Selected Publications

JOURNAL ARTICLES

Jean WC, KeeneCD, Haines SJ (1998). Cervical arachnoid cysts after craniocervical decompression for Chiari II malformations: Report of three cases. Neurosurgery 43:941-945. Abstract (HTML) Full Text (PDF)

Rodrigues CMP, Linehan-Stieers CL, Keene CD, Ma X, Kren BT, Low WC, Steer CJ (2000). Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition. J. Neurochem.75: 2368-2379. Abstract (HTML) Full Text (PDF)

Tkac I, Keene CD, Pfeuffer J, Low WC, Gruetter R. (2001). Metabolic changes in quinolinic acid-lesioned rat striatum detected non-invasively by in vivo 1H NMR spectroscopy. J. Neurosci. Res. 66: 891-898. Abstract (HTML) Full Text (PDF)

Keene CD, Rodrigues CMP, Eich T, Linehan-Stieers C, Abt A, Kren BT, Steer CJ, Low WC (2001). A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington’s disease. Exp. Neurol. 171:351-360. Abstract (HTML) Full Text (PDF)

Zhao L-R, Duan W-M, Reyes M, Keene CD, Nussbaum ES, Verfaillie CM, and Low WC (2002). Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats. Exp. Neurol. 174: 11-20. Abstract (HTML) Full Text (PDF)

Keene CD, Rodrigues CMP, Eich T, Chhabra MS, Steer CJ, and Low WC (2002). Taurousedeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington’s disease. Proc. Natl. Acad. Sci. U S A 99: 10671-10676. Abstract (HTML) Full Text (PDF)

Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM. (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418: 41-49 Abstract (HTML) Full Text (PDF)

Keene CD, Ortiz-Gonzalez XR, Jiang Y, Largaespada DA, Verfaillie CM, and Low WC (2003) Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos. Cell Transplant.12: 201-213. Abstract (HTML) Full Text (PDF)

ABSTRACTS

Jansen EM, KeeneCD, Low WC. Pretreatment with antisense oligodeoxynucleotides against mRNA to the NMDA glutamate receptor is neuroprotective in a rodent model of neonatal ischemic-hypoxia: Behavioral and morphometric analyses. Society for Neuroscience Annual Meeting, Washington, D.C. November, 1996.

Jansen EM, KeeneCD, Low WC. Neuroprotection with antisense to the NR1 subunit of the NMDA receptor in a rodent model of neonatal ischemic-hypoxia.  19^th Annual Midwest Neurobiology Meeting, Minneapolis. April, 1997.

Keene CD, Jansen EM, Low WC. Effects of intraventricular injection of antisense oligodeoxynucleotides on NR1 protein production in neonatal rat brain. Society for Neuroscience Annual Meeting, New Orleans. November, 1997.

Jansen EM, Keene CD, Low WC. Pretreatment with antisense oligonucleotides against mRNA to the NMDA receptor is neuroprotective in a rat model of neonatal ischemic-hypoxia: TTC staining. Society for Neuroscience Annual Meeting, New Orleans. November, 1997.  

Tkac I, Pfeuffer J, Keene CD, Low WC, Gruetter R (1998). Metabolic changes in quinolinic acid-lesioned rat striatum studied by ¹H NMR spectroscopy. Magnetic Resonance Materials in Physics, Biol Med. 6:110.

  Keene CD, Jean WC, Spellman SR, Chiang L, Low WC. Increased expression of E2F-1 during cerebral ischemia-reperfusion injury may have role in apoptotic cell death. Annual Meeting of the Congress of Neurological Surgeons, Seattle. October, 1998.

Keene CD, Tkac I, Pfeuffer J, Gruetter R, Low WC. Proton magnetic resonance spectroscopic identification of alterations in the neurochemical profile of the rat striatum following quinolinic acid lesions. Society for Neuroscience Annual Meeting, Los Angeles. November, 1998.

