Terence C. Burns

Year entered: 2001

Degrees Received: 
B.S. Biology and Biochemistry, Columbia Union College, 2001
Ph.D., Neuroscience Graduate Program, 2007

Honors:
Alpha Omega Alpha Honor Medical Society, 2008
Kappa Phi Kappa Graduate student Honor society, 2007
Selected to participate in Route28 Summit in Neurobiology, Germany, 2007
Doctoral Dissertation Fellowship, University of Minnesota, 2006-2007
American Society for Neural Therapy and Repair Travel Award, 2006
Hough Parkinson’s Grant Recipient, 2005-2006
Society For Neuroscience Predoctoral Travel Award, 2005
Chancellor's List  (Who's Who Among Graduate Students, 2004 and 2005
BMEI Tissue Engineering Fellowship, 2004-2005
Smithberg Memorial Prize for outstanding performance by a first-year neuroscience graduate student, 2004
3M Science and Technology Fellowhip, 2003-2007
Honors - Years 1 and 2, Medical School

Thesis Advisors: Catherine Verfaillie, M.D., Department of Medicine and Walter Low, Ph.D., Neuroscience Graduate Program

Thesis Research: 

My PhD thesis was entitled "Stem Cells and Ischemic Brain Injury." This multifaceted work investigated in vitro stem cell differentiation techniques, the in vivo behavior of stem cells transplanted into normal and ischemic brain and techniques for specific labeling of transplanted as well as endogenous stem cells. Findings included 1) the previously unappreciated transfer of thymidine analogue labels from transplanted donor cells to dividing host cells after transplantation, 2) en masse migration of GFP-labeled transplanted multipotent adult progenitor cells from the graft to the infarct site, 3) rare appearance of GFP-labeled neuronal cells in the graft periphery, and 4) tumor formation from cytogenetically normal adult stem cells at long time-points. Additional preliminary work was also begun to develop and refine techniques for specific prospective labeling of endogenous neural stem cells.

Publications:

Michaeli S, Burns TC, Kudishevich E,Hanson T, Sorce DJ, Garwood M, Low WC.  Detection of neuronal loss using T1_ñ MRI assessment of  ¹H₂O spin dynamics in the aphakia mouse model. J Neurosci Methods, in press.

Burns TC, Rodriguez GJ, Patel S, Hussein HM, Georgiadis AL, Lakshminarayan K, Qureshi AI. Endovascular interventions following intravenous thrombolysis may improve survival and recovery in patients with acute ischemic stroke: A case control study. Am J Neuroradiol. 2008. [Epub ahead of print.]

Burns TC, Low WC, Verfaillie CM. From neural stem cells to neuroregeneration. In: Stem Cells and Regenerative Medicine. Eds.: Catherine M. Verfaillie and Walter C. Low. 2008 World Scientific Publishing, Co., 2008, p. 291-326.

Hajdu M, Luttun A, Pelacho B, Burns TC, Chase L, Gutiérrez-Pérez M, Jiang Y, Lenvik T, Vas V, Uher F, Sebestyén A, Verfaillie C. Transcriptional characterization of the Notch signaling pathway in rodent multipotent adult progenitor cells. Pathol Oncol Res. 2007;13:302-310

Naylor MC, Negia M, Noetzel M, Burns TC, Demorest ZL, Low WC. Heparan sulfate mediates neuroprotection from degeneration in experimental glutaric aciduria. Cell Transplant. 2007;16:187-195.

Serafini M, Dylla SJ, Oki M, Heremans Y, Tolar J, Jiang Y, Buckley SM, Pelacho B, Burns TC, Frommer S, Rossi DJ, Bryder D, Panoskaltsis-Mortari A, O'Shaughnessy MJ, Nelson-Holte M, Fine GC, Weissman IL, Blazar BR, Verfaillie CM. Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells. J Exp Med. 2007;204:129-139.

Burns TC, Ortiz-Gonzalez XR, Gutierrez-Perez M, Keene CD, Sharda R, Demorest ZL, Jiang Y, Nelson-Holte M, Soriano M, Nakagawa Y, Luquin MR, Garcia-Verdugo JM, Prosper F, Low WC, Verfaillie CM. Thymidine analogs are transferred from pre-labeled donor to host cells in the central nervous system after transplantation: A word of caution. Stem Cells 2006;24:1121-1127.