Dale S. Gregerson, Ph.D. - MED - Ophthalmology Department, University of Minnesota

Contact Information

Phone: (612) 626-0772 office
(612) 626-0773 lab
Fax: (612) 626-0781

Email: grege001@umn.edu

Address:
Department of Ophthalmology
314 Lions Research Building
2001 6th Street SE
Minneapolis, MN 55455

Research

Immunonology and the eye
Retinal antigens
Immunity in neurodegeneration/neuroprotection

Education and Training

Graduate School: University of British Columbia
Post-doc: Yale University

Honors and Awards

Medical Research Council of Canada Predoctoral Traineeship, 1972-76

NIH Post-Doctoral Traineeship, 1976-1978

'James S. Adams Research Scholar Award', Research to Prevent Blindness, 1983

'Senior Scientific Investigator Award', Research to Prevent Blindness, 1989

ARVO Silver Fellow, 2008

Published Works

105. McPherson, S.W., Heuss, N.D., Lehman, U. and Gregerson, D.S. Generation of regulatory T cells to antigen expressed in the retina. Curr. Immunol Rev. In Press.

104. Tewalt, E.F., Grant, J.M., Granger, E.L., Palmer, D.C., Heuss, N.D., Gregerson, D.S., Restifo, N.P., and Norbury, C.C. Viral sequestration of antigen subverts cross presentation to CD8+ T cells. PLoS Pathog 5(5): e1000457, 2009.

103. Gregerson, D.S., Heuss, N.D., Lehmann, U., and McPherson, S.W. Peripheral tolerance induction by retinal antigen expression. J. Immunol. 183:814-822, 2009.

102. McPherson, S.W., Heuss, N.D., and Gregerson, D.S. Lymphopenia-induced proliferation is a potent activator for CD4 T cell mediated autoimmune disease in the retina. J. Immunol. 182:969-979, 2009.

101. Ferrington, D.A., Hussong, S.A., Roehrich, H., Kapphahn, R.J., Kavanaugh, S.M., Heuss, N.D., and Gregerson, D.S. Immunoproteasome responds to injury in the retina and brain. J. Neurochem. 106:156-69, 2008.

100. Gregerson, D.S., Heuss, N.D., Lehmann, U., and McPherson, S.W. Evidence for extra-thymic generation of regulatory T cells specific for a retinal antigen. Ophthalmic Res. 40:154-159, 2008.

99. Gregerson, D.S., Use of a ß-galactosidase reporter coupled to cell-specific promoters to examine differentiation of neural progenitor cells in vivo and in vitro. In: Stem Cells and Regenerative Medicine. Editors; Low, W.C, and Verfaillie, C.M. World Scientific, Hackensack, N.J.: 2008.

98. Gregerson DS, Heuss ND, Lew KL, McPherson SW, Ferrington DA. Interaction of retinal pigmented epithelial cells and CD4 T cells leads to T-cell anergy. Invest Ophthalmol Vis Sci. 48:4654-4663, 2007.

97. Gregerson, D.S., Lew, K.L., McPherson, S.W., Heuss, N.D., and Ferrington, D.A. RPE resist bystander killing by CTLs, but are highly susceptible to antigen-dependent CTL killing. Invest. Ophthalmol. Vis. Sci. 47:5385-5394, 2006.

96. Ferrington, D.A., Tran, T.N., Lew, K.L., Van Remmen, H. and Gregerson, D.S. Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells. Exp Eye Res. 83:638-650, 2006.

95. Sam, T.N., Xiao, J., Roehrich, H., Low, W.C. and Gregerson, D.S. Engrafted neural progenitor cells express a tissue-restricted reporter gene associated with differentiated retinal photoreceptor cells. Cell Transplant. 15:147-60, 2006.