Keene CD. Proton Magnetic Resonance Spectroscopic Identification of Neurochemical Alterations in a Rodent Model of Huntington’s Disease. 1999 Minnesota/Iowa Depts. of Neurosurgery Annual Meeting, Iowa City, IA

Keene CD,Eich TK, Low WC. Transplantation of MHC I and/or MHC II deficient mouse lateral ganglionic eminence into rat striatum. Society for Neuroscience Annual Meeting, Miami. November, 1999.

Keene CD, Reyes M, Zhao L-R, Wang W-J, Spellman SR, Verfaillie, CM, and Low WC. Phenotypic expression of transplanted human bone marrow-derived multipotent adult stem cells into the rat CNS. American Society for Neural Transplantation Annual Meeting, Clearwater, FL. April, 2000.

Zhao L-R, Duan W-M, Keene CD, Reyes M, Nussbaum ES, Verfaillie CM, Low, WC. Transplanted human bone marrow-derived adult stem cells survive and improve functional outcome in a rat model of cortical ischemic brain injury. American Society for Neural Transplantation Annual Meeting, Clearwater, FL. April, 2000.

Keene CD. From Bone to Brain: Neural differentiation of bone marrow-derived multipotent adult stem cells. 2000 Minnesota/Iowa Depts. of Neurosurgery Annual Meeting, Minneapolis, MN.

Reyes M, Keene CD, Low WC, Verfaillie CM.  Ex vivodifferentiation of mesenchymal stem cells into oligodendrocytes, astrocytes, and/or dopaminergic, gamma-amino-butyric-acid-ergic, or serotoninergic neurons.  Society for Neuroscience Annual Meeting, New Orleans.  November, 2000.

Zhao L-R, Duan W-M, Reyes M, Keene CD, Nussbaum ES, Verfaillie CM, Low WC. Human bone marrow stem cells exhibit neural phenotypes after transplantation and ameliorate neurological deficits with ischemic brain injury in rats.  Society for Neuroscience Annual Meeting, New Orleans.  November, 2000.

Keene CD, Reyes M, Zhao L-R, Wang W, Spellman SR, Verfaillie CM, Low WC. Transplantation of bone marrow-derived multipotent adult stem cells into the rat CNS: Phenotypic expression. Society for Neuroscience Annual Meeting, New Orleans. November, 2000.

Keene CD, Rodrigues CMP, Eich T, Linehan-Stieers C, Abt A, Kren BT, Steer CJ, Low WC.  A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington’s disease. American Society for Neural Transplantation Annual Meeting, Clearwater, FL. May, 2001.

Keene CD, Rodrigues CMP, Eich T, Linehan-Stieers C, Abt A, Kren BT, Steer CJ, Low WC. Bile acids for the brain?  Neuroprotective effects of tauroursodeoxycholic acid in experimental Huntington’s disease. 2001 Minnesota/Iowa Depts. of Neurosurgery Annual Meeting, Iowa City, IA.

Keene CD, Rodrigues CMP, Eich T, Linehan-Stieers C, Abt A, Kren BT, Steer CJ, Low WC. Neuroprotective effects of TUDCA, a hydrophilic bile acid, in experimental Huntington’s disease. Society for Neuroscience Annual Meeting, San Diego. November, 2001.

Verfaillie CM, Reyes M, Qi H, Aguilar D, Lenvick T, Lund T, Keene CD, Low WC. Multipotent bone marrow derived progenitor cells. Keystone Symposia, Keystone, CO. March, 2002.

Keene CD, Jiang Y, Ortiz-Gonzalez X, Chabbra MS, Largaespada DA, Verfaillie CM, and Low WC. Neural differentiation and incorporation of bone marrow-derived multipotent adult progenitor cells after single cell transplantation into blastocyst stage mouse embryos. International Society for Neural Transplantation and Repair, Keystone, CO. June, 2002.

BOOK CHAPTERS

Low WC, Duan W-M, Keene CD, Ni H-T, and Westerman MA (1999). Immunobiology of neural xenotransplantation, in Neuromethods, Vol 36: Neural Transplantation Methods (Dunnett, S.B, Boulton, A.A., and Baker, G.B., eds.), Humana Press, Totowa, NJ, pp. 503-41.