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Contact Information

Phone:  
Office: (612) 624-8267
Lab: (612) 626-7640
Fax: (612) 626-7640

Email: ferri013@umn.edu

Address:
Department of Ophthalmology & Neurosciences
380 Lions Research Building
2001 6th Street SE
Minneapolis, MN 55455

Research

• Immunoproteasome and cellular stress response
• Proteasome function in the aging retina
• Age-related macular degeneration

Education and Training

Graduate School: University of Kansas
Post-doc: University of Kansas

Honors and Awards

Invited Speaker, International Society of Eye Research, Montreal, Canada, 2010

Keynote Speaker, Midwest Eye Research Symposium, Iowa City, IA, 2010

Invited Speaker, Oxidative Stress and Disease Gordon Research Conference, Il Ciocco, Italy, 2009

Invited Speaker, International Society of Eye Research, Beijing, China, 2008

Invited Speaker, Biology of Aging Gordon Research Conference, Les Diables, Switzerland, 2007

Invited Symposium Speaker, Association for Research in Vision and Ophthalmology International Conference, Ft. Lauderdale, Florida, 2006-07

Fesler-Lampert Chair in Aging Research, Center on Aging, University of Minnesota, 2003-04

Published Works

Published Articles for research on AMD:
Karunadharma PP, Nordgaard CL, Olsen TW, Ferrington DA. (2010) Mitochondrial DNA damage as a potential mechanism for Age-related macular degeneration. Invest. Ophthalmol. Vis. Sci., in press.

Nordgaard CL, Karunadharma PP, Feng X, Olsen TW, Ferrington DA. (2008) Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 49: 2848-55.

Ethen CM, Hussong SA, Reilly C, Feng X, Olsen TW, Ferrington DA. (2007) Transformation of the proteasome with age-related macular degeneration. FEBS Lett. 581: 885-90.

Nordgaard, C.L., Berg, K.M, Kapphahn, R.J., Reilly, C., Feng, X., Olsen, T.W., Ferrington, D.A., (2006) Proteomics of the Retinal Pigment Epithelium Reveals Altered Protein Expression at Progressive Stages of Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 47: 815-22.

Ethen CM, Reilly C, Feng X, Olsen TW, Ferrington DA. (2006) The proteome of central and peripheral retina with progression of age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 47: 2280-90.

Published Articles on Proteasome research:
Hussong SA, Kapphahn RJ, Phillips SL, Maldonado M, Ferrington DA., (2010) Immunoproteasome deficiency alters retinal proteasome’s response to stress. J Neurochem 113: 1481-90.

Balog, E.M., Lockamy, E.L., Thomas, D.D., Ferrington, D.A., (2009) Site-specific methionine oxidation initiates calmodulin degradation by the 20S proteasome. Biochemistry, 48: 3005-16.

Ferrington, D.A., Hussong, S.A., Roehrich, H., Kapphahn, R.J., Kavanaugh, S.M., Heuss, N.D., Gregerson, D.S., (2008) Immunoproteasome Responds to Injury in the Retina and Brain. J Neurochem, 106:158-69.

Kapphahn, R.J., Bigelow, E.J., and Ferrington, D.A., (2007) Age-dependent Inhibition of Proteasome Chymotrypsin-like Activity in the Retina. Exp. Eye Res., 84(4): 646-54.

Louie, J.L., Kapphahn, R.J. and Ferrington, D.A., (2002) Proteasome Function and Protein Oxidation in the Aged Retina. Exp. Eye Res. 75: 271-84.