Joseph Lee

Year Entered: 2000

Degrees Received:
B.S., Chemical Engineering, Cornell University, 2000
Ph.D., Biomedical Engineering, University of Minnesota, 2006
M.D., University of Minnesota Medical School, 2008

Honors and Awards:
American Heart Association Predoctoral Fellowship, 2004-2006
Minnesota Medical Alley Scholarship in Biomedical Engineering, 2001
NIH Intramural Research Training Award, 1997

Thesis Advisors: Jianyi (Jay) Zhang, MD, PhD, Biomedical Engineering Graduate Program

Thesis Research:

I am working with Jay Zhang MD PhD in the area of myocardial bioenergetics. The Zhang group seeks to understand the heart in a variety of disease states and theraeutic scenarios (e.g., emerging stem cell treatments and pharmaceuticals). We perform our studies in teams on live model systems and employ a combination of techniques used in the specialties of cardiology, radiology, surgery and pathology.

Publications:

McFalls EO, Kelly RF, Hu Q, Mansoor A, Lee J, Kuskowski M, Sikora J, Ward HB, Zhang J. The energetic state within hibernating myocardium is normal during dobutamine despite inhibition of ATP-dependent potassium channel opening with glibenclamide. Am J Physiol Heart Circ Physiol. 2007;293:H2945-2951.

Lee J, Hu Q, Nakamura Y, Wang X, Zhang X, Zhu X, Chen W, Yang Q, Zhang J. Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 Tesla. J Magn Reson Imaging. 2006,24:1269-1276.

Ochiai K, Hu Q, Lee J, Mansoor A, Liu J, Wang X, Gong G, Murakami Y, Ishibashi Y, Shimada T, Zhang J. Functional and bioenergetic consequences of AT1 antagonist olmesartan medoxomil in hearts with postinfarction LV remodeling. J Cardiovasc Pharmacol. 2006;47:686-694.

Wang X, Hu Q, Nakamura Y, Lee J, Zhang G, From AH, Zhang J. The role of the Sca-1+/CD31- cardiac progenitor cell population in postinfarction left ventricular remodeling. Stem Cells. 2006;24:1779-1788.

Hu Q, Wang X, Lee J, Mansoor A, Liu J, Zeng L, Swingen C, Zhang G, Feygin J, Ochiai K, Bransford TL, From AH, Bache RJ, Zhang J. Profound bioenergetic abnormalities in peri-infarct myocardial regions. Am J Physiol Heart Circ Physiol. 2006;291:H648-657.

Wang X, Hu Q, Mansoor A, Lee J, Wang Z, Lee J, From AH, Zhang J. Bioenergetic and functional consequences of stem cell-based VEGF delivery in pressure-overloaded swine hearts. Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1393-405.

Lee J, Asakura A, Zhang J: Chapter 31: Experimental cell transplantation for myocardial repair. Handbook of Cardiac Anatomy, Physiology and Devices for the Biomedical Engineer. Iaizzo P, Totowa NJ (eds.). Humana Press, 2005, pp 427-438.

Zhang J, Gong G, Ye Y, Guo T, Mansoor A, Hu Q, Ochiai K, Liu J, Wang X, Cheng Y, Iverson N, Lee J, From AH, Ugurbil K, Bache RJ. Nitric oxide regulation of myocardial O2 consumption and HEP metabolism. Am J Physiol Heart Circ Physiol. 2005;288:H310-H316.

Liu J, Hu Q, Wang Z, Xu C, Wang X, Gong G, Mansoor A, Lee J, Hou M, Zeng L, Zhang JR, Jerosch-Herold M, Guo T, Bache RJ, Zhang J. Autologous stem cell transplantation for myocardial repair. Am J Physiol Heart Circ Physiol. 2004;287:H501-H511.