservation of myocardial energetic in chronic hibernating myocardium. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1348-56. Epub 2010 Feb 19.

4. Jameel MN, Li Q, Mansoor A, Qiang X, Sarver A, Wang X, Swingen C , Zhang J . Long term functional improvement and gene expression changes after bone marrow derived multipotent progenitor cell transplantation in myocardial infarction. Am J Physiol Heart Circ Physiol (February, 2010). PMID: 20173039. PMC Journal – In Press.

5. Xiong Q, Li Q, Mansoor A, Jameel MN, Du F, Chen W, Zhang J. Novel strategy for measuring creatine kinase reaction rate in the in vivo heart. Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1010-9. Epub 2009 Jun 26

6. Wang X, Jameel MN, Li Q, Mansoor A, Xiong Q, Swingen C, Panetta Zhang J. Stem Cells for Myocardial Repair Using a Trans-Arterial Catheter. Circulation. 2009 Sep 15;120(11 Suppl):S238-46

7 .Wu F, Zhang J, Beard DA. Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7143-8.

8. Jameel MN, Wang X, Eijgelshoven MH, Mansoor A, Zhang J. Transmural distribution of metabolic abnormalities and glycolytic activity during dobutamine-induced demand ischemia. Am J Physiol Heart Circ Physiol. 2008, Jun;294(6):H2680-6.

9. Wu F, Zhang EY, Zhang J, Bache RJ, Beard DA. Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischemic hearts. J Physiol. 2008 Sep 1;586 (Pt 17):4193-208

10. Zhang G, Hu Q, Braunlin EA, Suggs LJ, Zhang J. Enhancing efficacy of stem cell transplantation to the heart with a PEGylated fibrin biomatrix. Tissue Eng Part A. 2008 May 14.

11. Feygin J, Hu Q, Swingen C, Zhang J. Relationships between regional myocardial wall stress and bioenergetics in hearts with left ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2008 May, 294(5):H2313-21.

12. McFalls EO, Kelly RF, Hu Q, Mansoor A, Lee J, Kuskowski M, Sikora J, Ward HB, Zhang J. The energetic state within hibernating myocardium is normal during dobutamine despite inhibition of ATP-dependent potassium channel opening with glibenclamide. Am J Physiol Heart Circ Physiol. 2007, Nov;293(5):H2945-51.

13. Feygin J, Mansoor A, Eckman P, Swingen C, Zhang J. Functional and bioenergetic modulations in the infarct border zone following autologous mesenchymal stem cell transplantation. Am J Physiol Heart Circ Physiol. 2007, 293(3):H1772-80.

14. Zeng L, Hu Q, Wang X, Mansoor A, Lee J, Feygin J, Amhashilkar A, Deans R, Verfaillie C, Zhang J. Bioenergetic and functional consequences of transplantation multipotent progenitor cells in hearts with post-infarction LV remodeling. Circulation. 2007 Apr 10;115(14):1866-75. Epub 2007 Mar 26.

15. PelachoB, Nakamura Y, Zhang J, Ross J, Heremans Y, Nelson-Holte M, Brad Lemke B, Hagenbrock J, Jiang J, Luttun A, Verfaillie C. Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction. Journal of Tissue Engineering and Regenerative Medicine (in press, 2007).

16. Tolar J, Wang X, Nakamura Y, Zhang J, Blazer BR. Cardiomyoplasty with multipotent adult progenitor cells after ischemic injury in immunocompetent and immunodeficient mice. Exp Hematol. 2007 Apr;35(4):682-90.

17. Nakamura Y, Wang X, Xu C, Yoshiyama M, Zhang J. Swine bone marrow-derived mesenchymal stem cells in immuno-deficient mice with induced-acute myocardial infarction (AMI). Stem Cells. 2007 Mar;25(3):612-20.

18. Zhang G, Nakamura Y, Wang X, Hu Q, Suggs L, Zhang J. Controlled release of stromal cell derived. Factor-1a in situ increases stem cell homing to the infarcted heart. Tissue Eng. 2007 Feb 22; [Epub ahead of print].

19. Hu Q, Wang X, Lee J, Mansoor A, Wang Z, From AH, Bache, RJ, Zhang J. Profound bioenergetic abnormalities in peri-infarct myocardial regions. Am J Physiol Heart Circ Physiol; 2007, 291(2):H648-57.

20. Zeng L, Rahrmann E, Hu Q, Zhang J, Verfaillie C. Multi-potent adult progenitor cells from swine bone marrow. Stem Cells. 2006 Nov;24(11):2355-66. Epub 2006 Aug 24.

21. Lee J, Hu Q, Nakamura Y, Wang Z, Chen W, QL Yong, Zhang J . Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 Tesla.? JMRI 2006 (in press).

22. Ochiai K, Hu Q, Lee J, Mansoor A, Liu J, Wang X, Gong G, Murakami Y, Ishibashi Y, Shimada T,? Zhang J . Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling. Journal of Cardiovascular Pharmacology 2006; 47 (5): 686-694.

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