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Levi Downs, M.D., M.S., F.A.C.O.G.
 downs008@umn.edu
612-626-3111, office
Dr. Downs' clinical profile
(University of Minnesota Physicians Web site) Dr. Downs is an Assistant Professor in the Department of Obstetrics, Gynecology and Women’s Health and is the Interim Director of the Division of Gynecologic Oncology. In addition, Dr. Downs is the Clinical Care Co-Director of the Deborah. E. Powell Center for Women's Health, A Nationally Designated Center of Excellence and is the Program Co-leader of the Women's Cancer Research Program. Dr. Downs is a board certified gynecologic oncologist. Dr. Downs received his medical degree in 1994 from the University of Pittsburgh School of Medicine and completed an obstetrics and gynecology internship and residency at the Magee-Women’s Hospital of the University of Pittsburgh Medical Center. He completed a gynecologic oncology fellowship at the University of Minnesota. Dr. Downs’ research interests include HPV induced carcinogenesis, molecular therapeutics for cervical cancer and gynecologic oncology clinical trials. Thank you to Turner Biosystems Luminometer Grants Program for their generous donation of a luminometer: http://www.luminometer.org Selected Publications Downs LS Jr, Lima PH, Bliss RL, Blomquist CH. Cathepsins B and D activity and activity ratios in normal ovaries, benign ovarian neoplasms, and epithelial ovarian cancer. J Soc Gynecol Investig. 2005;12(7):539-44. Jonson AL, Bliss RL, Truskinovsky A, Judson P, Argenta P, Carson L, Dusenbery K, Downs LS Jr. Clinical features and outcomes of uterine and ovarian carcinosarcoma. Gynecol Oncol. 2006;100(3):561-4. Chura JC, Brooker D, Downs LS Jr. Adenocarcinoma of the urinary bladder presenting as locally advanced endometrial carcinoma. Case report and review of the literature. Gynecol Oncol. 2006;103(1):336-41. Argenta PA, Ghebre R, Dusenbery KE, Chen MD, Judson PL, Downs LS Jr, Carson LF. Radiation therapy with concomitant and adjuvant cisplatin and paclitaxel in high-risk cervical cancer: Long-term follow-up. Eur J Gynaecol Oncol. 2006;27(3):231-5. Chura JC, Truskinovsky AM, Judson PL, Johnson L, Geller MA, Downs LS Jr. Positron emission tomography and leiomyomas: Clinicopathologic analysis of 3 cases of PET scan-positive leiomyomas and literature review. Gynecol Oncol. 2007;104(1):247-52. Chura JC, Van Iseghem K, Downs LS Jr, Carson LF, Judson PL. Bevacizumab plus cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer. Gynecol Oncol. 2007;107(2):326-30. Chura JC, Downs LS Jr. Positron emission tomography and uterine leiomyomas: Authors' response. Gynecol Oncol. 2007; Oct 23 [Epub ahead of print] Bradley WH, Lima PH, Rodgers L, Blomquist CH, Downs LS. Endometrial carcinoma expresses an increased cathepsin B/D ratio. Gynecol Oncol. 2008;108(1):84-9. Downs LS Jr, Judson PL, Argenta PA, Ghebre R, Geller MA, Bliss RL, Boente MP, Nahhas WA, Abu-Ghazaleh SZ, Chen MD, Carson LF. A prospective randomized trial of thalidomide with topotecan compared with topotecan alone in women with recurrent epithelial ovarian carcinoma. Cancer 2008;112(2):331-9. Argenta PA, Ormsby RR, Downs LS Jr, Judson PL, Ghebre R, Carson LF. Routine pelvic examination during front-line chemotherapy for ovarian cancer: should it play a role? J Reprod Med. 2008 Jan; 53(1): 3-7. Downs LS, Smith JS, Scarinci I, Flowers L, Parham G. The disparity of cervical cancer in diverse populations. Gynecol Oncol. 2008 May; 109(2 Suppl): S22-30. Review. Herzog TJ, Huh WK, Downs LS, Smith JS, Monk BJ. Initial lessons learned in HPV vaccination. Gynecol Oncol. 2008 May; 109(2Suppl): S4-11. Review. Jonson AL, Rogers LM, Ramakrishnan S, Downs LS Jr. Gene silencing with siRNA targeting E6/E7 as a therapeutic intervention in a mouse model of cervical cancer. Gynecol Oncol. 2008 Nov; 111(2): 356-64. Epub 2008 Aug 27. Ogilvie JW Jr, Park IU, Downs LS, Anderson KE, Hansberger J, Madoff RD. Anal dysplasia in kidney transplant recipients. J Am Coll Surg. 2008 Dec; 207(6): 914-21. Epub 2008 Sep 30. Argenta PA, Thomas SG, Judson PL, Downs LS Jr, Geller MA, Carson LF, Jonson AL, Ghebre R. A phase II study of fulvestrant in the treatment of multiply-recurrent epithelial ovarian cancer. Gynecol Oncol. 2009 Feb 22. [Epub ahead of print] Ralston Howe E, Li Z, McGlennen RC, Hellerstedt WL, Downs LS Jr. Type-specific prevalence and persistence of human papillomavirus in women in the United States who are referred for typing as a component of cervical cancer screening. Am J Obstet Gynecol. 2009 Mar; 200(3): 245.e1-7. Clinics:
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