E-mail: hata0006@umn.edu
Year entered: 2001
Degrees Received:
B.S., Chemistry, University of California-Berkeley, 1996
Ph.D., Microbiology, Immunology & Cancer Biology, 2006
M.D., University of Minnnesota Medical School, 2008
Honors and Awards:
Honors, Years 1 and 2, Medical School
Medical Alley Scholarship-Minnesota Medical Foundation, 2001
Immunology Training Grant predoctoral fellowship, 2002-2004
Veneziale-Steer Award for outstanding student research in the field of cellular growth regulation, Minnesota Medical Foundation, 2007
Thesis Advisor: Marc Jenkins, Ph.D., Microbiology, Immunology and Cancer Biology Graduate Program
Thesis Research:
I'm interested in understanding how immunity to infectious diseases is generated and maintained. In Marc Jenkins's lab, we study CD4 T cells, which provide "help" in the form of molecular signals to other immune system cells that directly eliminate pathogens. My thesis project is aimed at understanding the factors that contribute to the long-term survival of memory T cells.
Publications:
Catron DM, Rusch LK, Hataye J, Itano AA, Jenkins MK. CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells J Exp Med. 2006 ;203:1045-1054.
Hataye J, Moon JJ, Khoruts A, Reilly C, Jenkins MK. Naïve and memory CD4+ T cell survival controlled by clonal abundance. Science. 2006;312:114-116.
Prior to PhD Phase of Program
Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J Mol Biol. 2001;307:1451-86.
Verner E, Katz BA, Spencer JR, Allen D, Hataye J, Hruzewicz W, Hui HC, Kolesnikov A, Li Y, Luong C, Martelli A, Radika K, Rai R, She M, Shrader W, Sprengeler PA, Trapp S, Wang J, Young WB, Mackman RL. Development of serine protease inhibitors displaying amulticentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa. J Med Chem. 2001;44:2753-71.
Sperandio D, Gangloff AR, Litvak J, Goldsmith R, Hataye JM, Wang VR, Shelton EJ, Elrod K, Janc JW, Clark JM, Rice K, Weinheimer S, Yeung KS, Meanwell NA, Hernandez D, Staab AJ, Venables BL, Spencer JR. Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease. Bioorg Med Chem Lett. 2002;12:3129-33.
Sherman MP, De Noronha CM, Eckstein LA, Hataye J, Mundt P, Williams SA, Neidleman JA, Goldsmith MA, Greene WC. Nuclear export of vpr is required for efficient replication of human immunodeficiency virus type 1 in tissue macrophages. J Virol.2003 Jul;77:7582-9.
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